Fundamental Toxicology Methods and Resources for Assessing Water-relatedContamination

  • Keith R. Cooper
Reference work entry


This chapter provides a brief overview of basic toxicological methods and approaches which can be used by engineers in the field to make a rapid environmental risk determination. In addition, Internet sites which deal with specific contaminants, standard operating procedures, and methods for assessing deleterious effects on organisms living and depending on ecosystem resources are provided.


Trophic Level Methyl Mercury Hazard Quotient Ecological Risk Assessment Acid Volatile Sulfide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. P. Birak, K. Yurk et al. Travis and Arms revisited: a look at a widely used bioconcentration algorithm. Toxicol. Ind. Health 17, 163 (2001)CrossRefGoogle Scholar
  2. L. Brown, Plan B (Earth Policy Institute, Norton, New York and London, 2003), p. 283Google Scholar
  3. L. Brown, M. Renner, C. Flavin, Vital Signs (World Watch Institute, Norton, New York and London, 1998), p. 207Google Scholar
  4. M.F. Buchman, NOAA screening quick reference tables, NOAA HAZMAT Report 99–1, Coastal Protection and Restoration Division, National Oceanic and Atmospheric Administration, Seattle, 1999, pp. 1–12Google Scholar
  5. W.G. Burgess, M.A. Hoque, H.A. Michael et al., Vulnerability of deep groundwater in the Bengal Aquifer System to contamination by arsenic. Nat. Geosci. pp. 83–87 (2010). doi:10.1038/NGE0750Google Scholar
  6. M. Crane, M.C. Newman, What level of effect is a no observed effect?. Environ. Toxicol. Chem. 19, 516 (2000)CrossRefGoogle Scholar
  7. F. Dang, W.X. Wang, Antagonistic interaction of mercury and selenium in a marine fish is dependent on their chemical species. Environ. Sci. Technol. 45, 3116 (2011)CrossRefGoogle Scholar
  8. R.T. Di Giulio, M.C. Newman, Ecotoxicology, in Toxicology: The Basic Science of Poisons, 7th edn., ed. by C.D. Klaassen (McGraw-Hill, Health Profession Division, New York, 2008), pp. 1157–1187Google Scholar
  9. D.M. DiToro, J.D. Mahoney, et al. Toxicity of Cadmium in Sediments: The Role of Acid Volatile Sulfide. Environ. Toxicol. Chem. 9, 98 (1990)Google Scholar
  10. D. DiToro et al., Acid volatile sulfide predicts the acute toxicity of cadmium and nickel in sediments. EST. 26, 96 (1992)CrossRefGoogle Scholar
  11. D.L. Eaton, S.G. Gilbert, Principles of toxicology, in Toxicology: The Basic Science of Poisons, 7th edn., ed. by C.D. Klaassen (McGraw-Hill, Health Profession Division, New York, 2008), pp. 11–44Google Scholar
  12. A. Edwards, The Sustainability Revolution: Portrait of a Paradigm Shift. New Society Publishers, Philadelphia, 207p (2005)Google Scholar
  13. E.M. Faustman, G.S. Omenn, Risk assessment, in Toxicology: The Basic Science of Poisons, 7th edn., ed. by C.D. Klaassen (McGraw-Hill, Health Profession Division, New York, 2008), pp. 107–127Google Scholar
  14. R.E. Grumbine, J. Xu, Mekong hydropower development. Science 332, 178 (2011)CrossRefGoogle Scholar
  15. J.N. Huckins, SPMD technology (2002),
  16. S.E. Jorgensen et al., Handbook of Ecological Parameters and Ecotoxicology (Elsevier, Amsterdam, 1991)Google Scholar
  17. L.D. Lehman-McKeeman, Absorption, distribution and excretion of toxicants, in Toxicology: The Basic Science of Poisons, 7th edn., ed. by C.D. Klaassen (McGraw-Hill, Health Profession Division, New York, 2008), pp. 131–157Google Scholar
  18. B.G. Loganathan, K. Kannan, Global organochlorine contamination trends: an overview. Ambio 23, 187–191 (1994)Google Scholar
  19. W.K. Lyman, Transport and transformation process, in Fundamentals of Aquatic Toxicology, ed. by G.M. Rand (Taylor and Francis, London, 1995), pp. 449–492Google Scholar
  20. W.J. Lyman et al. Handbook of Chemical Property Estimation Methods: Environmental Behavior of Organic Compounds (McGraw-Hill, New York, 1982)Google Scholar
  21. D.D. MacDonald et al. Development and evaluation of consensus based sediment quality guidelines for freshwater ecosystems. Arch. Environ. Contam. Toxicol. 39, 20 (2000)CrossRefGoogle Scholar
  22. M.C. Newman, M.A. Unger, Fundamentals of Ecotoxicology, 2nd edn. (CRC/Lewis Press, Boca Raton, 2003)Google Scholar
  23. J.A. Peterson, A.V. Nebeker, Estimation of waterborne selenium concentrations that are toxicity thresholds for wildlife. Arch. Environ. Contam. Toxicol. 23, 154 (1992)CrossRefGoogle Scholar
