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Prebiotics and Probiotics Science and Technology pp 977–995Cite as

Probiotics and Allergy

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Abstract

The atopic diseases include atopic eczema, allergic rhinitis and asthma. The prevalence of atopic diseases has been on the rise for several decades, particularly in high-income industrialized nations (ISAAC, 1998; Sibbald et al., 1990). As potential explanations for the increased prevalence of atopic diseases the so-called hygiene hypothesis has been suggested. The hypothesis suggests that the continuously increased hygiene in the environment and the food supply results to reduced exposure to a variety of microbes and consequently to a less diverse intestinal microbiota from early life onwards and/or to changes in the gut microbiota from early life. Such changes reflect the exposure to microbes in industrially processed foods and the improved hygiene of the living environment of the mother and infant.

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References

  • Abrahamsson TR, Jakobsson T, Bottcher MF et al. (2007) Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 119:1174–1180

    Article  CAS  Google Scholar 

  • Apter AJ (2003) Early exposure to allergen: is this the cat's meow, or are we barking up the wrong tree? J Allergy Clin Immunol 111:938–946

    Article  Google Scholar 

  • von Berg A, Filipiak-Pittroff B, Krämer U et al. (2008) Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI). J Allergy Clin Immunol 121:1442–1447

    Article  Google Scholar 

  • Björkstén B, Sepp E, Julge K, Voor T, Mikelsaar M (2001) Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol 108:516–520

    Article  Google Scholar 

  • Bos JD, Kapsenberg ML, Sillevis Smitt JH (1994) Pathogenesis of atopic eczema. Lancet 343:1338–1341

    Article  CAS  Google Scholar 

  • Brouwer ML, Wolt-Plompen SA, Dubois AE et al. (2006) No effects of probiotics on atopic dermatitis in infancy: a randomized placebo-controlled trial. Clin Exp Allergy 36:899–906

    Article  CAS  Google Scholar 

  • Favier C, Vaughan E, de Vos W, Akkermans A (2002) Molecular monitoring of succession of bacterial communities in human neonates. Appl Environm Microbiol 68:219–226

    Article  CAS  Google Scholar 

  • Fölster-Holst R, Müller F, Schnopp N et al. (2006) Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis. Br J Dermatol 155:1256–1261

    Article  Google Scholar 

  • Fukaura H, Kent SC, Pietrusewitz MJ (1996) Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-b1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest 98:70–77

    Article  CAS  Google Scholar 

  • Gore C, Munro K, Lay C, Bibiloni R et al. (2008) Bifidobacterium pseudocatenulatum is associated with atopic eczema: a nested case-control study investigating the fecal microbiota of infants. J Allergy Clin Immunol 121:135–140

    Article  Google Scholar 

  • Grönlund MM, Arvilommi H, Kero P (2000) Importance of intestinal colonisation in the maturation of humoral immunity in early infancy: a prospective follow up study of healthy infants aged 0-6 months. Arch Dis Child 83:F186–192

    Google Scholar 

  • Grönlund MM, Gueimonde M, Laitinen K et al. (2008) Maternal breast-milk and intestinal bifidobacteria guide the compositional development of the Bifidobacterium microbiota in infants at risk of allergic disease. Clin Exp Allergy 2007 Oct 18

    Google Scholar 

  • Gueimonde M, Laitinen K, Salminen S, Isolauri E (2007) Breast milk: a source of bifidobacteria for infant gut development and maturation? Neonatology 92:64–66

    Article  Google Scholar 

  • Gueimonde M, Kalliomaki M, Isolauri E, Salminen S (2006) Probiotic intervention in neonates--will permanent colonization ensue? J Pediatr Gastroenterol Nutr 42:604–606

    Article  Google Scholar 

  • Hanifin JM (1984) Atopic dermatitis. J Allergy Clin Immunol 73:211–222

    Article  CAS  Google Scholar 

  • Hanifin JM (2002) Atopiform dermatitis: do we need another confusing name for atopic dermatitis? Br J Dermatol 147:430–432

    Article  CAS  Google Scholar 

  • Hartmann G, Weiner GJ, Krieg AM (1999) CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells. Proc Natl Acad Sci USA 96:9305–9319

    Article  CAS  Google Scholar 

  • Huurre A, Laitinen K, Rautava S et al. (2008) Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study. Clinical and Experimental Allergy 38:1342–1348

    Article  CAS  Google Scholar 

  • Isolauri E, Arvola T, Sütas Y (2000) Probiotics in the management of atopic eczema. Clin Exp Allergy 30:1605–1610

    Article  Google Scholar 

  • Isolauri E, Huurre A, Salminen S, Impivaara O (2004) The allergy epidemic extends beyond the past few decades. Clin Exp Allergy 34:1007–1010

