The first rabies vaccine was introduced as early as 1885 by Louis Pasteur. Since 1967, a vaccine produced from human diploids has been available. The rabies vaccination containing a vaccine made from dead viruses is suitable for persons who are at high risk for infection due to their profession or due to traveling. The vaccine is well tolerated, and is given on days 0, 7 and 28, producing almost 100% protection. The first booster is given one year later, followed by further boosters every 2–5 years.