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Quality of Life in Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy: Chinese Perspectives

  • J. R. Gu
  • Z. T. Liao
  • Z. M. Lin
  • R. Srirajaskanthan
Reference work entry

Abstract:

Ankylosing spondylitis and undifferentiated spondyloarthritis are the most commonly recognized clinical subtypes of spondyloarthropathies. The major morbidities of both diseases are functional disability and decrease in the quality of life. The most widely used sets of criteria for diagnosing spondyloarthritis are the European Spondyloarthropathy Study Group criteria and  Amor criteria. Validation studies of both sets in Chinese patients with spondyloarthritis showed a high sensitivity and specificity. However, a new diagnostic algorithm needs to be developed to identify patients at an early stage of disease. Currently different kinds of instruments have been tested to evaluate the quality of life in patients with ankylosing spondylitis from different populations. A specific ankylosing spondylitis quality of life questionnaire has recently been developed recently and validated in a Chinese population. When applying it in a clinical trial regarding the management of ankylosing spondylitis patients with biologic agents, the results suggest that ankylosing spondylitis quality of life questionnaire, activity of the disease (the Bath Ankylosing Spondylitis Activity Index) and metrology (the Bath Ankylosing Spondylitis Metrology Index) are the important parameters for assessing physical function in ankylosing spondylitis. In addition, following therapy the improvement identified using the ankylosing spondylitis quality of life questionnaire significantly correlated with findings identified with other questionnaires of disease activity and function such as the Bath Ankylosing Spondylitis Activity Index and the Bath Ankylosing Spondylitis Functional Index. However, the exact role of biologic agents in management of ankylosing spondylitis or other spondyloarthritis in Chinese populations needs further evaluation.

Keywords

Ankylose Spondylitis Anterior Uveitis Human Leucocyte Antigen Bath Ankylose Spondylitis Functional Index Bath Ankylose Spondylitis Metrology Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:

AS

ankylosing spondylitis

ASQOL

ankylosing spondylitis quality of life questionnaire

BASDAI

the bath ankylosing spondylitis activity index

BASFI

the bath ankylosing spondylitis functional index

BAS-G

the bath ankylosing spondylitis global assessment

BASMI

the bath ankylosing spondylitis metrology index

COPCORD

community orientated program for the control of rheumatic diseases

CRP

C-reactive protein

DFI

Dougados functional index

ESR

erythrocyte sedimentation rate

ESSG

European spondyloarthropathy study group

HLA-B27

human leucocyte antigen B27

Hs-CRP

high sensitivity C-reactive protein

MRI

magnetic resonance imaging

NSAIDs

nonsteroid anti-inflammatory drugs

QOL

quality of life

SF-36

short form-36

SpA

spondyloarthritis

USpA

undifferentiated spondyloarthritis

VAS

visual assessment scale

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Copyright information

© Springer Science+Business Media LLC 2010

Authors and Affiliations

  • J. R. Gu
    • 1
  • Z. T. Liao
    • 1
  • Z. M. Lin
    • 1
  • R. Srirajaskanthan
    • 2
  1. 1.Division of RheumatologyThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouPeople’s Republic of China
  2. 2.Department of nutrition and dieteticsKings CollegeNashvilleLondon

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