Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi


Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_309


Gene Location

Mouse chromosome: 6; Location: 6 60.22 cM

Human chromosome: 12; Location: p12p13

Historical Background

The Src homology region 2 (SH) domain-containing protein tyrosine phosphatase-1 (SHP-1) is a member of the large family of protein tyrosine phosphatase (PTP). SHP-1 was identified in hematopoietic cells and organs involved in immune responses such as the spleen, thymus, lymph node, and bone marrow. SHP-1 is also known as hematopoietic cell phosphatase (HCP) because of its expression in these cells. Herein the nomenclature SHP-1 will be used. Back to the beginning of the 1990s, the study of tyrosine kinases was very well advanced; however, knowledge about their natural counterpart, the tyrosine phosphatases,...

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Microbiology and Immunology, The Research Institute of The McGill University Health CentreMcGill UniversityMontréalCanada
  2. 2.Departments of Medicine and of Microbiology and Immunology, The Research Institute of The McGill University Health CentreMcGill UniversityMontréalCanada