Probiotics and Allergy

  • Seppo Salminen
  • Erika Isolauri
Reference work entry


The atopic diseases include atopic eczema, allergic rhinitis and asthma. The prevalence of atopic diseases has been on the rise for several decades, particularly in high-income industrialized nations (ISAAC, 1998; Sibbald et al., 1990). As potential explanations for the increased prevalence of atopic diseases the so-called hygiene hypothesis has been suggested. The hypothesis suggests that the continuously increased hygiene in the environment and the food supply results to reduced exposure to a variety of microbes and consequently to a less diverse intestinal microbiota from early life onwards and/or to changes in the gut microbiota from early life. Such changes reflect the exposure to microbes in industrially processed foods and the improved hygiene of the living environment of the mother and infant.


Atopic Eczema Lactic Acid Bacterium Intestinal Microbiota Atopic Disease Microbiota Composition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Abrahamsson TR, Jakobsson T, Bottcher MF et al. (2007) Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 119:1174–1180CrossRefGoogle Scholar
  2. Apter AJ (2003) Early exposure to allergen: is this the cat's meow, or are we barking up the wrong tree? J Allergy Clin Immunol 111:938–946CrossRefGoogle Scholar
  3. von Berg A, Filipiak-Pittroff B, Krämer U et al. (2008) Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI). J Allergy Clin Immunol 121:1442–1447CrossRefGoogle Scholar
  4. Björkstén B, Sepp E, Julge K, Voor T, Mikelsaar M (2001) Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol 108:516–520CrossRefGoogle Scholar
  5. Bos JD, Kapsenberg ML, Sillevis Smitt JH (1994) Pathogenesis of atopic eczema. Lancet 343:1338–1341CrossRefGoogle Scholar
  6. Brouwer ML, Wolt-Plompen SA, Dubois AE et al. (2006) No effects of probiotics on atopic dermatitis in infancy: a randomized placebo-controlled trial. Clin Exp Allergy 36:899–906CrossRefGoogle Scholar
  7. Favier C, Vaughan E, de Vos W, Akkermans A (2002) Molecular monitoring of succession of bacterial communities in human neonates. Appl Environm Microbiol 68:219–226CrossRefGoogle Scholar
  8. Fölster-Holst R, Müller F, Schnopp N et al. (2006) Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis. Br J Dermatol 155:1256–1261CrossRefGoogle Scholar
  9. Fukaura H, Kent SC, Pietrusewitz MJ (1996) Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-b1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest 98:70–77CrossRefGoogle Scholar
  10. Gore C, Munro K, Lay C, Bibiloni R et al. (2008) Bifidobacterium pseudocatenulatum is associated with atopic eczema: a nested case-control study investigating the fecal microbiota of infants. J Allergy Clin Immunol 121:135–140CrossRefGoogle Scholar
  11. Grönlund MM, Arvilommi H, Kero P (2000) Importance of intestinal colonisation in the maturation of humoral immunity in early infancy: a prospective follow up study of healthy infants aged 0-6 months. Arch Dis Child 83:F186–192Google Scholar
  12. Grönlund MM, Gueimonde M, Laitinen K et al. (2008) Maternal breast-milk and intestinal bifidobacteria guide the compositional development of the Bifidobacterium microbiota in infants at risk of allergic disease. Clin Exp Allergy 2007 Oct 18Google Scholar
  13. Gueimonde M, Laitinen K, Salminen S, Isolauri E (2007) Breast milk: a source of bifidobacteria for infant gut development and maturation? Neonatology 92:64–66CrossRefGoogle Scholar
  14. Gueimonde M, Kalliomaki M, Isolauri E, Salminen S (2006) Probiotic intervention in neonates--will permanent colonization ensue? J Pediatr Gastroenterol Nutr 42:604–606CrossRefGoogle Scholar
  15. Hanifin JM (1984) Atopic dermatitis. J Allergy Clin Immunol 73:211–222CrossRefGoogle Scholar
  16. Hanifin JM (2002) Atopiform dermatitis: do we need another confusing name for atopic dermatitis? Br J Dermatol 147:430–432CrossRefGoogle Scholar
  17. Hartmann G, Weiner GJ, Krieg AM (1999) CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells. Proc Natl Acad Sci USA 96:9305–9319CrossRefGoogle Scholar
  18. Huurre A, Laitinen K, Rautava S et al. (2008) Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study. Clinical and Experimental Allergy 38:1342–1348CrossRefGoogle Scholar
