Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

ROCK Kinases

  • Michael S. Samuel
  • Michael F. Olson
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_328


Historical Background

The small molecular weight GTP-binding proteins of the Rho family, which comprises 22 proteins including RhoA, Rac1, and Cdc42, were originally isolated based on their high degree of homology with the Ras proto-oncogenes (Rho = Ras homologue). Following their identification, a variety of approaches were used to isolate interacting proteins that might convey signals downstream to regulate numerous biological processes. One approach was to use GTP-loaded RhoA as a high-affinity reagent to fish for interacting proteins, and the ROCK kinases were identified in this way (Leung et al. 1995; Ishizaki et al. 1996; Matsui et al. 1996). A number of different names have been used to describe the two kinases and early reports were sometimes not careful in accurately describing which...
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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Centre for Cancer BiologySA PathologyAdelaideAustralia
  2. 2.Molecular Cell Biology LaboratoryBeatson Institute for Cancer ResearchGlasgowUK