Handbook of Disease Burdens and Quality of Life Measures pp 3643-3656 | Cite as
Quality of Life and Neuropsychological Symptoms in Primary Hyperparathyroidism
Primary hyperparathyroidism (pHPT) is mostly caused by a single-gland parathyroid adenoma. Clinical manifestations of pHPT are osteitits fibrosa cystica, nephrolithiasis and peptic ulcer disease. In a considerable number of patients a decreased quality of life and neuropsychological symptoms as such fatigue, weakness, mood swings, depression, and anxiety are suspected.
The aim of this chapter is to provide a rigorous and critical review of studies evaluating health-related quality of life and neuropsychological symptoms in patients with pHPT before and after parathyroid surgery. Preoperative health-related quality of life was found to be markedly reduced in patients with pHPT in 7 of 8 studies. After parathyroidectomy, 8 of 12 studies described significantly improved physical symptoms and 11 of 12 studies found improved mental symptoms using the SF-36 ( Medical Outcomes Short Form Health Survey-36). Neuropsychological symptoms were measured with various instruments. Preoperatively, 5 of 9 studies showed higher scores for psychological symptoms in patients with pHPT than in controls. Postoperatively, 4 of 9 studies found a decrease in psychological symptoms after parathyroidectomy.
Health-related quality of life is reduced in pHPT and neuropsychological symptoms are found in a considerable number of patients. Parathyroid surgery is able to improve quality of life in patients with pHPT. Its influence on neuropsychological symptoms should be evaluated in further longitudinal studies.
KeywordsPrimary Hyperparathyroidism Parathyroid Adenoma Parathyroid Carcinoma Mental Component Score Parathyroid Surgery
List of Abbreviations:
familial hypocalciuric hypercalcemia
hopkins symptom checklist
magnetic resonance imaging
medical outcomes short form health survey - 36
single-photon emission computed tomography
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