Phosphatidylinositol 5-phosphate 4-kinase
Reference work entry
Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) is an enzyme activity capable of converting a mono-phosphorylated lipid substrate into a bis-phosphorylated product, a reaction that is fundamental in the maintenance of the cellular phosphoinositide (PI) cycle. PIP4K catalyzes the addition of a phosphate group to position D-4 of the inositol head-group of PtdIns5 P (Figs. 1 and 2). Downstream effects of signaling molecules generated by the PI cycle are diverse and include vesicle trafficking, ion channel activity, cytoskeletal dynamics, cell differentiation, proliferation, and apoptosis (Toker 2002; Irvine 2003; Di Paolo and De Camilli 2006; Gonzales and Anderson 2006).
- McCrea HJ, De Camilli P. Mutations in phosphoinositide metabolizing enzymes and human disease. Physiology (Bethesda). 2009;24:8–16.Google Scholar
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