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Cognitive Function, Mood and Health-Related Quality of Life in Hepatitis C Virus-Infected Individuals

  • Reference work entry
Handbook of Disease Burdens and Quality of Life Measures

Abstract:

People with chronic hepatitis C virus (HCV) infection commonly experience neuropsychological symptoms, including fatigue, depression, difficulty concentrating, and forgetfulness despite early liver disease. Although there has been limited evaluation of the relationship between symptoms and health-related quality of life (HRQOL), chronic HCV infection seems to impair cognitive function and HRQOL even in earlier stages in the absence of severe liver disease. The likelihood of impairment increases with greater severity of liver disease and advanced human immunodeficiency virus (HIV). There is evidence that successful antiviral therapy is associated with improvement in both cognitive function and HRQOL. However, the etiology of cognitive and HRQOL impairment in chronic HCV infection remains unclear. Potential explanations for the impairment include direct and indirect viral effects, inability to disentangle the effects of concomitant comorbid conditions including the effects of coinfection with HIV, drug dependency, psychiatric disease, the psychological impact of HCV diagnosis, or poor health. Further research is required to understand the relationship between HCV-related symptoms and HRQOL and to explore causality of cognitive and HRQOL impairment in chronic HCV infection.

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Abbreviations

HCV:

hepatitis C virus

HRQOL:

health-related quality of life

HIV:

human immunodeficiency virus

MHE:

minimal hepatic encephalopathy

1H MRS:

proton magnetic resonance spectroscopy

EEG:

electroencephalogram

IFN:

interferon

HBV:

hepatitis B

IVDU:

intravenous drug use

ETOH:

alcohol

CHO:

choline

QOL:

quality of life

ALT:

alanine aminotransfers

METH:

methamphetamine

NAA:

N-acetylaspartate

QEEG:

quantitative electroencephalogram

PET:

positron emission tomography

R:

right

L:

left

fMRI:

functional magnetic resonance imaging

PEGASYS:

peginterferon alfa-2a

peg intron:

recombinant interferon alpha, subtype 2b, and polyethylene glycol

IDUs:

injecting drug users

CNS:

central nervous system

PBMCs:

peripheral blood mononuclear cells

CSF:

cerebrospinal fluid

TNF-α:

tumor necrosis factor-alpha

ART:

antiretroviral therapy

AIDS:

acquired immune deficiency syndrome

5-HT:

5-hydroxytryptamine

SF-36:

short form-36 health survey

MCS:

mental component score

PCS:

physical component score

SVR:

sustained virological response

CLDQ:

chronic liver disease questionnaire

References

  • Alberti A, Noventa F, Benvegnu L, Boccato S, Gatta A. (2002). Ann Intern Med. 137: 961–964.

    PubMed  Google Scholar 

  • Alter MJ. (2002). Hepatology. 36: S93–S98.

    PubMed  Google Scholar 

  • Amodio P, De Toni EN, Cavalletto L, Mapelli D, Bernardinello E, Del Piccolo F, Bergamelli C, Costanzo R, Bergamaschi F, Poma SZ, Chemello L, Gatta A, Perini G. (2005). J Affect Disord. 84: 93–98.

    PubMed  CAS  Google Scholar 

  • Arora S, O’Brien C, Zeuzem S, Shiffman ML, Diago M, Tran A, Pockros PJ, Reindollar RW, Gane E, Patel K, Wintfeld N, Green J. (2006). J Gastroenterol Hepatol. 21: 406–412.

    PubMed  CAS  Google Scholar 

  • Bacon BR. (2002). Hepatology. 36: S179–S184.

    PubMed  CAS  Google Scholar 

  • Balfour L, Cooper C, Kowal J, Tasca GA, Silverman A, Kane M, Garber G. (2006). Can J Gastroenterol. 20: 81–86.

    PubMed  Google Scholar 

  • Barkhuizen A, Rosen HR, Wolf S, Flora K, Benner K, Bennett RM. (1999). Am J Gastroenterol. 94: 1355–1360.

    PubMed  CAS  Google Scholar 

  • Barrett S, Goh J, Coughlan B, Ryan E, Stewart S, Cockram A, O’Keane JC, Crowe J. (2001). Gut. 49: 423–430.

    PubMed  CAS  Google Scholar 

  • Bayliss MS, Gandek B, Bungay KM, Sugano D, Hsu MA, Ware JE Jr. (1998). Qual Life Res. 7: 39–55.

    PubMed  CAS  Google Scholar 

  • Bernstein D, Kleinman L, Barker CM, Revicki DA, Green J. (2002). Hepatology. 35: 704–708.

    PubMed  Google Scholar 

  • Bini E, Baskies M, Achkar J, Maslow M. (2001). DDW Conference. NATAP Reports, Atlanta, Georgia, [Abstract].

    Google Scholar 

  • Blei AT. (2004). J Hepatol. 40: 327–330.

