Nucleoside triphosphate diphosphohydrolases (NTPDases), originally ATP diphosphohydrolases (ATPDases) with the common name apyrase, are by definition enzymes which split the γ- and β-phosphate residues of triphospho- and diphosphonucleosides such as ATP and ADP, respectively. Before the cloning of the gene, the common name apyrase was generally used for enzymes that exhibit this activity in plants and invertebrates while the terms ecto-ATPase and ATP diphosphohydrolase (ATPDase) were rather used in vertebrates. Shortly after cloning the first gene encoding such an enzyme, the nomenclature was unified in mammals to NTPDase, which better reflects the ability of these enzymes to convert not only ATP and ADP, but also other triphospho- and diphosphonucleosides.
A first apyrase was discovered in potato...
- Sévigny J, Sundberg C, Braun N, Guckelberger O, Csizmadia E, Qawi I, et al. Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation. Blood. 2002;99(8):2801–9.PubMedCrossRefGoogle Scholar
- Zimmermann H, Beaudoin AR, Bollen M, W. GJ, Guidotti G, Kirley TL, et al., editors. Proposed nomenclature for two novel nucleotide hydrolyzing enzyme families expressed on the cell surface. Proceedings of the Second International Workshop on Ecto-ATPases and Related Ectonucleotidases; 1999/2000; Diepenbeek, Belgium\Maastricht: Shaker; 2000Google Scholar