Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

Pim-1

  • Christopher T. Cottage
  • Balaji Sundararaman
  • Shabana Din
  • Nirmala Hariharan
  • Mark A. Sussman
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_344

Synonyms

Historical Background

The serine-threonine kinase Pim-1 belongs to the Calmodulin-dependent protein kinase family together with two other highly conserved family members (Pim-2 and Pim-3). Pim-1 is the preferential site of integration for the Moloney murine leukemia virus (Proviral Integration for Moloney Virus) discovered over 25 years ago (Selten et al. 1985). Pim-1 plays pivotal roles in cellular proliferation, differentiation, metabolism, and survival by phosphorylating and interacting with many targets. A literature search reveals the dynamic expression and activity of Pim-1 depends upon cell type and response to stimuli, either pathologic or homeostatic. Specifically, Pim-1 is expressed in various hematopoietic sites including thymus, spleen, bone marrow, and fetal liver, but can also be found in the heart, oral epithelia, prostate, hippocampus, vascular smooth muscle, and many tumorigenic cell types...

This is a preview of subscription content, log in to check access.

References

  1. Bachmann M, Moroy T. The serine/threonine kinase Pim-1. Int J Biochem Cell Biol. 2005;37(4):726–30.PubMedGoogle Scholar
  2. Bachmann M, Kosan C, et al. The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C. Int J Biochem Cell Biol. 2006;38(3):430–43.PubMedGoogle Scholar
  3. Bhattacharya N, Wang Z, et al. Pim-1 associates with protein complexes necessary for mitosis. Chromosoma. 2002;111(2):80–95.PubMedGoogle Scholar
  4. Borillo GA, Mason M, et al. Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res. 2010;106(7):1265–74.PubMedGoogle Scholar
  5. Chen J, Kobayashi M, et al. Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation. Am J Pathol. 2009;175(1):400–11.PubMedGoogle Scholar
  6. Cottage CT, Bailey B, et al. Cardiac progenitor cell cycling stimulated by Pim-1 kinase. Circ Res. 2010;106(5):891–901.PubMedGoogle Scholar
  7. Fischer KM, Cottage CT, et al. Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase. Circulation. 2009;120(21):2077–87.PubMedGoogle Scholar
  8. Katare R, Caporali A, et al. Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circ Res. 2011;108(10):1238–51.PubMedGoogle Scholar
  9. Krishnan N, Pan H, et al. Prolactin-regulated pim-1 transcription: identification of critical promoter elements and Akt signaling. Endocrine. 2003;20(1–2):123–30.PubMedGoogle Scholar
  10. Mochizuki T, Kitanaka C, et al. Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. J Biol Chem. 1999;274(26):18659–66.PubMedGoogle Scholar
  11. Morishita D, Katayama R, et al. Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res. 2008;68(13):5076–85.PubMedGoogle Scholar
  12. Muraski JA, Rota M, et al. Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med. 2007;13(12):1467–75.PubMedGoogle Scholar
  13. Nawijn MC, Alendar A, et al. For better or for worse: the role of Pim oncogenes in tumorigenesis. Nat Rev Cancer. 2011;11(1):23–34.PubMedGoogle Scholar
  14. Selten G, Cuypers HT, et al. Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas. EMBO J. 1985;4(7):1793–8.PubMedGoogle Scholar
  15. Shay KP, Wang Z, et al. Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway. Mol Cancer Res. 2005;3(3):170–81.PubMedGoogle Scholar
  16. Willert M, Augstein A, et al. Transcriptional regulation of Pim-1 kinase in vascular smooth muscle cells and its role for proliferation. Basic Res Cardiol. 2010;105(2):267–77.PubMedGoogle Scholar
  17. Zhang Y, Wang Z, et al. Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells. Mol Cancer Res. 2007;5(9):909–22.PubMedGoogle Scholar
  18. Zhang Y, Wang Z, et al. Pim kinase-dependent inhibition of c-Myc degradation. Oncogene. 2008;27(35):4809–19.PubMedGoogle Scholar
  19. Zhao Y, Hamza MS, et al. Kruppel-like factor 5 modulates p53-independent apoptosis through Pim1 survival kinase in cancer cells. Oncogene. 2008;27(1):1–8.PubMedGoogle Scholar
  20. Zippo A, De Robertis A, et al. PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. Nat Cell Biol. 2007;9(8):932–44.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Christopher T. Cottage
    • 1
  • Balaji Sundararaman
    • 1
  • Shabana Din
    • 1
  • Nirmala Hariharan
    • 1
  • Mark A. Sussman
    • 2
  1. 1.San Diego State Heart InstituteSan Diego State UniversitySan DiegoUSA
  2. 2.SDSU Heart InstituteSan Diego State University Biology DepartmentSan DiegoUSA