Skip to main content

Tead

  • Reference work entry
  • 102 Accesses

Synonyms

[TEAD1] AbaA (Aspergillus nidulans); Gtrgeo5; M-CAT binding factor; mTEF-1; Scalloped (Sd) (D. Melanogaster); Tcf13; TEA domain family member 1; TEAD-1; TEAD1; TEC1 (S. cerevisiae); TEF-1; TEF1

[TEAD2] Etdf; ETF; TEA domain family member 2; TEAD-2; TEAD2; TEF-4; TEF4

[TEAD3] DTEF-1; ETFR-1; Tcf13r2; TEA domain family member 3; TEAD-3; TEAD3; TEF-5

[TEAD4] Rtef-1; Tcf13r1; TEA domain family member 4; TEAD-4; TEAD4; Tef-3; Tefr1a; Tefr1b

Historical Background

In vertebrates, the TEAD family of transcription factors is comprised of four members that contain a highly conserved (99–100%) DNA-binding domain, designated the TEA/ATTS domain (Burglin 1991) (Fig. 1). This highly conserved domain is comprised of three α helical domains and is not confined to vertebrates, but is also found in transcription factors from multiple organisms, including the TEAD1 homologs AbaA (Aspergillus nidulans), TEC1 (Saccharomyces cerevisiae), and scalloped (sd, Drosophila melanogaster). Thus TEAD...

This is a preview of subscription content, log in via an institution.

References

  • Burglin TR. The TEA domain: a novel, highly conserved DNA-binding motif. Cell. 1991;66:11–2.

    PubMed  CAS  Google Scholar 

  • Chen Z, Friedrich GA, Soriano P. Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev. 1994;8:2293–301.

    PubMed  CAS  Google Scholar 

  • Chen L, Chan SW, Zhang X, Walsh M, Lim CJ, Hong W, Song H. Structural basis of YAP recognition by TEAD4 in the hippo pathway. Genes Dev. 2010;24:290–300.

    PubMed  Google Scholar 

  • Eberhardt NL, Jiang SW, Shepard AR, Arnold AM, Trujillo MA. Hormonal and cell-specific regulation of the human growth hormone and chorionic somatomammotropin genes. Prog Nucleic Acid Res Mol Biol. 1996;54:127–63.

    PubMed  CAS  Google Scholar 

  • Jacquemin P, Davidson I. The role of the TEF transcription factors in cardiogenesis and other developmental processes. Trends Cardiovasc Med. 1997;7:192–7.

    PubMed  CAS  Google Scholar 

  • Kaneko KJ, DePamphilis ML. Regulation of gene expression at the beginning of mammalian development and the TEAD family of transcription factors. Dev Genet. 1998;22:43–55.

    PubMed  CAS  Google Scholar 

  • Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, Sasaki H. Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol. 2008;28:3177–89.

    PubMed  CAS  Google Scholar 

  • Walker WH, Fitzpatrick SL, Barrera-Saldana HA, Resendez-Perez D, Saunders GF. The human placental lactogen genes: structure, function, evolution and transcriptional regulation. Endocr Rev. 1991;12:316–28.

    PubMed  CAS  Google Scholar 

  • Xiao JH, Davidson I, Matthes H, Garnier JM, Chambon P. Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1. Cell. 1991;65:551–68.

    PubMed  CAS  Google Scholar 

  • Yagi R, Kohn MJ, Karavanova I, Kaneko KJ, Vullhorst D, DePamphilis ML, Buonanno A. Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development. Development. 2007;134:3827–36.

    PubMed  CAS  Google Scholar 

  • Yoshida T. MCAT elements and the TEF-1 family of transcription factors in muscle development and disease. Arterioscler Thromb Vasc Biol. 2008;28:8–17.

    PubMed  CAS  Google Scholar 

  • Zhao B, Lei QY, Guan KL. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr Opin Cell Biol. 2008;20:638–46.

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

I wish to extend my apologies to the many authors whose contributions could not be cited due to space limitations. Where possible I have cited review articles to allow readers access to the literature. In addition, the readers may access additional information and references on TEAD via the Nature-UCSD signaling gateway: http://www.signaling-gateway.org/.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Norman L. Eberhardt .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media, LLC

About this entry

Cite this entry

Eberhardt, N.L. (2012). Tead. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_357

Download citation

Publish with us

Policies and ethics