Synonyms
Hughes Syndrome
Definition
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by recurrent thrombotic events and pregnancy morbidity, in the presence of distinct autoantibodies. The treatment of APS should be directed to subgroups based on clinical manifestations, immunological findings, and whether accompanied by other autoimmune disease. The treatment includes anticoagulants and/or aspirin.
Treatment for Thrombosis
Recently updated criteria for APS in 2006 define the syndrome as the combination of a clinical event (including at least one thromboembolic event, pregnancy morbidity, or both) and an abnormal test result (including the presence of antibodies to cardiolipin (aCL) or beta-2-glycoprotein I (anti-b2GPI) or the presence of the lupus anticoagulant (LAC) detectable at least twice over an interval of 12 weeks or more) (Miyakis et al. 2006). Thromboses are usually recurrent and frequently involve the same territory in subsequent thrombotic events...
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Zandman-Goddard, G., Shoenfeld, Y. (2014). Antiphospholipid Syndrome Treatment. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_421
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DOI: https://doi.org/10.1007/978-0-387-84828-0_421
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