Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

PSGR

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_338

Synonyms

Historical Background

The G-protein-coupled receptor (GPCR), PSGR, was first identified by three distinct laboratories using different experimental approaches (Xu et al. 2000; Xia et al. 2001; Yuan et al. 2001). GPCRs constitute the largest gene family in the genome capable of influencing multiple signal transduction pathways; at the same time, they are the target of over half of the medications currently available in the pharmaceutical industry, demonstrating the importance of these receptors in maintaining tissue homeostasis. Research on this molecule has focused on its expression pattern and probable role as a potential biomarker for prostate cancer as well as in the possibility of a role in influencing prostate cancer initiation and progression, and the mechanisms through which this is done.

PSGR as a Molecule: Structural Analysis

Protein sequence analysis of PSGR predicted the presence of seven...

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References

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Molecular and Cellular Medicine, Institute of Biosciences and TechnologyTexas A&M University Health Science CenterHoustonUSA
  2. 2.Center for Cancer and Stem Cell BiologyInstitute of Biosciences and Technology, Texas A&M Health Science CenterHoustonUSA