Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

Regulator of Calcineurin 1 (RCAN1)

  • Masakazu Fujiwara
  • Mohammad Ghazizadeh
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_389

Synonyms

Historical Background

Regulator of calcineurin 1 (RCAN1) was first isolated by Fuentes et al. in 1995 during a search for genes associated with clinical features of Down syndrome (e.g., mental retardation and congenital heart disease) (Fuentes et al. 1995). Coding sequences of RCAN1 were identified from the 21q22.1–q22.2 region of human chromosome 21 by an Alu-splice PCR method. It was initially thought that RCAN1 was significantly associated with the Down syndrome phenotype (Fuentes et al. 1997b), thus RCAN1 was first designated Down Syndrome Critical Region 1 (DSCR1). Future studies showed that the DSCR1 gene product is a calcineurin regulator, and the new name “regulator of calcineurin (RCAN)” was adopted to describe the gene function. Although RCAN1 is still referred to as DSCR1, ADAPT78, MCIP1, Calcipressin1, RCN-1,...

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References

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Molecular PathologyInstitute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical SchoolKawasakiJapan