Skip to main content
SpringerLink
Log in

Polycystin-2

  • Reference work entry
Book cover Encyclopedia of Signaling Molecules

  • 79 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • AbouAlaiwi WA, Takahashi M, Mell BR, Jones TJ, Ratnam S, Kolb RJ, et al. Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades. Circ Res. 2009;104(7):860–869.

    PubMed  CAS  Google Scholar 

  • Anyatonwu GI, Estrada M, Tian X, Somlo S, Ehrlich BE. Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc Natl Acad Sci USA. 2007;104(15):6454–6459.

    PubMed  CAS  Google Scholar 

  • Barr MM, Sternberg PW. A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. Nature. 1999;401(6751):386–389.

    PubMed  CAS  Google Scholar 

  • Gao H, Wang Y, Wegierski T, Skouloudaki K, Putz M, Fu X, et al. PRKCSH/80 K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation. Hum Mol Genet. 2010;19(1):16–24.

    PubMed  CAS  Google Scholar 

  • Geng L, Okuhara D, Yu Z, Tian X, Cai Y, Shibazaki S, et al. Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif. J Cell Sci. 2006;119(Pt 7):1383–1395.

    PubMed  CAS  Google Scholar 

  • Kimberling WJ, Kumar S, Gabow PA, Kenyon JB, Connolly CJ, Somlo S. Autosomal dominant polycystic kidney disease: localization of the second gene to chromosome 4q13-q23. Genomics. 1993;18(3):467–472.

    PubMed  CAS  Google Scholar 

  • Kaja S, Hilgenberg JD, Rybalchenko V, Medina-Ortiz WE, Gregg EV, Koulen P. Polycystin-2 expression and function in adult mouse lacrimal acinar cells. Invest Ophthalmol Vis Sci. 2011;52(8):5605–5611.

    PubMed  CAS  Google Scholar 

  • Koulen P, Cai Y, Geng L, Maeda Y, Nishimura S, Witzgall R, Ehrlich BE, Somlo S. Polycystin-2 is an intracellular calcium release channel. Nat Cell Biol. 2002;4(3):191–197.

    PubMed  CAS  Google Scholar 

  • Koulen P, Duncan RS, Liu J, Cohen NE, Yannazzo JA, McClung N, Lockhart CL, Branden M, Buechner M. Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans. Cell Calcium. 2005;37(6):593–601 Epub 2005 Apr 14.

    PubMed  CAS  Google Scholar 

  • Koulen P, McClung NM. Polycystin 2. [Web Page]: Nature Molecule Pages; 2006 [cited 2006 May].

    Google Scholar 

  • Li X, Luo Y, Starremans PG, McNamara CA, Pei Y, Zhou J. Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol. 2005;7(12):1202–1212.

    PubMed  Google Scholar 

  • Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, et al. A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. J Biol Chem. 2009;284(49):34400–34412.

    PubMed  CAS  Google Scholar 

  • Montalbetti N, Li Q, Wu Y, Chen XZ, Cantiello HF. Polycystin-2 cation channel function in the human syncytiotrophoblast is regulated by microtubular structures. J Physiol. 2007;579(Pt 3):717–728.

    PubMed  CAS  Google Scholar 

  • Peters DJM, Spruit L, Saris JJ, Ravine D, Sandkuijl LA, Fossdal R, et al. Chromosome 4 localization of a second gene for autosomal dominant polycystic kidney disease. Nat Genet. 1993;5(4):359–362.

    PubMed  CAS  Google Scholar 

  • Petri ET, Celic A, Kennedy SD, Ehrlich BE, Boggon TJ, Hodsdon ME. Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+−dependent regulation of polycystin-2 channel activity. Proc Natl Acad Sci USA. 2010;107(20):9176–9181.

    PubMed  CAS  Google Scholar 

  • Sammels E, Devogelaere B, Mekahli D, Bultynck G, Missiaen L, Parys JB, et al. Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain. J Biol Chem. 2010;285(24):18794–18805.

    PubMed  CAS  Google Scholar 

  • Sharif-Naeini R, Folgering JH, Bichet D, Duprat F, Lauritzen I, Arhatte M, et al. Polycystin-1 and -2 dosage regulates pressure sensing. Cell. 2009;139(3):587–596.

    PubMed  CAS  Google Scholar 

  • Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, et al. Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice. Hepatology. 2010;51(5):1778–1788.

    PubMed  CAS  Google Scholar 

  • Tsiokas L. Function and regulation of TRPP2 at the plasma membrane. Am J Physiol Ren Physiol. 2009;297(1):F1–F9.

    CAS  Google Scholar 

  • Tsiokas L, Kim S, Ong EC. Cell biology of polycystin-2. Cell Signal. 2007;19(3):444–453.

    PubMed  CAS  Google Scholar 

  • Xia S, Li X, Johnson T, Seidel C, Wallace DP, Li R. Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development. 2010;137(7):1075–1084.

    PubMed  CAS  Google Scholar 

  • Xiao ZS, Quarles LD. Role of the polycytin-primary cilia complex in bone development and mechanosensing. Ann NY Acad Sci. 2010;1192(1):410–421.

    PubMed  CAS  Google Scholar 

  • Zhou J. Polycystins and primary cilia: primers for cell cycle progression. Annu Rev Physiol. 2009;71:83–113.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology and Department of Basic Medical Science, University of Missouri - Kansas City School of Medicine, Vision Research Center, 2411 Holmes Street, Kansas City, MO, 64108, USA

    Dr. Daryl L. Goad, Dr. Michael A. Grillo & Prof. Peter Koulen

Authors
  1. Dr. Daryl L. Goad
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dr. Michael A. Grillo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Prof. Peter Koulen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Peter Koulen .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media, LLC

About this entry

Cite this entry

Goad, D.L., Grillo, M.A., Koulen, P. (2012). Polycystin-2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_345

Download citation

Publish with us

Policies and ethics

Search

Navigation