Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi


  • Irene Aligianis
  • Mark Handley
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_298


Historical Background

Interest in the RAB proteins stems from early work on yeast that identified essential roles for the RABs Ypt1p (Rab1) and Sec4p in pre- and post-Golgi membrane trafficking (Salminen and Novick 1987; Segev et al. 1988). These findings prompted efforts to clone other members of the RAB gene family and it was quickly established that this family had undergone significant expansion in mammals. As each new RAB was discovered, it also became clear that different RAB proteins could adopt specific subcellular localizations, associating with particular membrane compartments and regulating the functions of these organelles. RAB18 was partially cloned in 1992, and then fully cloned in 1993 (Chavrier et al. 1992; Yu et al. 1993). Initial characterization showed that it was widely expressed in different tissues and localized to endosomes in polarized epithelia (Lutcke et...

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.MRC Human Genetics UnitWestern General HospitalEdinburghUK