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Animal Models of Autoimmune Hepatitis

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Encyclopedia of Medical Immunology

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Synonyms

Animal model; Autoantibodies; Autoimmune hepatitis; Fibrosis; Hepatic tolerance; Intrahepatic T cells; Portal infiltrates

Definition

Human autoimmune hepatitis (AIH) is characterized by specific autoantibodies, elevation of serum aminotransaminases and gamma globulins, liver histopathology suggestive of AIH, and exclusion of other chronic liver diseases. The disease requires lifelong immunosuppression in most cases. Due to limited knowledge about the onset and course of disease, because of the late diagnosis, the limited availability of liver tissue and the required chronic immunosuppression with potentially severe side effects, there is strong need for suitable animal models that reflect AIH.

Introduction

Autoimmune hepatitis (AIH) is a severe and chronic autoimmune inflammation of the liver. The disease is normally diagnosed during advanced stages of disease. Therefore, knowledge about the onset and development of disease is very limited. Therapeutic intervention involves...

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Author information

Authors and Affiliations

  1. Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, 30625, Germany

    Matthias Hardtke-Wolenski & Elmar Jaeckel

Authors
  1. Matthias Hardtke-Wolenski
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  2. Elmar Jaeckel
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Corresponding author

Correspondence to Matthias Hardtke-Wolenski .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Betty Diamond

  4. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Anne Davidson

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Hardtke-Wolenski, M., Jaeckel, E. (2014). Animal Models of Autoimmune Hepatitis. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_70

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  • DOI: https://doi.org/10.1007/978-0-387-84828-0_70

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-84827-3

  • Online ISBN: 978-0-387-84828-0

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