Disease Burden of Dengue Fever and Dengue Hemorrhagic Fever

  • J. A. Suaya
  • D. S. Shepard
  • Mark E. Beatty
  • J. Farrar
Reference work entry


Dengue is a rapidly growing public health problem in tropical and sub-tropical regions of the world. These countries are less economically developed and collectively have a current population in excess of three billion and characteristically very high population growth. Quantifying the epidemiological and economic burden of dengue is key to formulating policy decisions on research priorities, prevention programs, clinical training for management of the disease, and the introduction of new technologies such as vaccines, vector control, diagnostics or drugs. This paper describes current knowledge and gaps in measuring global dengue burden and suggests a framework for developing research priorities. There are a number of major challenges. These include lack of uniform application of the World Health Organization (WHO) case definition, limited access to or standardization of dengue diagnostic tests, misdiagnosis, lack of systematic reporting of dengue cases to WHO, limited surveillance and reliable reporting systems, and limited public awareness in endemic regions and incidence of infection among travelers. The published literature contains few studies on dengue disease burden and hence a great deal of research and allocation of limited public health resources is done in the absence of reliable evidence to guide these decisions.


West Nile Virus Dengue Fever Dengue Hemorrhagic Fever Dengue Infection Dengue Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:


case-fatality rate


disability adjusted life years


dengue disease burden


dengue fever


dengue hemorrhagic fever


dengue shock syndrome


enzyme-linked immunosorbent assay


European region


immunochromatographic test


polymerase chain reaction


Pediatric Dengue Vaccine Initiative


quality adjusted life years


standard deviation


United States of America


World Health Organization



The scientific paper (Suaya et al., 2007b), which served as a background document for this chapter was supported in part by the Pediatric Dengue Vaccine Initiative (PDVI). The preparation of this chapter was supported by the endowment of the Schneider Institutes for Health Policy, Brandeis University. For comments and assistance, the authors are indebted to Chrisann Newransky, MS, Clare Hurley, MM, Rana Sughayyar, MS, and Binod Sah, MD (Brandeis University, U.S.A.), Lucy Lum, MD (University Malaya, Malaysia), Bill Letson, MD (PDVI, Korea) and Axel Kroeger, MD (Special Programme for Research and Training in Tropical Diseases, (TDR), WHO Switzerland).


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Copyright information

© Springer Science+Business Media LLC 2010

Authors and Affiliations

  • J. A. Suaya
    • 1
  • D. S. Shepard
    • 1
  • Mark E. Beatty
    • 2
  • J. Farrar
    • 3
  1. 1.Schneider Institutes for Health Policy, Heller SchoolBrandeis UniversityMAUSA
  2. 2.Pediatric Dengue Vaccine InitiativeInternational Vaccine InstituteSeoulKorea
  3. 3.Hospital for Tropical DiseasesOxford University’s Clinical Research UnitHo Chi Minh CityVietnam

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