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The Burden of Neglected Diseases in Developing Countries

  • A. Boutayeb
Reference work entry

Abstract:

Although with low mortality rates, neglected diseases are causing severe and permanent disabilities and deformities affecting approximately 1 billion people in the world, yielding millions of  Disability Adjusted Life Years. Unfortunately, despite scientific and technological advances realized during the last century and the evidence of possible research output in the biomedical field, a large population living in developing countries, do not have access to adequate affordable treatment against infectious diseases. The reasons why the so-called neglected diseases have been given very little attention are local, national and international. First of all, these diseases affect almost exclusively extremely poor populations living in remote areas beyond the reach of health services. Secondly, they occur in developing countries where few governments are putting science, technology, and innovation at the centre of their strategies and, in the meantime, war and conflicts are financed at the expense of health services. Thirdly, little (or no) research is currently dedicated to the most neglected diseases because they offer negligible marketable and profitable issues, getting less than 10% of the global spending on health research in spite of being among diseases or conditions that account for 90% of the global disease burden. New initiatives are needed and coordination for a better efficiency should strengthen the existing projects such as  Drug for Neglected Diseases Initiative, Global Alliance for Vaccines and Immunization, The  Human Hookworm Vaccine initiative and the  Foundation for Innovative New Diagnostics.

Keywords

Visceral Leishmaniasis Lymphatic Filariasis Dengue Hemorrhagic Fever Buruli Ulcer Dengue Shock Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:

AIDS

acquired immune defense system

DALY

disability adjusted life years

DF

dengue fever

DHF

dengue hemorrhagic fever

DNDi

drug for neglected diseases initiative

DSS

dengue shock syndrome

EU

European union

FIND

foundation for innovative new diagnostics

FL

filariasis lymphatic

GAVI

global alliance for vaccines and immunization

HHVI

human hookworm vaccine initiative

HIV

human immunodeficiency virus

MDG

millennium development goals

ND

neglected disease

OCDE

organization for economic cooperation and development

OCP

 Onchocerciasis Control Program

UNDP

United Nations Development Program

USAID

United States Agency for Development

VL

visceral leishmaniasis

WHO

World Health Organization

YLD

years lived with disability

YLL

years of life lost

Notes

Acknowledgments

This work is partially funded by the Program Global de Recherche of the university Mohamed Ier.

References

  1. Bartram J, Lewis K, Lenton R, Wright A. (2005). Lancet. 365: 810–812.PubMedGoogle Scholar
  2. Boutayeb A. (2006). Trans R Soc Trop Med Hyg. 100: 191–199.PubMedCrossRefGoogle Scholar
  3. Boutayeb A. (2007). Developing countries and neglected diseases: Challenges and perspectives. Int J Equity Health. doi: 10.1186/1475–9276–6–20.Google Scholar
  4. Derouich M, Boutayeb A. (2006). Appl Math Comput. 177: 528–544.CrossRefGoogle Scholar
  5. European Parliament (EP). (2005). Report on Major and Neglected Diseases in Developing Countries. http://www.europarl.europa.eu. Cited 20 Jan 2008.
  6. Franco-Paredes C, Jones D, Rodrigues-Morales AJ, Santos-Preciado JI. (2007). BMC Public Health. 7: 11.PubMedCrossRefGoogle Scholar
  7. Holveck JC, Ehrenberg JP, Ault SK, Rojas R, Vasquez J, Cerquiera MT, Ippolito-Shepherd J, Genovese MA, Periago MR. (2007). BMC Public Health. 7: 6.PubMedCrossRefGoogle Scholar
  8. Mashelkar RA. (2005). Innov Strat Today. 1: 16–32.Google Scholar
  9. Mathers CD, Ezzati M, Lopez AD. (2007). PLOS Negl Trop Dis. 1: e114.PubMedCrossRefGoogle Scholar
  10. Mèdecins Sans Frontières (MSF). (2007). Report on Drugs for Neglected Diseases. [http://www.accessmed-msf.org/dnd/dndi.asp]. Accessed June 18, 2007.
  11. Molyneux DH. (2004). Lancet. 364: 380–383.PubMedCrossRefGoogle Scholar
  12. Molyneux DH, Hotez PJ, Fenwick A. (2005). PLOS Med. 2: e336.PubMedCrossRefGoogle Scholar
  13. Morel CM. (2003). EMBO Rep. 4: S35–S38.PubMedCrossRefGoogle Scholar
  14. Morel C, Broun D, Dangi A, Elias C, Gardener C, Gupta RK, Haycock J, Heher T, Hoetz P, Kettler H, Keusch G, Krattiger A, Kreutz F, Lee K, Mahoney R, Mashelkar RA, Min H, Matlin S, Mzimba M, Oehler J, Ridley R, Senanayake P, Thorsteinsdottir H, Singer PA, Yun M. (2005). Innov Strat Today. 1: 1–15.Google Scholar
  15. Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B. (2007). Lancet. 307: 851–858.CrossRefGoogle Scholar
  16. Perera M, Witehead M, Molyneux D, Weerasooriya M, Gunatilleke G. (2007). PLOS Negl Trop Dis. 1: e128.PubMedCrossRefGoogle Scholar
  17. Saxena S, Thornicroft G, Whiteford H. (2007). Lancet. 370: 878–889.PubMedCrossRefGoogle Scholar
  18. Thornicroft G. (2007). Lancet. 370: 807–808.PubMedCrossRefGoogle Scholar
  19. Trouiller P, Olliaro P, Torreele E, Orbinski J, Laing R, Ford N. (2002). Lancet. 359: 2188–2194.PubMedCrossRefGoogle Scholar
  20. World Health Organization. (2003a). Global Defence Against the Infectious Diseases Threat. World Health Organization, Geneva.Google Scholar
  21. WHO. (2002). World Health Organization Annual Report. http://www.who.int/whr/2002/en. Cited 20 Dec 2007.
  22. WHO. (2003b). World Health Organization annual Report. http://www.who.int/whr/2003/en. Cited 20 Jan 2008.
  23. WHO. (2004). World Health Organization annual Report. http://www.who.int/whr/2004/en. Cited 20 Jan 2008.

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© Springer Science+Business Media LLC 2010

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  • A. Boutayeb

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