Quality of Life in Systemic Sclerosis

Mouthon, L.; Rannou, F.; Berezné, A.; Poiraudeau, S.

doi:10.1007/978-0-387-78665-0_222

L. Mouthon³,
F. Rannou⁴,
A. Berezné³ &
…
S. Poiraudeau⁴

149 Accesses

Abstract:

Systemic sclerosis (SSc) is a connective-tissue disease characterized by excessive collagen deposition and by vascular hyper-reactivity and obliterative microvascular phenomena. In addition to diminishing life expectancy, SSc is responsible for skin, tendon, joint, and vessel damage, which leads to disability, handicap, and worsening of quality of life.

Health related quality of life can be measured in systemic sclerosis patients by using the Medical Outcomes Study 36-Item Short-Form Health Survey and/or the World Health Organization Disability Assessment Schedule II. Health related quality of life has been reported to be compromised in patients with systemic sclerosis.

Not surprisingly, health related quality of life, when measured using the 36-Item Short-Form Health Survey, has been reported to be compromised in patients with systemic sclerosis, and the use of the physical component score of the 36-Item Short-Form Health Survey has been shown to discriminate between patients with limited cutaneous SSc and those with diffuse systemic sclerosis. However, the relevance of using the two aggregate scores, physical component score and the mental component score has not been demonstrated in SSc.

The Health Organization Disability Assessment Schedule II is a multidimensional instrument which has good ability to discriminate between subsets of systemic sclerosis (Classification of Systemic Sclerosis) patients with less severe disease compared with those with more severe disease. In these patients, significant predictors of the Health Organization Disability Assessment Schedule II are skin scores, shortness of breath, number of gastrointestinal problems, fatigue, pain, and depression.

In systemic sclerosis patients health related quality of life is significantly impaired as compared with the healthy population as assessed by the 36-Item Short-Form Health Survey and/or the Health Organization Disability Assessment Schedule II. Whether one of the two or both of these tests are necessary remains to be determined.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 3,000.00; Price excludes VAT (USA)

Hardcover Book: USD 549.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

BDI:: baseline dyspnea index
CHFS:: Cochin hand function scale
HAD:: hospital anxiety and depression
HAQ:: Health assessment questionnaire
HRQOL:: Health related quality of life
ICF:: International Classification of Functioning, Disability and Health
MACTAR:: McMaster-Toronto Arthritis Patient Preference Disability Questionnaire
MCS:: mental component score
MHISS:: Mouth Handicap In Systemic Sclerosis
MOS:: Medical Outcomes Study
PCS:: physical component score
SD:: standard deviation
SF-36:: 36-Item Short-Form Health Survey
sHAQ:: scleroderma HAQ
SSc:: systemic sclerosis
lSSc:: limited SSc
lcSSc:: limited cutaneous SSc
dSSc:: diffuse SSc
VAS:: visual analog scale
WHODAS II:: World Health Organization Disability Assessment Schedule II

