Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

PTPN6

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_309

Synonyms

Gene Location

Mouse chromosome: 6; Location: 6 60.22 cM

Human chromosome: 12; Location: p12p13

Historical Background

The Src homology region 2 (SH) domain-containing protein tyrosine phosphatase-1 (SHP-1) is a member of the large family of protein tyrosine phosphatase (PTP). SHP-1 was identified in hematopoietic cells and organs involved in immune responses such as the spleen, thymus, lymph node, and bone marrow. SHP-1 is also known as hematopoietic cell phosphatase (HCP) because of its expression in these cells. Herein the nomenclature SHP-1 will be used. Back to the beginning of the 1990s, the study of tyrosine kinases was very well advanced; however, knowledge about their natural counterpart, the tyrosine phosphatases,...

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References

  1. Abu-Dayyeh I, Shio MT, Sato S, Akira S, Cousineau B, Olivier M. Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif. PLoS Negl Trop Dis. 2008;2:e305.PubMedGoogle Scholar
  2. Caron D, Savard PE, Doillon CJ, Olivier M, Shink E, Lussier JG, et al. Protein tyrosine phosphatase inhibition induces anti-tumor activity: evidence of Cdk2/p27 kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cells. Cancer Lett. 2008;262:265–75.PubMedGoogle Scholar
  3. Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournes B, et al. The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis. Nat Med. 2006;12:549–56.PubMedGoogle Scholar
  4. Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, Clermont A, Leitges M, Marette A, et al. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med. 2009;15:1298–306.PubMedGoogle Scholar
  5. Gomez MA, Alisaraie L, Shio MT, Berghuis AM, Lebrun C, Gautier-Luneau I, et al. Protein tyrosine phosphatases are regulated by mononuclear iron dicitrate. J Biol Chem. 2010;285:24620–8.PubMedGoogle Scholar
  6. Green MC, Shultz LD. Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology. J Hered. 1975;66:250–8.PubMedGoogle Scholar
  7. Lorenz U. SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels. Immunol Rev. 2009;228:342–59.PubMedGoogle Scholar
  8. Mansfield JM, Olivier M. Immune evasion by parasites. In: Kaufmann SHE, Rouse BT, Sacks DL, editors. Immunology of Infectious Disease. Washington, DC: ASM Press; 2001. p. 453–70.Google Scholar
  9. Nandan D, Knutson KL, Lo R, Reiner NE. Exploitation of host cell signaling machinery: activation of macrophage phosphotyrosine phosphatases as a novel mechanism of molecular microbial pathogenesis. J Leukoc Biol. 2000;67:464–70.PubMedGoogle Scholar
  10. Nitschke L. CD22 and Siglec-G: B-cell inhibitory receptors with distinct functions. Immunol Rev. 2009;230:128–43.PubMedGoogle Scholar
  11. Pao LI, Badour K, Siminovitch KA, Neel BG. Nonreceptor protein-tyrosine phosphatases in immune cell signaling. Annu Rev Immunol. 2007;25:473–523.PubMedGoogle Scholar
  12. Poole AW, Jones ML. A SHPing tale: perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail. Cell Signal. 2005;17:1323–32.PubMedGoogle Scholar
  13. Rojas M, Olivier M, Garcia LF. Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis. Cell Immunol. 2002;217:58–66.PubMedGoogle Scholar
  14. Shultz LD, Schweitzer PA, Rajan TV, Yi T, Ihle JN, Matthews RJ, et al. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell. 1993;73:1445–54.PubMedGoogle Scholar
  15. Tsui HW, Siminovitch KA, de Souza L, Tsui FW. Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet. 1993;4:124–9.PubMedGoogle Scholar
  16. Tsui FW, Martin A, Wang J, Tsui HW. Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1. Immunol Res. 2006;35:127–36.PubMedGoogle Scholar
  17. Wu C, Sun M, Liu L, Zhou GW. The function of the protein tyrosine phosphatase SHP-1 in cancer. Gene. 2003;306:1–12.PubMedGoogle Scholar
  18. Zhang Z, Shen K, Lu W, Cole PA. The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation. J Biol Chem. 2003;278:4668–74.PubMedGoogle Scholar
  19. Zhang L, Oh SY, Wu X, Oh MH, Wu F, Schroeder JT, et al. SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lung. J Immunol. 2010;184:1180–90.PubMedGoogle Scholar
  20. Zhu Z, Oh SY, Cho YS, Zhang L, Kim YK, Zheng T. Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation. Immunol Res. 2010;47:3–13.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Microbiology and Immunology, The Research Institute of The McGill University Health CentreMcGill UniversityMontréalCanada
  2. 2.Departments of Medicine and of Microbiology and Immunology, The Research Institute of The McGill University Health CentreMcGill UniversityMontréalCanada