Hemoglobin Fluctuations

Reference work entry


Hemoglobin Cycling


Patients under poly-transfusion or treated with erythropoietin-stimulating agents may experience a sort of recurrent Hb “cycling” and these recurrent “down-up-down” Hb excursions may increase fatigue and, contemporarily, lower QOL. Although the immediate effect of blood transfusion is crucial, the resulting increase in Hb levels is transient with return to baseline within a relatively short time. Repeated RBC transfusions are associated with highly variable and unstable Hb concentrations and the fluctuating hematocrit may trigger distinct physiologic compensatory mechanisms, such as an increase in cardiac output.


Public Health Cardiac Output Blood Transfusion Social Policy Compensatory Mechanism 
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© Springer Science+Business Media LLC 2010

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