Handbook of Disease Burdens and Quality of Life Measures pp 3769-3783 | Cite as
Quality of Life in Patients Affected by Multiple Sclerosis: A Systematic Review
Quality of Life (QOL) instruments are increasingly being used in multinational research and clinical practice.
More than 20 years of research have led a consensus on the definition of QOL as a multidimensional concept that detects at least four health-related domains (physical, social, psychological/emotional functions, and financial). These domains, not directly linked to disability or impairment, are considered highly important by the patients. These assertions are particularly appropriate in patients affected by multiple sclerosis (MS), who are less concerned than their clinicians about physical disability in their illness.
A large number of studies have demonstrated that patients with MS have poorer QOL than that of the general population.
Predictors of QOL in MS are distinguished between clinical and socio-demographic variables. Clinical predictors include the phenotype, disease duration, disability, depression, fatigue, cognitive impairment, bladder dysfunction, sexual and bowel disturbances, pain, and sleep disturbances. Age, gender, employment status, and education level (employment status and education in MS people) have been identified as socio-demographic variables.
In this review, we have tried to target attention on the different issues of QOL in MS –definition, measurement, relationship with the disease, and effects of treatment. As physicians we are firmly convinced that it is useful to incorporate QOL measures in clinical practice.
KeywordsMultiple Sclerosis Multiple Sclerosis Patient Expand Disability Status Scale Patient Generation Index Multiple Sclerosis Subject
List of Abbreviations:
disease modifying drugs
health-related quality of life
multiattribute utility scale
major depressive disorders
- MSQOL 54
multiple sclerosis quality of life-54 instrument
primary-progressive multiple sclerosis
quality of life index
quality of life
relapsing–remitting multiple sclerosis
schedule for the evaluation of individual QOL – direct weighting
- SF 36
short form health survey questionnaire
secondary-progressive multiple sclerosis
World Health Organization
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