The G-protein-coupled receptor (GPCR), PSGR, was first identified by three distinct laboratories using different experimental approaches (Xu et al. 2000; Xia et al. 2001; Yuan et al. 2001). GPCRs constitute the largest gene family in the genome capable of influencing multiple signal transduction pathways; at the same time, they are the target of over half of the medications currently available in the pharmaceutical industry, demonstrating the importance of these receptors in maintaining tissue homeostasis. Research on this molecule has focused on its expression pattern and probable role as a potential biomarker for prostate cancer as well as in the possibility of a role in influencing prostate cancer initiation and progression, and the mechanisms through which this is done.
PSGR as a Molecule: Structural Analysis
Protein sequence analysis of PSGR predicted the presence of seven...