Protein Tyrosine Kinase-6 (PTK6)
The intracellular protein tyrosine kinase, PTK6 (also known as the breast tumor kinase, Brk), has been implicated in the development and progression of a number of different tumor types. First identified in three separate studies in the early 1990s, it was initially found in a study to determine which tyrosine kinases were expressed in human melanocytes and then the full-length sequence was subsequently cloned from metastatic breast cancer using a screen to identify novel kinases that were expressed in tumors, but not normal breast tissue. Identification of the murine orthologue, Sik, in mouse intestinal cells was achieved by the generation of a library of kinase catalytic domains.
PTK6 is related to the Src family of protein kinases and belongs to a distinct class of enzymes which includes Frk and SRMS (reviewed in Brauer and Tyner 2010). Under normal physiological conditions, PTK6 expression is highly controlled and is...
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