Disability-Adjusted Life Years, Years of Life Lived with Disability, and Years of Life Lost in Stroke: Italian Perspectives

  • S. Mariotti
Reference work entry


This chapter evaluates the impact of  stroke in Italy in 1999, expressed in terms of disability adjusted life years ( DALYs) using mostly the methods developed by WHO in the Global Burden of Disease (GBD) Study. For mortality, the official mortality data for Italy from ISTAT (Italian National Statistical Institute) was used. For disability, the data on first-ever stroke incidence (FES), remission rate and case fatality derived from the health information system and a research on post-FES disability of the Friuli Venezia-Giulia (FVG) region and similar data from the Tuscany region and from the province of Verona in the Veneto region were used and pooled.

Both the mortality and disability aspects of the impact of stroke are taken into account and  YLLs (years of life lost) and  YLDs (years of life lived with disability) respectively are calculated and then summed to obtain the DALYs. To calculate the YLDs, several epidemiological quantities are estimated by sex and age class and for each of the three areas considered in the study. A mean of the pooled data was used to extrapolate the results to the whole Italy.

About 258,000 YLLs and 153,000 YLDs due to FES were estimated in 1999 for Italy. The results in terms of YLLs, YLDs and DALYs were compared with other studies for which detailed results were available, relative to populations with similar characteristics of development: YLD rates per 100,000 people were similar in Italy to the values obtained in the US BOD study both for men (228 vs. 244) and women (308 vs. 301), but values considerably lower were obtained in the Australian BOD study (175 for men and 118 for women). In terms of DALYs rates per 100,000 people, Italy (723) is more similar to the EURO-A group (the European area including Italy) of the GBD study (671) than to the US (569) or Australia (435), because YLLs in Italy are higher than in those other areas.


Cerebrovascular Disease Stroke Survivor Functional Independence Measure Stroke Incidence Disability Weight 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:


Burden of Disease


Disability Adjusted Life Years


Global Burden of Disease


(a group of 26 economically developed European countries)


First-Ever Stroke


MONItoring of trends and determinants in CArdiovascular disease


International Classification of Diseases


Italian National Statistical Institute


Transient Ischemic Attack


World Health Organization


Friuli Venezia-Giulia


Years of life Lived with Disability


Years of Life Lost



This study was made possible by two grants from the Italian Ministry of Health. The author acknowledges also the important contributions of ideas and work by Dr. Antonella Franzo, Dr. Carlo Francescutti, Dr. Giorgio Simon and Dr. Rossella Di Bidino, co-authors together with Dr. Sergio Mariotti of other papers treating similar subjects.


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  • S. Mariotti

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