  19. Isolauri E, Arvola T, Sütas Y (2000) Probiotics in the management of atopic eczema. Clin Exp Allergy 30:1605–1610CrossRefGoogle Scholar
  20. Isolauri E, Huurre A, Salminen S, Impivaara O (2004) The allergy epidemic extends beyond the past few decades. Clin Exp Allergy 34:1007–1010CrossRefGoogle Scholar
  21. Isolauri E, Rautava S, Kalliomäki M, Kirjavainen P, Salminen S (2002) Probiotic research: learn from the evidence. Curr Opin Immunol Clin Allergol 2:263–271CrossRefGoogle Scholar
  22. Isolauri E, Salminen S (2008) Probiotics. In Walker's Pediatric Gastrointestinal Diesease BC Dekker Inc, USAGoogle Scholar
  23. Isolauri E (2001) Probiotics in human disease. Am J Clin Nutr 73:1142S–1146SGoogle Scholar
  24. Johansson S, Hourihane J, Bousquet J (2001) A revised nomenclature for allergy. Allergy 56:813–824CrossRefGoogle Scholar
  25. Jones CA, Holloway JA, Popplewell EJ (2002) Reduced soluble CD14 levels in amniotic fluid and breast milk are associated with the subsequent development of atopy, eczema, or both. J Allergy Clin Immunol 109:858–866CrossRefGoogle Scholar
  26. Juntunen M, Kirjavainen P, Ouwehand AC et al. (2003) Gut microflora changes and probiotics in children in day care centers. Bioscience and Microflora 22:155–157Google Scholar
  27. Kalliomäki M, Collado MC, Salminen S, Isolauri E (2008) Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am J Clin Nutr 87:534–538Google Scholar
  28. Kalliomäki M, Kirjavainen P, Eerola E et al. (2001a) Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol 107:129–134CrossRefGoogle Scholar
  29. Kalliomäki M, Ouwehand A, Arvilommi H (1999) Transforming growth factor-beta in breast milk: a potential regulator of atopic disease at an early age. J Allergy Clin Immunol 104:1251–1257CrossRefGoogle Scholar
  30. Kalliomäki M, Salminen S, Kero P et al. (2001b) Probiotics in the primary prevention of atopic disease: a randomised, placebo-controlled trial. Lancet 357:1076–1079CrossRefGoogle Scholar
  31. Kalliomäki M, Salminen S, Poussa T, Arvilommi H, Isolauri E (2003) Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet 361:1869–1871CrossRefGoogle Scholar
  32. Kalliomäki M, Salminen S, Poussa T, Isolauri E (2007) Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. J Allergy Clin Immunol 119:1019–1021CrossRefGoogle Scholar
  33. Kirjavainen PV, Salminen SJ, Isolauri E (2003) Probiotic bacteria in the management of atopic disease: underscoring the importance of viability. J Pediatr Gastroenterol Nutr 36:223–227CrossRefGoogle Scholar
  34. Kopp M, Hennemuth I, Heinzmann et al. (2008) Randomized, double-blind, placebo-controlled trial of probiotics for primary prevention: no clinical effects of Lactobacillus GG supplementation. Pediatrics 121;e850–e856CrossRefGoogle Scholar
  35. Kukkonen K, Savilahti E, Haahtela T et al. (2008) Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 119:192–198CrossRefGoogle Scholar
  36. Kulig M, Bergmann R, Klettke U, Wahn V, Tacke U, Wahn U (1999) Natural course of sensitization to food and inhalant allergens during the first 6 years of life. J Allergy Clin Immunol 103:1173–1179CrossRefGoogle Scholar
  37. Kulig M, Tacke U, Forster J et al. (1999) Serum IgE levels during the first 6 years of life. J Pediatr 134:453–458CrossRefGoogle Scholar
  38. Lau S, Illi S, Sommerfeld C (2000) Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. Lancet 356:1392–1397CrossRefGoogle Scholar
  39. Leung DYM, Bieber T (2003) Atopic dermatitis. Lancet 361:151–160CrossRefGoogle Scholar
  40. Majamaa H, Isolauri E (1997) Probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol 99:179–186CrossRefGoogle Scholar
  41. Martín R, Langa S, Reviriego C et al. (2003) Human milk is a source of lactic acid bacteria for the infant gut. J Pediatr 143:754–758CrossRefGoogle Scholar
  42. Nakagawa T, Nakagomi T, Hisamatsu S, Itaya H, Nakagomi O, Mizushima Y (1996) J Allergy Clin Immunol 97:1165–1166CrossRefGoogle Scholar
  43. Neish AS, Gewirtz AT, Zeng H (2000) Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination. Science 289:1560–1563CrossRefGoogle Scholar
