Handbook of Disease Burdens and Quality of Life Measures pp 1281-1296 | Cite as
Cost-Effectiveness of a Dengue Vaccine in Southeast Asia and Panama: Preliminary Estimates
To ascertain the economic feasibility of a pediatric tetravalent dengue vaccine, we developed and calibrated a cost-effectiveness model of vaccinating children at 15 months in Southeast Asia and Panama using a societal perspective. We assumed that full immunization would require two doses. In Southeast Asia, the gross cost per vaccinee would be US $8.28. Due to projected savings in dengue treatment, the net cost per capita would be 89% below the gross cost. The cost per disability adjusted life year (DALY) saved by a pediatric vaccine would be $50, making the potential vaccine highly cost-effective. In Panama, where we assumed a higher price per dose ($5), the gross cost per vaccinee would be $19.70 for infants and $26.70 in a catch up program for adults. As projected treatment costs are higher, however, averaging $154.27 when discounted to the time of vaccination, the estimated cost offsets would be 178% of vaccination costs for infants and 138% for adults. Thus the dengue vaccination appears to be cost saving under our most likely assumptions. Many uncertainties remain, however, until more epidemiological and economic data are obtained and vaccine development proceeds further.
KeywordsDengue Fever Dengue Hemorrhagic Fever Dengue Case Vector Control Program Dengue Vaccine
List of Abbreviations:
disability adjusted life years
dengue hemorrhagic fever
diphtheria pertussis tetanus (dose 3)
dengue shock syndrome
Global Alliance for Vaccines and Immunization
gross national income
hepatitis B vaccine
hemophilus influenza B
Pan American Health Organization
- SE Asia
World Health Organization
The preparation of this chapter was supported in part by the endowment of the Schneider Institutes for Health Policy, Brandeis University, Waltham, MA, USA. The authors are indebted to Gladys Guerrero, MD, MPH, and Dennys Rodriguez of the Department of Epidemiological Surveillance of the Panama Ministry of Health for providing epidemiological data from Panama, to Blas Armien, MD, of the Gorgas Memorial Institute, Panama, for assistance with analysis of these data, and to Clare L. Hurley, MM, of Brandeis University for editorial assistance.
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