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DALYs and Diarrhea

  • R. Oria
  • R. Pinkerton
  • A A M Lima
  • R. L. Guerrant
Reference work entry

Abstract:

Burden of disease assessments must incorporate both years of life lost and years lost to disability. This is especially important for diseases that have long-term effects in addition to early life mortality. Such is increasingly recognized to be the case for early childhood diarrhea, especially in impoverished areas. Although dramatic improvements have been made in reducing childhood diarrhea mortality, the morbidity (illness) rates persist, and have likely lasting effects on children’s physical and even cognitive development. Hence, even though data are limited, existing evidence suggests that these long-term effects of early childhood diarrhea on child development and thus cause potentially lifelong “disability” may be substantial. Although several approaches have been used to assess these disability and mortality impacts, including “Quality adjusted life years” and “Disability adjusted life years,” the latter (DALYs) have gained widespread use. We review this evidence and provide a range of estimates from published information on the “DALY impact” of early childhood diarrhea.

Keywords

Diarrheal Disease Intestinal Infection Enteric Infection Oral Rehydration Therapy Diarrheal Illness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:

ApoE4

apolipoprotein E4

CAT-1

cationic arginine transporter 1

DALY

disability-adjusted life years

EAEC

enteroaggregative Escherichia coli

ECD

early childhood diarrhea

HAART

highly active antiretroviral therapy

HAZ

height-for-age z scores

HIV

human immunodeficiency virus

HST

Harvard step test

IL-8

interleukin-8

IQ

intelligence quotient

ORNT

oral rehydration and nutrition therapy

ORT

oral rehydration therapy

QALY

quality-adjusted life years

SD

standard deviation

TB

tuberculosis

TONI III

test of nonverbal intelligence, version III

WISC

Wechsler intelligence scale for children

YLD

years lost to disability

YPLL

years of potential life lost

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Copyright information

© Springer Science+Business Media LLC 2010

Authors and Affiliations

  • R. Oria
    • 1
  • R. Pinkerton
    • 1
  • A A M Lima
    • 1
  • R. L. Guerrant
    • 1
  1. 1.Centers for Global Health, University of Virginia, CharlottesvilleVirginia and Federal University of CearáFortalezaBrazil

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