Historical Background
The G-protein-coupled receptor (GPCR), PSGR, was first identified by three distinct laboratories using different experimental approaches (Xu et al. 2000; Xia et al. 2001; Yuan et al. 2001). GPCRs constitute the largest gene family in the genome capable of influencing multiple signal transduction pathways; at the same time, they are the target of over half of the medications currently available in the pharmaceutical industry, demonstrating the importance of these receptors in maintaining tissue homeostasis. Research on this molecule has focused on its expression pattern and probable role as a potential biomarker for prostate cancer as well as in the possibility of a role in influencing prostate cancer initiation and progression, and the mechanisms through which this is done.
PSGR as a Molecule: Structural Analysis
Protein sequence analysis of PSGR predicted the presence of seven...
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References
Neuhaus EM, Zhang W, Gelis L, Deng Y, Noldus J, Hatt H. Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. J Biol Chem. 2009;284(24):16218–25.
Rigau M, Morote J, Mir MC, Ballesteros C, Ortega I, Sanchez A, et al. PSGR and PCA3 as biomarkers for the detection of prostate cancer in urine. Prostate. 2010;70(16):1760–7.
Spehr J, Gelis L, Osterloh M, Oberland S, Hatt H, Spehr M, Neuhaus EM. G-protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation. J Biol Chem. 2011;286(15):13184–92.
Wang J, Weng J, Cai Y, Penland R, Liu M, Ittmann M. The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase. Prostate. 2006;66(8):847–57.
Weng J, Wang J, Cai Y, Stafford LJ, Mitchell D, Ittmann M, Liu M. Increased expression of prostate-specific G-protein coupled receptor in human prostate intraepithelial neoplasia and prostate cancers. Int J Cancer. 2005a;113(5):811–18.
Weng J, Ma W, Mitchell D, Zhang J, Liu M. Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors. J Cell Biochem. 2005b;96(5):1034–48.
Xia C, Ma W, Wang F, Hua Shao-bing, Liu M, et al. Identification of a prostate-specific G protein coupled receptor in prostate cancer. Oncogene. 2001;20:5903–7.
Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, et al. PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. Cancer Res. 2000;60(23):6568–72.
Xu LL, Sun C, Petrovics G, Makarem M, Furusato B, Zhang W, et al. Quantitative expression profile of PSGR in prostate cancer. Prostate Cancer Prostatic Dis. 2006;9(1):56–61.
Yuan TT, Toy P, McClary JA, Lin RJ, Miyamoto NG, Kretschmer PJ. Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species. Gene. 2001;278(1–2):41–51.
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Liu, M., Rodriguez, M. (2012). PSGR. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_338
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DOI: https://doi.org/10.1007/978-1-4419-0461-4_338
Publisher Name: Springer, New York, NY
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