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Quality of Life in Patients Affected by Multiple Sclerosis: A Systematic Review

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Handbook of Disease Burdens and Quality of Life Measures

Abstract:

Quality of Life (QOL) instruments are increasingly being used in multinational research and clinical practice.

More than 20 years of research have led a consensus on the definition of QOL as a multidimensional concept that detects at least four health-related domains (physical, social, psychological/emotional functions, and financial). These domains, not directly linked to disability or impairment, are considered highly important by the patients. These assertions are particularly appropriate in patients affected by multiple sclerosis (MS), who are less concerned than their clinicians about physical disability in their illness.

A large number of studies have demonstrated that patients with MS have poorer QOL than that of the general population.

Predictors of QOL in MS are distinguished between clinical and socio-demographic variables. Clinical predictors include the phenotype, disease duration, disability, depression, fatigue, cognitive impairment, bladder dysfunction, sexual and bowel disturbances, pain, and sleep disturbances. Age, gender, employment status, and education level (employment status and education in MS people) have been identified as socio-demographic variables.

In this review, we have tried to target attention on the different issues of QOL in MS –definition, measurement, relationship with the disease, and effects of treatment. As physicians we are firmly convinced that it is useful to incorporate QOL measures in clinical practice.

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Abbreviations

DMDs:

disease modifying drugs

EDSS:

expanded disability status scale

HRQOL:

health-related quality of life

MAUS:

multiattribute utility scale

MDD:

major depressive disorders

MS:

multiple sclerosis

MSQOL 54:

multiple sclerosis quality of life-54 instrument

PPMS:

primary-progressive multiple sclerosis

QALYs:

quality-adjusted life-years

QLI:

quality of life index

QOL:

quality of life

RRMS:

relapsing–remitting multiple sclerosis

SEIDWQOL:

schedule for the evaluation of individual QOL – direct weighting

SF 36:

short form health survey questionnaire

SPMS:

secondary-progressive multiple sclerosis

WHO:

World Health Organization

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Authors and Affiliations

  1. Department of Neurology, Multiple Sclerosis Centre- University of Catania, Nashville, Italy

    F. Patti & A. Pappalardo

Authors
  1. F. Patti
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  2. A. Pappalardo
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Editor information

Editors and Affiliations

  1. Dept. Nutrition and Dietetics Nutritional Sciences Research Division School of Biomedical & Health Sciences, King's College London, Franklin‐Wilkins Building 150 Stamford Street, SE1 9NH, London, UK

    Victor R. Preedy (Prof.) (Prof.)

  2. Mel and Enid Zuckerman College of Public Health, University of Arizona, Health Science Center 1295 N. Martin, P.O. Box 245155, 85724-5155, Tucson, AZ

    Ronald R. Watson (Prof.) (Prof.)

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Patti, F., Pappalardo, A. (2010). Quality of Life in Patients Affected by Multiple Sclerosis: A Systematic Review. In: Preedy, V.R., Watson, R.R. (eds) Handbook of Disease Burdens and Quality of Life Measures. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78665-0_218

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  • DOI: https://doi.org/10.1007/978-0-387-78665-0_218

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-78664-3

  • Online ISBN: 978-0-387-78665-0

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