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Single Molecule Microscopy

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Soft Matter Characterization

1 Introduction

Biomolecules such as proteins and nucleic acids interact and assemble to perform various functions in cells. The functions of biomolecules include controls of the transcription of genetic information, synthesis and folding of biomolecules, the movement and structural changes of cells, transportation of small vesicles and materials within cells, and signal transduction in response to external stimuli. Using molecular biology techniques, the molecules involved in these functions have been identified and the structures of these molecules have been determined using structural biology tools. Based on the information thus obtained, the mechanism of biomolecules and the assembly of biomolecules called molecular machines have been explored. In addition to these techniques, the detection techniques of single biomolecules which are of the order of nanometers have been developed as new and unique experimental tools to describe the behavior of biomolecules.

The pioneer experiment of...

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Author information

Authors and Affiliations

  1. Osaka University, Osaka, Japan

    Y. Ishii

  2. Japan Science & Technology Agency, Osaka, Japan

    J. Kozuka

  3. Osaka University, Osaka, Japan

    S. Esaki

  4. Osaka University, Osaka, Japan

    T. Yanagida

Authors
  1. Y. Ishii
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  2. J. Kozuka
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  3. S. Esaki
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  4. T. Yanagida
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Editor information

Editors and Affiliations

  1. CERMAV, CNRS-UPR 5301 and Joseph Fourier University, Grenoble Cedex 9, France

    Redouane Borsali

  2. Department of Chemistry, University of California - Stanford Stauffer II, 375 North-South Mall, 94305-5080, Stanford, CA, USA

    Robert Pecora (Professor) (Professor)

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Ishii, Y., Kozuka, J., Esaki, S., Yanagida, T. (2008). Single Molecule Microscopy. In: Borsali, R., Pecora, R. (eds) Soft Matter Characterization. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-4465-6_24

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