The Total Illness Burden Index

  • S. Greenfield
  • J. Billimek
  • S. H. Kaplan


The Total Illness Burden Index is a comprehensive summary measure of case mix or  severity of illness that aggregates all of the patients’ conditions, problems, and diseases, weighting them by their severity. The TIBI offers advantages over other methods of case mix measurement because it (1) is based on clinical information beyond the simple presence or absence of specific diagnoses, (2) is scored using a psychometric approach that avoids reliance on any single variable, (3) predicts health related quality of life and mortality events five or more years in the future, (4) is feasible, utilizing patient report over administrative data while requiring less than 15 minutes to complete, and (5) can be adapted based on the clinical context to assess  comorbidity with respect to a selected index condition, or to assess total morbidity from all of the patient’s conditions.

These features allow the measure to be applied in clinical settings among patients facing real-time treatment decisions and for risk adjustment in research on a wide range of medical outcomes.


Prostate Cancer Index Condition Severity Level Index Disease Dimension Score 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:


analysis of variance


Acute Physiology and Chronic Health Evaluation II




health-related quality of life


Medical Outcomes Study Short Form, a measure of health-related quality of life


Total Illness Burden Index


Prostate cancer version of the Total Illness Burden Index


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Copyright information

© Springer Science+Business Media LLC 2010

Authors and Affiliations

  • S. Greenfield
  • J. Billimek
  • S. H. Kaplan

There are no affiliations available

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