References

Tamby MC, Chanseaud Y, Guillevin L, et al. (2003). Autoimmun Rev. 2: 152–157.
Article PubMed CAS Google Scholar
LeRoy EC, Medsger TA, Jr. (2001). J Rheumatol. 28: 1573–1576.
PubMed CAS Google Scholar
Masi AT. (1988). J Rheumatol. 15: 894–898.
PubMed CAS Google Scholar
Hachulla E, Gressin V, Guillevin L, et al. (2005). Arthritis Rheum. 52: 3792–3800.
Article PubMed Google Scholar
Steen VD, Medsger TA Jr. (2000). Arthritis Rheum. 43: 2437–2444.
Article PubMed CAS Google Scholar
Steen VD, Medsger TA. (2000). Ann Intern Med. 133: 600–603.
PubMed CAS Google Scholar
Bouros D, Wells AU, Nicholson AG, et al. (2002). Am J Respir Crit Care Med. 165: 1581–1586.
Article PubMed Google Scholar
Poole JL, Steen VD. (1991). Arthritis Care Res. 4: 27–31.
Article PubMed CAS Google Scholar
Guyatt GH, Feeny DH, Patrick DL. (1993). Ann Intern Med. 118: 622–629.
PubMed CAS Google Scholar
O'Reilly S, Dogherty M. (2003). Signs, symptoms and laboratory tests. K. Brandt, M. Dogherty, and L. Lohmander, (Ed). Osteoarthritis. 2nd Edn, In:Oxford University Press: New-York. p. 197–210.
Google Scholar
Xie F, Li SC, Fong KY, et al. (2006). Osteoarthritis Cartilage. 14: 224–230.
Article PubMed CAS Google Scholar
Ware J, Snow K, Kosinski M, et al. (1993). SF-36 Health Survey: manual and interpretation guide. The Health Institute, New England Medical Center.Boston:
Google Scholar
Kosinski M, Keller SD, Hatoum HT, et al. (1999). Med Care. 37: MS10–MS22.
Article PubMed CAS Google Scholar
Patrick DL, Deyo RA. (1989). Med Care. 27: S217–S232.
Article PubMed CAS Google Scholar
Ware JE Jr., Sherbourne CD. (1992). Med Care. 30: 473–483.
Article PubMed Google Scholar
Kosinski M, Keller SD, Ware JE Jr., et al. (1999). Med Care. 37: MS23–MS39.
Article PubMed CAS Google Scholar
Del Rosso A, Boldrini M, D'Agostino D, et al. (2004). Arthritis Rheum. 51: 475–481.
Article PubMed Google Scholar
Danieli E, Airo P, Bettoni L, et al. (2005). Clin Rheumatol. 24: 48–54.
Article PubMed Google Scholar
Georges C, Chassany O, Mouthon L, et al. (2004). Rev Med Interne. 25: 16–21.
Article PubMed CAS Google Scholar
Khanna D, Furst DE, Clements PJ, et al. (2005). J Rheumatol. 32: 832–840.
PubMed Google Scholar
Khanna D, Clements PJ, Furst DE, et al. (2005). Arthritis Rheum. 52: 592–600.
Article PubMed Google Scholar
Merkel PA, Clements PJ, Reveille JD, et al. (2003). Report from OMERACT 6. J Rheumatol. 30: 1630–1647.
Google Scholar
Khanna D, Ahmed M, Furst DE, et al. (2007). Arthritis Rheum. 57: 86–93.
Article PubMed Google Scholar
Rannou F, Poiraudeau S, Berezné A, et al. (2007). Arthritis Rheum. 57(1): 94–102. [Epub ahead of print].
Article PubMed Google Scholar
Bowling A, Bond M, Jenkinson C, et al. (1999). J Public Health Med. 21: 255–270.
Article PubMed CAS Google Scholar
McHorney CA, Ware JE Jr., Raczek AE. (1993). Med Care. 31: 247–263.
Article PubMed CAS Google Scholar
International Classification of Functioning, Disability, and Health., in World Health Organization, n. ed., Editor. 2001: Geneva.
Google Scholar
van Tubergen A, Landewe R, Heuft-Dorenbosch L, et al. (2003). Ann Rheum Dis. 62: 140–145.
Article PubMed CAS Google Scholar
Poesl M (2004). in URL: http://edoc.ub.uni-muenchen.de/archive/00002533/02/Poesl_Miriam.pdf.
Chwastiak LA, Von Korff M. (2003). J Clin Epidemiol. 56: 507–514.
Article PubMed Google Scholar
Hudson M, Steele R, Taillefer S, et al. (2008). Arthritis Rheum. 59: 270–278.
Article PubMed Google Scholar
Hudson M, Thombs BD, Steele R, et al. (2008). Arthritis Rheum. 59: 279–284.
Article PubMed Google Scholar
Khanna D, Yan X, Tashkin DP, et al. (2007). Arthritis Rheum. 56: 1676–1684.
Article PubMed CAS Google Scholar
Kaplan RM, Atkins CJ, Timms R. (1984). J Chronic Dis. 37: 85–95.
Article PubMed CAS Google Scholar
Jones PW, Quirk FH, Baveystock CM, et al. (1992). Am Rev Respir Dis. 145: 1321–1327.
PubMed CAS Google Scholar
Jones PW, Quirk FH, Baveystock CM. (1991). Respir Med. 85(B): 25–31; discussion 33–7.
Article PubMed Google Scholar
Nishiyama O, Taniguchi H, Kondoh Y, et al. (2005). Respir Med. 99: 408–414.
Article PubMed CAS Google Scholar
Chang JA, Curtis JR, Patrick DL, et al. (1999). Chest. 116: 1175–1182.
Article PubMed CAS Google Scholar
Tzanakis N, Samiou M, Lambiri I, et al. (2005). Eur J Intern Med. 16: 105–112.
Article PubMed Google Scholar
Beretta L, Santaniello A, Lemos A, Masciocchi M, Scorza R. (2007). Rheumatology (Oxford) 46 2: 296–301.
Google Scholar
Poole JL, William CA, Bloch DA, et al. (1995). Arthritis Care Res. 8: 189–193.
Article PubMed CAS Google Scholar
Merkel PA, Herlyn K, Martin RW, et al. (2002). Arthritis Rheum. 46: 2410–2420.
Article PubMed Google Scholar
Steen VD, Medsger TA. (1997). Arthritis Rheum. 40: 1984–1991.
Article PubMed CAS Google Scholar
Clements PJ, Wong WK, Hurwitz EL, et al. (2001). Arthritis Rheum. 44: 653–61.
Article PubMed CAS Google Scholar
Brower LM, Poole JL. (2004). Arthritis Rheum. 51: 805–809.
Article PubMed Google Scholar
Mouthon L, Rannou F, Berezne A, et al. (2007). Ann Rheum Dis. 66: 1651–1655.
Article PubMed CAS Google Scholar
Tugwell P, Bombardier C, Buchanan WW, et al. J Rheumatol. 14: 446–451.
Google Scholar
Hewlett S, Smith AP, Kirwan JR. (2001). Ann Rheum Dis. 60: 928–933.
Article PubMed CAS Google Scholar
Verhoeven AC, Boers M, van der Liden S. (2000). J Rheumatol. 27: 2801–2809.
PubMed CAS Google Scholar
Mouthon L, Rannou F, Berezne A, et al. (2008). Arthritis Rheum. 59: 968–973.
Article PubMed Google Scholar

