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PTPN6

  • Reference work entry
Encyclopedia of Signaling Molecules

  • 132 Accesses

Synonyms

Hematopoietic cells phosphatase (HCP); Protein tyrosine phosphatase 1 C (PTP1C); Protein tyrosine phosphatase, non-receptor type 6 (PTPN6); Src homology region 2 (SH2)-domain phosphatase or Src homology region 2 domain-containing PTP-1 (SHP-1 or SH-PTP1)

Gene Location

Mouse chromosome: 6; Location: 6 60.22 cM

Human chromosome: 12; Location: p12p13

Historical Background

The Src homology region 2 (SH) domain-containing protein tyrosine phosphatase-1 (SHP-1) is a member of the large family of protein tyrosine phosphatase (PTP). SHP-1 was identified in hematopoietic cells and organs involved in immune responses such as the spleen, thymus, lymph node, and bone marrow. SHP-1 is also known as hematopoietic cell phosphatase (HCP) because of its expression in these cells. Herein the nomenclature SHP-1 will be used. Back to the beginning of the 1990s, the study of tyrosine kinases was very well advanced; however, knowledge about their natural counterpart, the tyrosine phosphatases, was...

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References

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Authors and Affiliations

  1. Department of Microbiology and Immunology, The Research Institute of The McGill University Health Centre, McGill University, 3775 University Street, Duff Medical Building, Room 600, H3A 2B4, Montréal, Québec, Canada

    Dr. Marina Tiemi Shio

  2. Departments of Medicine and of Microbiology and Immunology, The Research Institute of The McGill University Health Centre, McGill University, 3775 University Street, Duff Medical Building, Room 610, H3A 2B4, Montréal, Québec, Canada

    Prof. Martin Olivier

Authors
  1. Dr. Marina Tiemi Shio
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  2. Prof. Martin Olivier
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Corresponding author

Correspondence to Martin Olivier .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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© 2012 Springer Science+Business Media, LLC

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Shio, M.T., Olivier, M. (2012). PTPN6. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_309

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