Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

Rap GEF Family

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_274


List of Discussed GEFs

  • RapGEF1: C3G

  • RapGEF2: PDZ-GEF1, RA-GEF, CnRasGEF, KIAA0313, nRapGEP

  • RapGEF3: Epac, cAMP-GEF I

  • RapGEF4: Epac2, cAMP-GEF II

  • RapGEF5: MR-GEF, Repac, GFR, KIAA0277

  • RapGEF6: PDZ-GEF2, RA-GEF2

  • RasGRP2: CalDAG-GEF I

  • RasGRP3: GRP3, CalDAG-GEF III, KIAA0846

  • NSP2: BCAR3 (human), AND34 (mouse)

  • NSP3: Chat, SHEP

  • SmgGDS: RAP1GDS1

Historical Background

GTP binding proteins are extensively used in nature to regulate biological processes. Most of these proteins act as molecular switches that transition between inactive GDP-bound and active GTP-bound conformations. The largest family of GDP/GTP switches is the Ras superfamily of small-molecular-weight GTP binding proteins that constitute approximately 150 members in mammalian cells. This superfamily can be subdivided into Ras, Rho, Rab,  Ran, and ARF families that regulate a myriad of cellular functions (Takai et al. 2001). True Ras proteins play major roles in coupling cell surface...

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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyIndiana University School of MedicineIndianapolisUSA