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S100 Proteins

  • Reference work entry
Encyclopedia of Signaling Molecules

  • 226 Accesses

Synonyms

S100 calcium-binding protein

S100 Protein Family Members

S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, S100A7, S100A8, S100A9, S100A10, S100A11, S100A12, S100A13, S100A14, S100A15, S100A16, S100B, S100P, S100G, S100Z, trichohylin, filaggrin, filaggrin-2, cornulin, repetin

Historical Background/General: S100 Family

S100 proteins were first discovered in 1965 by Moore as a major protein fraction (0.6% of total soluble protein) isolated from bovine brain (Moore 1965). The protein was given the name S100 due to its high solubility in saturated ammonium sulfate. Later experiments showed the S100 protein fraction constituted two different dimeric species comprised of two β protomers (S100B) or an α, β heterodimer (Isobe et al. 1977). Early members of the S100 protein family were frequently given suffixes based on their localization or molecular size and included S100P (placental), S100C (cardiac or calgizzarin), p11 (11 kDa), and MRP8/MRP14 (myeloid regulatory proteins, 8 and...

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References

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Authors and Affiliations

  1. Department of Biochemistry, The University of Western Ontario, London, ON, N6A5C1, Canada

    Dr. Brian R. Dempsey, Dr. Anne C. Rintala-Dempsey & Prof. Gary S. Shaw

Authors
  1. Dr. Brian R. Dempsey
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  2. Dr. Anne C. Rintala-Dempsey
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  3. Prof. Gary S. Shaw
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Corresponding author

Correspondence to Gary S. Shaw .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Dempsey, B.R., Rintala-Dempsey, A.C., Shaw, G.S. (2012). S100 Proteins. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_426

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