  24. J.D. Petty et al., Considerations involved with the use of semi permeable membrane devices for monitoring environmental contaminants. J. Chromatogr. A 879, 83 (2000)CrossRefGoogle Scholar
  25. G.M. Rand et al., Introduction, in Fundamentals of Aquatic Toxicology, ed. by G.M. Rand (Taylor and Francis, London, 1995), pp. 3–66Google Scholar
  26. B.E. Sample, G.W. Suter II, Estimating Exposure of Terrestrial Wildlife to Contaminants (Oak Ridge National Laboratory, Oak Ridge, 1994) ES/ER?TM-125Google Scholar
  27. B.E. Sample et al. Toxicological Benchmarks for Screening Contaminants for Wildlife (Oak Ridge National Laboratory, Oak Ridge, 1996), 227pp. ES/ER/TM-86/R3Google Scholar
  28. B.E. Sample, et al., Methods and tools for estimation of the exposure of terrestrial wildlife to contaminants. Oak Ridge National Laboratory, Oak Ridge TN. ORNL/TM-13391 (1997)Google Scholar
  29. M. Scheringer, Long-range transport of organic chemicals in the environment. Environ. Toxicol. Chem. 28, 677 (2009)CrossRefGoogle Scholar
  30. R.P. Schwarzenbach et al., Partitioning to living media-bioaccumulation and baseline toxicity, in Environmental Organic Chemistry, 2nd edn., ed. by R.P. Schwarzenbach et al. (Wiley, Hoboken, 2003) pp. 331–386Google Scholar
  31. A. Spacie et al., Bioaccumulation and bioavailability in multiphase systems, in Fundamentals of Aquatic Toxicology, ed. by G.M. Rand (Taylor and Francis, London, 1995), pp. 493–521Google Scholar
  32. J.B. Sprague, Factors that modify toxicity in Fundamentals of Aquatic Toxicology ed. by G.M. Rand, S.R. Petrocelli (Hemisphere Publishing Corporation, Washington, 1985), pp. 124–163Google Scholar
  33. H. Sun et al., Temporal aggregation of interpolated daily climate grids: An error assessment. Environ. Toxicol. Chem. 27, 103 (2008)CrossRefGoogle Scholar
  34. G.W. Suter, Ecological Risk Assessment (Lewis, Boca Raton, 1993)Google Scholar
  35. G.W. Suter, Introduction to ecological risk assessment for aquatic toxic effects, in Fundamentals of Aquatic Toxicology, ed. by G.M. Rand (Taylor and Francis, London, 1998) pp. 803–816Google Scholar
  36. C.C. Travis, A.D. Arms, Bioconcentration of organics in beef, milk, and vegetation. Environmental Science and Technology 22, 271 (1988)Google Scholar
  37. US Environmental Protection Agency (USEPA), Framework for ecological risk assessment, Washington D.C., 1992, EPA/630/R-92/001Google Scholar
  38. US Environmental Protection Agency (USEPA), Wildlife exposure factors handbook, Volume 1 office of research and development, Washington D.C., 1993, EPA/600/R-93/187aGoogle Scholar
  39. US Environmental Protection Agency (USEPA), Guidelines for Ecological Risk Assessment. U.S. Environmental Protection Agency, Risk Assessment Forum, Washington, DC, EPA/630/R095/002F, DRAFT 1995 FINAL 1998Google Scholar
  40. US Environmental Protection Agency (USEPA), Great lakes water quality initiative criteria documents for the protection of wildlife, Washington D.C., 1995, EPA-820-B-95–008Google Scholar
  41. US Environmental Protection Agency (USEPA), Ecological risk assessment guidance for superfund: process for designing and conducting ecological risk assessments, Interm Final, USEPA, Edison, 1997a, EPA 540-R-97–006Google Scholar
  42. US Environmental Protection Agency (USEPA), Mercury study report to congress, Vol VII: characterization of human health and wildlife risks from mercury exposure in the United States, Washington D.C., 1997b, EPA-452/R-97–009Google Scholar
  43. US Environmental Protection Agency (USEPA), U.S. environmental protection agency, risk assessment forum, Washington, D.C., 1998, EPA/630/R095/002FGoogle Scholar
  44. US Environmental Protection Agency (USEPA), Guidance for the development of ecological soil screening levels. Office of Solid Waste and Emergency Response, Washington, D.C., 2003; OSWER Directive 92857–55Google Scholar
  45. US Environmental Protection Agency (USEPA), Framework for metals risk assessment (2007),
  46. M. Van den Berg, et al. The 2005 World Health Organization Re-evaluation of Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-like Compounds. Toxicol. Sci. 93, 223 (2008)CrossRefGoogle Scholar
  47. Wada et al. Global depletion of groundwater resources. Geophys. Res. Lett. 37, L20402 (2010). doi:10.1029/2010GL044571Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Keith R. Cooper
    • 1
  1. 1.Department of Biochemistry & Microbiology, RutgersThe State University of NJNew BrunswickUSA

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