Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

RIN Family Proteins (RIN1, RIN2, and RIN3)

  • John Colicelli
  • Pamela Y. Ting
  • Christine Janson
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_217


Historical Background

The RIN1 and RIN2 genes were first identified in a selection for expressed human cDNAs that suppress phenotypes associated with oncogenic RAS mutations in a yeast model system (Colicelli et al. 1991). Subsequent analysis demonstrated that RIN1 binds specifically to activated (GTP-bound) human HRAS (Han and Colicelli 1995; Han et al. 1997), suggesting that RIN1 is a downstream effector of RAS family proteins. RIN2 and RIN3 also bind to activated HRAS (Rodriguez-Viciana et al. 2004). All three RIN proteins contain a carboxy terminal RAS association (RA) domain that mediates this interaction (Colicelli (2004)).

It was subsequently reported that RIN1 encodes a VPS9-related guanine nucleotide exchange factor (GEF) function specific for the RAB5 family of early endocytosis GTPase (Tall et al. 2001). RIN2 and RIN3 also encode VPS9-type GEF domains upstream of the RA domain. This suggests that RIN family proteins are RAS effectors...

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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • John Colicelli
    • 1
  • Pamela Y. Ting
    • 1
  • Christine Janson
    • 1
  1. 1.Department of Biological ChemistryDavid Geffen School of Medicine at UCLALos AngelesUSA