Virion
Morphology: |
Icosahedral |
Envelope: |
Yes |
Diameter (nm): |
160–200 |
Length (nm): |
– |
Structural components: |
Envelope, tegument, capsid, core |
Buoyant density (g/mL): |
1.273 |
Buoyant density method: |
|
Lipid composition: |
|
Additional information: |
Genome
Nucleic acid: |
DNA |
|
Strandedness: |
Double-stranded |
|
Polarity: |
– |
|
Configuration: |
Linear |
|
Segment organization: |
Segment no. 1 (kb): |
140–170 |
One segment(s): |
140–170 (kb) total (calculated) |
|
G + C content (%): |
43%, 36% |
|
mRNA Transcripts: |
>100 |
|
Open reading frames: |
100–110 |
|
Additional information: |
Limited overlap between adjacent open reading frames |
|
Replication
Entry mechanism: |
Receptor-mediated endocytosis, membrane fusion |
Site of transcription: |
Nucleus |
Transcriptase: |
Cellular RNA polymerase |
Site of genome replication: |
Nucleus |
Replicase: |
Virus-encoded DNA-dependent DNA polymerase |
Replication intermediate: |
Unknown |
Site of virion assembly: |
Nucleus |
Egress mechanism: |
Exocytosis or cell lysis |
Additional information: |
HHV-6 can integrate into host chromosomal DNA |
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References
Frenkel N et al (1990) Isolation of a new herpesvirus from human CD4+ T cells. Proc Natl Acad Sci USA 87:748–752
Frenkel N, Roffman E (1996) In: Fields BN et al (eds) Virology, 3rd edn. Raven Press, New York, pp 2609–2622
Pellet PE, Black JB (1996) In: Fields BN et al (eds) Virology, 3rd edn. Raven Press, New York, pp 2587–2608
Salahuddin SZ et al (1986) Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234:596–601
Santoro F et al (1999) CD46 is a cellular receptor for human herpesvirus 6. Cell 99:817–27
Yamanishi K et al (1988) Identification of human herpesvirus 6 as a causal agent for exanthem subitum. Lancet I:1065–1067
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Lusso, P., Yamanishi, K. (2011). Roseolovirus. In: Tidona, C., Darai, G. (eds) The Springer Index of Viruses. Springer, New York, NY. https://doi.org/10.1007/978-0-387-95919-1_98
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DOI: https://doi.org/10.1007/978-0-387-95919-1_98
Publisher Name: Springer, New York, NY
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