    Article  CAS  Google Scholar 

  • Isolauri E, Rautava S, Kalliomäki M, Kirjavainen P, Salminen S (2002) Probiotic research: learn from the evidence. Curr Opin Immunol Clin Allergol 2:263–271

    Article  Google Scholar 

  • Isolauri E, Salminen S (2008) Probiotics. In Walker's Pediatric Gastrointestinal Diesease BC Dekker Inc, USA

    Google Scholar 

  • Isolauri E (2001) Probiotics in human disease. Am J Clin Nutr 73:1142S–1146S

    CAS  Google Scholar 

  • Johansson S, Hourihane J, Bousquet J (2001) A revised nomenclature for allergy. Allergy 56:813–824

    Article  CAS  Google Scholar 

  • Jones CA, Holloway JA, Popplewell EJ (2002) Reduced soluble CD14 levels in amniotic fluid and breast milk are associated with the subsequent development of atopy, eczema, or both. J Allergy Clin Immunol 109:858–866

    Article  CAS  Google Scholar 

  • Juntunen M, Kirjavainen P, Ouwehand AC et al. (2003) Gut microflora changes and probiotics in children in day care centers. Bioscience and Microflora 22:155–157

    Google Scholar 

  • Kalliomäki M, Collado MC, Salminen S, Isolauri E (2008) Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am J Clin Nutr 87:534–538

    Google Scholar 

  • Kalliomäki M, Kirjavainen P, Eerola E et al. (2001a) Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol 107:129–134

    Article  Google Scholar 

  • Kalliomäki M, Ouwehand A, Arvilommi H (1999) Transforming growth factor-beta in breast milk: a potential regulator of atopic disease at an early age. J Allergy Clin Immunol 104:1251–1257

    Article  Google Scholar 

  • Kalliomäki M, Salminen S, Kero P et al. (2001b) Probiotics in the primary prevention of atopic disease: a randomised, placebo-controlled trial. Lancet 357:1076–1079

    Article  Google Scholar 

  • Kalliomäki M, Salminen S, Poussa T, Arvilommi H, Isolauri E (2003) Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet 361:1869–1871

    Article  Google Scholar 

  • Kalliomäki M, Salminen S, Poussa T, Isolauri E (2007) Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. J Allergy Clin Immunol 119:1019–1021

    Article  Google Scholar 

  • Kirjavainen PV, Salminen SJ, Isolauri E (2003) Probiotic bacteria in the management of atopic disease: underscoring the importance of viability. J Pediatr Gastroenterol Nutr 36:223–227

    Article  Google Scholar 

  • Kopp M, Hennemuth I, Heinzmann et al. (2008) Randomized, double-blind, placebo-controlled trial of probiotics for primary prevention: no clinical effects of Lactobacillus GG supplementation. Pediatrics 121;e850–e856

    Article  Google Scholar 

  • Kukkonen K, Savilahti E, Haahtela T et al. (2008) Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 119:192–198

    Article  Google Scholar 

  • Kulig M, Bergmann R, Klettke U, Wahn V, Tacke U, Wahn U (1999) Natural course of sensitization to food and inhalant allergens during the first 6 years of life. J Allergy Clin Immunol 103:1173–1179

    Article  CAS  Google Scholar 

  • Kulig M, Tacke U, Forster J et al. (1999) Serum IgE levels during the first 6 years of life. J Pediatr 134:453–458

    Article  CAS  Google Scholar 

  • Lau S, Illi S, Sommerfeld C (2000) Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. Lancet 356:1392–1397

    Article  CAS  Google Scholar 

  • Leung DYM, Bieber T (2003) Atopic dermatitis. Lancet 361:151–160

    Article  Google Scholar 

  • Majamaa H, Isolauri E (1997) Probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol 99:179–186

    Article  CAS  Google Scholar 

  • Martín R, Langa S, Reviriego C et al. (2003) Human milk is a source of lactic acid bacteria for the infant gut. J Pediatr 143:754–758

    Article  Google Scholar 

  • Nakagawa T, Nakagomi T, Hisamatsu S, Itaya H, Nakagomi O, Mizushima Y (1996) J Allergy Clin Immunol 97:1165–1166

    Article  CAS  Google Scholar 

  • Neish AS, Gewirtz AT, Zeng H (2000) Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination. Science 289:1560–1563

    Article  CAS  Google Scholar 

  • Novak N, Bieber T, Leung DYM (2003) Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. J Allergy Clin Immunol 112:S128–139

    Article  CAS  Google Scholar 

  • Novak N, Bieber T, Leung DY (2003) Immune mechanisms leading to atopic dermatitis. J Allergy Clin Immunol 112:252–262