  44. Novak N, Bieber T, Leung DYM (2003) Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. J Allergy Clin Immunol 112:S128–139CrossRefGoogle Scholar
  45. Novak N, Bieber T, Leung DY (2003) Immune mechanisms leading to atopic dermatitis. J Allergy Clin Immunol 112:252–262CrossRefGoogle Scholar
  46. Penders J, Stobberingh EE, Thijs C et al. (2006) Molecular fingerprinting of the intestinal microbiota of infants in whom atopic eczema was or was not developing. Clin Exp Allergy 36:1602–1608CrossRefGoogle Scholar
  47. Pepys J (1994) Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination. Allergy 49:397–399CrossRefGoogle Scholar
  48. Repa A, Kozakova H, Hudcovic T et al. (2008) Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microflora. Immunol Lett 117:50–56CrossRefGoogle Scholar
  49. Rautava S, Kalliomäki M, Isolauri E (2002) Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease inthe infant. J Allergy Clin Immunol 109:119–121CrossRefGoogle Scholar
  50. Rinne M, Gueimonde M, Kalliomäki M, Hoppu U, Salminen S, Isolauri E (2005) Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota. FEMS Immunol Med Microbiol 43:59–65CrossRefGoogle Scholar
  51. Riedler J, Braun-Fahrländer C, Eder W (2001) Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 358:1129–1133CrossRefGoogle Scholar
  52. Rosenfeldt V, Benfeldt E, Dam Nielsen S (2003) Effect of probiotic Lactobacillus strains in children with atopic dermatitis. J Allergy Clin Immunol 111:389 –395CrossRefGoogle Scholar
  53. Salminen S, Bouley C, Boutron-Ruault MC (1998) Gastrointestinal physiology and function - targets for functional food development. Br J Nutr 80(suppl):147–171CrossRefGoogle Scholar
  54. Salminen S, Gueimonde M (2005) Gut Microbiota in Infants between 6 and 24 Months of Age. Nestle Nutr Workshop Ser Pediatr Program 56:43–56CrossRefGoogle Scholar
  55. Salminen S, Isolauri E (2006) Probiotics, gut inflammation and barrier function. Pediatr 149:S115–120CrossRefGoogle Scholar
  56. Satokari R, Grönroos T, Laitinen K et al. (2009) Bifidobacterium and Lactobacillus DNA in the human placenta. Lett Appl Microbiol 48:8–12CrossRefGoogle Scholar
  57. Sibbald B, Rink E, D'Souza M (1990) Is the prevalence of atopy increasing? Br J Gen Practice 40:338–340Google Scholar
  58. Sistek D, Kelly R, Wickens K, Stanley T et al. (2006) Is the effect of probiotics on atopic dermatitis confined to food sensitized children? Clin Exp Allergy 36:629–633CrossRefGoogle Scholar
  59. Strachan DP (1989) Hay fever, hygiene, and household size. BMJ 299:1259–1260CrossRefGoogle Scholar
  60. Sudo N, Sawamura S, Tanaka K (1997) The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 159:1739–1745Google Scholar
  61. Taylor A, Hale J, Wiltschut J et al. (2006) Effects of probiotic supplementation for the first 6 months of life on allergen- and vaccine-specific immune responses. Clinical and Experimental Allergy 36:1227–1235CrossRefGoogle Scholar
  62. Taylor AL, Dunstan JA, Prescott SL (2007) Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial. J Allergy Clin Immunol 119:184–191CrossRefGoogle Scholar
  63. Vicini J, Etherton T, Kris-Etherton P et al. (2008) Survey of retail milk composition as affected by label claims regarding farm-management practices. J Am Diet Ass 108:1198–1203CrossRefGoogle Scholar
  64. Viljanen M, Savilahti E, Haahtela T et al. (2005) Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial. Allergy 60:494–500CrossRefGoogle Scholar
  65. Wen L, Ley RE, Volchkov PY et al. (2008) Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 455:1109–1113CrossRefGoogle Scholar
  66. Weston S, Halbert A, Richmond P, Prescott SL (2005) Effects of probiotics on atopic dermatitis: a randomised controlled trial. Arch Dis Child 90:892–897CrossRefGoogle Scholar
  67. Wickens K, Black PN, Stanley TV et al. (2008) A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 122:788–794CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Seppo Salminen
    • 1
    • 2
  • Erika Isolauri
    • 1
    • 2
  1. 1.Functional Foods ForumUniversity of TurkuTurkuFinland
  2. 2.Department of PaediatricsUniversity of Turku and Turku University Central HospitalTurkuFinland

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