Synonyms
List of Discussed GEFs
RapGEF1: C3G
RapGEF2: PDZ-GEF1, RA-GEF, CnRasGEF, KIAA0313, nRapGEP
RapGEF3: Epac, cAMP-GEF I
RapGEF4: Epac2, cAMP-GEF II
RapGEF5: MR-GEF, Repac, GFR, KIAA0277
RapGEF6: PDZ-GEF2, RA-GEF2
RasGRP2: CalDAG-GEF I
RasGRP3: GRP3, CalDAG-GEF III, KIAA0846
NSP2: BCAR3 (human), AND34 (mouse)
NSP3: Chat, SHEP
SmgGDS: RAP1GDS1
Historical Background
GTP binding proteins are extensively used in nature to regulate biological processes. Most of these proteins act as molecular switches that transition between inactive GDP-bound and active GTP-bound conformations. The largest family of GDP/GTP switches is the Ras superfamily of small-molecular-weight GTP binding proteins that constitute approximately 150 members in mammalian cells. This superfamily can be subdivided into Ras, Rho, Rab, Ran, and ARF families that regulate a myriad of cellular functions (Takai et al. 2001). True Ras proteins play major roles in coupling cell surface...
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Nguyen, H.B., Quilliam, L.A. (2012). Rap GEF Family. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_274
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