Download references

Acknowledgements

We thank the Association des sclérodermiques de France for its support.

Author information

Authors and Affiliations

Department of Internal Medicine, Paris Descartes University, Reference Center for Necrotizing Vasculitides and Systemic Sclerosis, Cochin Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
L. Mouthon & A. Berezné
Department of Rehabilitation, Paris Descartes University, Cochin Hospital, AP-HP, INSERM Institut Féderatif de Recherche sur le Handicap (IFR 25), Nashville, Paris
F. Rannou & S. Poiraudeau

Authors

L. Mouthon
View author publications
You can also search for this author in PubMed Google Scholar
F. Rannou
View author publications
You can also search for this author in PubMed Google Scholar
A. Berezné
View author publications
You can also search for this author in PubMed Google Scholar
S. Poiraudeau
View author publications
You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

Dept. Nutrition and Dietetics Nutritional Sciences Research Division School of Biomedical & Health Sciences, King's College London, Franklin‐Wilkins Building 150 Stamford Street, SE1 9NH, London, UK
Victor R. Preedy (Prof.) (Prof.)
Mel and Enid Zuckerman College of Public Health, University of Arizona, Health Science Center 1295 N. Martin, P.O. Box 245155, 85724-5155, Tucson, AZ
Ronald R. Watson (Prof.) (Prof.)

Rights and permissions

Reprints and permissions

Copyright information

About this entry

Cite this entry

Mouthon, L., Rannou, F., Berezné, A., Poiraudeau, S. (2010). Quality of Life in Systemic Sclerosis. In: Preedy, V.R., Watson, R.R. (eds) Handbook of Disease Burdens and Quality of Life Measures. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78665-0_222

Download citation

DOI: https://doi.org/10.1007/978-0-387-78665-0_222
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-78664-3
Online ISBN: 978-0-387-78665-0
eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics