Advertisement

The Disease Burden Due to Epilepsy in Rural China

  • D. Ding
  • W. Z. Wang
  • Z. Hong
Reference work entry

Abstract:

The World Health Organization (WHO), in cooperation with the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) launched the Global Campaign Against Epilepsy (GCAE) in an attempt to bring epilepsy “out of the shadows” and to improve the acceptability, treatment, services and prevention of epilepsy world-wide. As part of this campaign and under the auspices of the WHO and the Ministry of Health of China, a demonstration project was implemented in rural areas in six non-contiguous provinces of the People’s Republic of China (PRC). In the sample areas, the lifetime prevalence and prevalence of  active epilepsy in rural China were 6.0–7.0/1,000 and 3.8–4.6/1,000 respectively. Sixty-three percent of people with active epilepsy had not received antiepileptic medication in the week before the survey (i.e., the  treatment gap was 63%). The disease burden of epilepsy was measured as 2.08 Disability Adjusted Life Years ( DALYs) lost per 1,000 population. The  standardized mortality ratio (SMR) of people with epilepsy was 3.9 indicating that people with epilepsy are three to four times more likely to die prematurely than those in the general Chinese population. The risk in young people with epilepsy aged 15–29 years in China is particularly high.

Keywords

Standardize Mortality Ratio Premature Mortality Verbal Autopsy Proportional Mortality Rate International League Against Epilepsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:

AED

anti-epileptic drug

CFR

 case fatality rate

DALY

disability adjusted life year

EMPHL

epilepsy management at primary health level

GBD

global burden of disease

GCAE

global campaign against epilepsy

IBE

International Bureau for Epilepsy

ICBERG

International community-based epilepsy research group

ILAE

International League Against Epilepsy

PMR

 proportional mortality rate

PRC

People’s Republic of China

SMR

standardized mortality ratio

WHO

World Health Organization

YLD

years lived with disability

YLL

years of life lost

References

  1. Cockerell OC, Johnson AL, Sander JW, Hart YM, Goodridge DM, Shorvon SD. (1994). Lancet. 344: 918–921.PubMedCrossRefGoogle Scholar
  2. Ding D, Hong Z, Wang WZ, Wu JZ, de Boer HM, Prilipko L, Sander JW. (2006). Epilepsia. 47: 2032–2037.PubMedCrossRefGoogle Scholar
  3. Ding D, Lu GY, Huang MS, Zhou B, Hou GQ, Zeng J, Jin MH, Zhu GX, Wang JY, Fu JH, Meng HJ, Zhao QH, Hong Z. (2004). Chin J Neurosci. 12: 122–124 (Chinese).Google Scholar
  4. Ding D, Wang WZ, Wu JZ, Ma GY, Dai XY, Yang B, Wang TP, Yuan CL, Hong Z, de Boer HM, Prilipko L, Sander JW. (2006). Lancet Neurol. 5: 823–827.PubMedCrossRefGoogle Scholar
  5. Gaitatzis A, Sander JW. (2004). Epileptic Disord. 6: 3–13.PubMedGoogle Scholar
  6. GBD 2000 (2000). Available from: URL: http://www3.who.int/whosis Accessed 2004.
  7. Kale R. (1997). BMJ. 315: 2–3.PubMedGoogle Scholar
  8. Kleinman A, Wang WZ, Li SC, Cheng XM, Dai XY, Li KT, Kleinman J. (1995). Soc Sci Med. 40: 1319–1330.PubMedCrossRefGoogle Scholar
  9. Li SC. (1989). Chin J Nerv Ment Dis. 22: 144 (Chinese).Google Scholar
  10. Meinardi H, Scott RA, Reis R, Sander JW. (2001). Epilepsia. 42: 136–149.PubMedCrossRefGoogle Scholar
  11. Murray CJL, Lopez AD. (1996). Global Burden of Disease and Injury Series. World Health Organization, Geneva.Google Scholar
  12. Scott RA, Lhatoo SD, Sander JW. (2001). Bull World Health Organ. 79: 344–351.PubMedGoogle Scholar
  13. Wang WZ, Wu JZ, Wang DS, Chen GS, Wang TP, Yuan CL, Yang B, Zhao DH. (2002). Natl Med J China. 82: 449–452 (Chinese).Google Scholar
  14. Wang WZ, Wu JZ, Wang DS, Dai XY, Yang B, Wang TP, Yuan CL, Scott RA, Prilipko L, de Boer HM, Sander JW. (2003). Neurology. 60: 1544–1545.PubMedGoogle Scholar
  15. World Health Organization. (2000). The Global Campaign Against Epilepsy – Out of the Shadows. WHO, Geneva.Google Scholar

Copyright information

© Springer Science+Business Media LLC 2010

Authors and Affiliations

  • D. Ding
    • 1
  • W. Z. Wang
    • 1
  • Z. Hong
    • 1
  1. 1.Department of Biostatistics and EpidemiologyInstitute of Neurology, Fudan University, WHO Collaborating Center for Research and Training in NeurosciencesShanghaiChina>

Personalised recommendations