Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi


  • Adrienn Angyal
  • Endre Kiss-Toth
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_135



Historical Background

Discovery of Tribbles Genes

Advances in large scale sequencing projects (both cDNA and genome sequencing) combined with the advent of high throughput analytical approaches to detect the targets of certain genes and the molecular consequences of cellular stimulation led to the identification of a number of genes previously unknown to science. A good example of such genes is the tribbles family, where a number of independent strands of research recognized these genes as important regulators and/or targets of cellular function in a range of biological systems.

The name tribbles (TRIB) dates back to a string of papers that published the identification of a novel gene, controlling cell division in early Drosophila development. These reports defined an important regulatory role for tribbles in cell cycle progression during the closure of the ventral furrow (Grosshans and Wieschaus 2000), gastrulation (Seher and Leptin 2000), and...

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Cardiovascular ScienceUniversity of SheffieldSheffieldUK