Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi


  • Mingyao Liu
  • Melissa Rodriguez
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_338


Historical Background

The G-protein-coupled receptor (GPCR), PSGR, was first identified by three distinct laboratories using different experimental approaches (Xu et al. 2000; Xia et al. 2001; Yuan et al. 2001). GPCRs constitute the largest gene family in the genome capable of influencing multiple signal transduction pathways; at the same time, they are the target of over half of the medications currently available in the pharmaceutical industry, demonstrating the importance of these receptors in maintaining tissue homeostasis. Research on this molecule has focused on its expression pattern and probable role as a potential biomarker for prostate cancer as well as in the possibility of a role in influencing prostate cancer initiation and progression, and the mechanisms through which this is done.

PSGR as a Molecule: Structural Analysis

Protein sequence analysis of PSGR predicted the presence of seven...

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  1. Neuhaus EM, Zhang W, Gelis L, Deng Y, Noldus J, Hatt H. Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. J Biol Chem. 2009;284(24):16218–25.PubMedGoogle Scholar
  2. Rigau M, Morote J, Mir MC, Ballesteros C, Ortega I, Sanchez A, et al. PSGR and PCA3 as biomarkers for the detection of prostate cancer in urine. Prostate. 2010;70(16):1760–7.PubMedGoogle Scholar
  3. Spehr J, Gelis L, Osterloh M, Oberland S, Hatt H, Spehr M, Neuhaus EM. G-protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation. J Biol Chem. 2011;286(15):13184–92.PubMedGoogle Scholar
  4. Wang J, Weng J, Cai Y, Penland R, Liu M, Ittmann M. The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase. Prostate. 2006;66(8):847–57.PubMedGoogle Scholar
  5. Weng J, Wang J, Cai Y, Stafford LJ, Mitchell D, Ittmann M, Liu M. Increased expression of prostate-specific G-protein coupled receptor in human prostate intraepithelial neoplasia and prostate cancers. Int J Cancer. 2005a;113(5):811–18.PubMedGoogle Scholar
  6. Weng J, Ma W, Mitchell D, Zhang J, Liu M. Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors. J Cell Biochem. 2005b;96(5):1034–48.PubMedGoogle Scholar
  7. Xia C, Ma W, Wang F, Hua Shao-bing, Liu M, et al. Identification of a prostate-specific G protein coupled receptor in prostate cancer. Oncogene. 2001;20:5903–7.PubMedGoogle Scholar
  8. Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, et al. PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. Cancer Res. 2000;60(23):6568–72.PubMedGoogle Scholar
  9. Xu LL, Sun C, Petrovics G, Makarem M, Furusato B, Zhang W, et al. Quantitative expression profile of PSGR in prostate cancer. Prostate Cancer Prostatic Dis. 2006;9(1):56–61.PubMedGoogle Scholar
  10. Yuan TT, Toy P, McClary JA, Lin RJ, Miyamoto NG, Kretschmer PJ. Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species. Gene. 2001;278(1–2):41–51.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Molecular and Cellular Medicine, Institute of Biosciences and TechnologyTexas A&M University Health Science CenterHoustonUSA
  2. 2.Center for Cancer and Stem Cell BiologyInstitute of Biosciences and Technology, Texas A&M Health Science CenterHoustonUSA