    Article  Google Scholar 

  • Penders J, Stobberingh EE, Thijs C et al. (2006) Molecular fingerprinting of the intestinal microbiota of infants in whom atopic eczema was or was not developing. Clin Exp Allergy 36:1602–1608

    Article  CAS  Google Scholar 

  • Pepys J (1994) Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination. Allergy 49:397–399

    Article  CAS  Google Scholar 

  • Repa A, Kozakova H, Hudcovic T et al. (2008) Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microflora. Immunol Lett 117:50–56

    Article  CAS  Google Scholar 

  • Rautava S, Kalliomäki M, Isolauri E (2002) Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease inthe infant. J Allergy Clin Immunol 109:119–121

    Article  Google Scholar 

  • Rinne M, Gueimonde M, Kalliomäki M, Hoppu U, Salminen S, Isolauri E (2005) Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota. FEMS Immunol Med Microbiol 43:59–65

    Article  CAS  Google Scholar 

  • Riedler J, Braun-Fahrländer C, Eder W (2001) Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 358:1129–1133

    Article  CAS  Google Scholar 

  • Rosenfeldt V, Benfeldt E, Dam Nielsen S (2003) Effect of probiotic Lactobacillus strains in children with atopic dermatitis. J Allergy Clin Immunol 111:389 –395

    Article  Google Scholar 

  • Salminen S, Bouley C, Boutron-Ruault MC (1998) Gastrointestinal physiology and function - targets for functional food development. Br J Nutr 80(suppl):147–171

    Article  Google Scholar 

  • Salminen S, Gueimonde M (2005) Gut Microbiota in Infants between 6 and 24 Months of Age. Nestle Nutr Workshop Ser Pediatr Program 56:43–56

    Article  Google Scholar 

  • Salminen S, Isolauri E (2006) Probiotics, gut inflammation and barrier function. Pediatr 149:S115–120

    Article  CAS  Google Scholar 

  • Satokari R, Grönroos T, Laitinen K et al. (2009) Bifidobacterium and Lactobacillus DNA in the human placenta. Lett Appl Microbiol 48:8–12

    Article  CAS  Google Scholar 

  • Sibbald B, Rink E, D'Souza M (1990) Is the prevalence of atopy increasing? Br J Gen Practice 40:338–340

    CAS  Google Scholar 

  • Sistek D, Kelly R, Wickens K, Stanley T et al. (2006) Is the effect of probiotics on atopic dermatitis confined to food sensitized children? Clin Exp Allergy 36:629–633

    Article  CAS  Google Scholar 

  • Strachan DP (1989) Hay fever, hygiene, and household size. BMJ 299:1259–1260

    Article  CAS  Google Scholar 

  • Sudo N, Sawamura S, Tanaka K (1997) The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 159:1739–1745

    CAS  Google Scholar 

  • Taylor A, Hale J, Wiltschut J et al. (2006) Effects of probiotic supplementation for the first 6 months of life on allergen- and vaccine-specific immune responses. Clinical and Experimental Allergy 36:1227–1235

    Article  CAS  Google Scholar 

  • Taylor AL, Dunstan JA, Prescott SL (2007) Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial. J Allergy Clin Immunol 119:184–191

    Article  Google Scholar 

  • Vicini J, Etherton T, Kris-Etherton P et al. (2008) Survey of retail milk composition as affected by label claims regarding farm-management practices. J Am Diet Ass 108:1198–1203

    Article  Google Scholar 

  • Viljanen M, Savilahti E, Haahtela T et al. (2005) Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial. Allergy 60:494–500

    Article  CAS  Google Scholar 

  • Wen L, Ley RE, Volchkov PY et al. (2008) Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 455:1109–1113

    Article  CAS  Google Scholar 

  • Weston S, Halbert A, Richmond P, Prescott SL (2005) Effects of probiotics on atopic dermatitis: a randomised controlled trial. Arch Dis Child 90:892–897

    Article  CAS  Google Scholar 

  • Wickens K, Black PN, Stanley TV et al. (2008) A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 122:788–794

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Functional Foods Forum, University of Turku, 20014, Turku, Finland

    Seppo Salminen & Erika Isolauri

  2. Department of Paediatrics, University of Turku and Turku University Central Hospital, Turku, Finland

    Seppo Salminen & Erika Isolauri

Authors
  1. Seppo Salminen
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  2. Erika Isolauri
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Editors and Affiliations

  1. Department of Food Biosciences, University of Reading Whiteknights, Reading, UK

    Dimitris Charalampopoulos  & Robert A. Rastall  & 

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Salminen, S., Isolauri, E. (2009). Probiotics and Allergy. In: Charalampopoulos, D., Rastall, R.A. (eds) Prebiotics and Probiotics Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79058-9_25

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