    PubMed  Google Scholar 

  • Bonkovsky HL, Snow KK, Malet PF, Back-Madruga C, Fontana RJ, Sterling RK, Kulig CC, Di Bisceglie AM, Morgan TR, Dienstag JL, Ghany MG, Gretch DR. (2007). J Hepatol. 46: 420–431.

    PubMed  Google Scholar 

  • Bonkovsky HL, Woolley JM. (1999). Hepatology. 29: 264–270.

    PubMed  CAS  Google Scholar 

  • Cacoub P, Renou C, Rosenthal E, Cohen P, Loury I, Loustaud-Ratti V, Yamamoto AM, Camproux AC, Hausfater P, Musset L, Veyssier P, Raguin G, Piette JC. (2000). Medicine. 79: 47–56.

    PubMed  CAS  Google Scholar 

  • Capuron L, Pagnoni G, Demetrashvili M, Woolwine BJ, Nemeroff CB, Berns GS, Miller AH. (2005). Biol Psychiatry. 58: 190–196.

    PubMed  CAS  Google Scholar 

  • Carithers RL Jr., Sugano D, Bayliss M. (1996). Dig Dis Sci. 41: 75S–80S.

    PubMed  Google Scholar 

  • Cherner M, Letendre S, Heaton RK, Durelle J, Marquie-Beck J, Gragg B, Grant I. (2005). Neurology. 64: 1343–1347.

    PubMed  CAS  Google Scholar 

  • Clifford DB, Evans SR, Yang Y, Gulick RM. (2005). AIDS. 19(Suppl 3): S64–S71.

    PubMed  Google Scholar 

  • Cordoba J, Flavia M, Jacas C, Sauleda S, Esteban JI, Vargas V, Esteban R, Guardia J. (2003a). J Hepatol. 39: 231–238.

    PubMed  Google Scholar 

  • Cordoba J, Raguer N, Flavia M, Vargas V, Jacas C, Alonso J, Rovira A. (2003b). Hepatology. 38: 1026–1033.

    PubMed  Google Scholar 

  • Coughlan B, Sheehan J, Hickey A, Crowe J. (2002). Br J Health Psychol. 7: 105–116.

    PubMed  Google Scholar 

  • Dalgard O, Egeland A, Skaug K, Vilimas K, Steen T. (2004). Hepatology. 39: 74–80.

    PubMed  Google Scholar 

  • Dan AA, Martin LM, Crone C, Ong JP, Farmer DW, Wise T, Robbins SC, Younossi ZM. (2006). J Hepatol. 44: 491–498.

    PubMed  Google Scholar 

  • Davis GL, Balart LA, Schiff ER, Lindsay K, Bodenheimer HC Jr., Perrillo RP, Carey W, Jacobson IM, Payne J, Dienstag JL, et al. (1994). Clin Ther. 16: 334–343.

    PubMed  CAS  Google Scholar 

  • Davis PE, Liddiard H, McMillan TM. (2002). Drug Alcohol Depend. 67: 105–108.

    PubMed  CAS  Google Scholar 

  • Di Bisceglie AM. (1998). Lancet. 351: 351–355.

    PubMed  CAS  Google Scholar 

  • Dwight MM, Kowdley KV, Russo JE, Ciechanowski PS, Larson AM, Katon WJ. (2000). J Psychosom Res. 49: 311–317.

    PubMed  CAS  Google Scholar 

  • Eyster ME, Fried MW, Di Bisceglie AM, Goedert JJ. (1994). Blood. 84: 1020–1023.

    PubMed  CAS  Google Scholar 

  • Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. (2002). Hepatology. 35: 716–721.

    PubMed  Google Scholar 

  • Fleming CA, Christiansen D, Nunes D, Heeren T, Thornton D, Horsburgh CR Jr., Koziel MJ, Graham C, Craven DE. (2004). Clin Infect Dis. 38: 572–578.

    PubMed  Google Scholar 

  • Flugel A, Bradl M, Kreutzberg GW, Graeber MB. (2001). J Neurosci Res. 66: 74–82.

    PubMed  CAS  Google Scholar 

  • Fontana RJ, Bieliauskas LA, Back-Madruga C, Lindsay KL, Kronfol Z, Lok AS, Padmanabhan L. (2005). J Hepatol. 43: 614–622.

    PubMed  Google Scholar 

  • Fontana RJ, Hussain KB, Schwartz SM, Moyer CA, Su GL, Lok AS. (2002). J Hepatol. 36: 401–407.

    PubMed  Google Scholar 

  • Fontana RJ, Moyer CA, Sonnad S, Lok ASF, Sneed-Pee N, Walsh J, Klein S, Webster S. (2001). Am J Gastroenterol. 96: 170–178.

    PubMed  CAS  Google Scholar 

  • Forton DM, Allsop JM, Cox IJ, Hamilton G, Wesnes K, Thomas HC, Taylor-Robinson SD. (2005). AIDS. 19(Suppl 3): S53–S63.

    PubMed  Google Scholar 

  • Forton DM, Allsop JM, Main J, Foster GR, Thomas HC, Taylor-Robinson SD. (2001). Lancet. 358: 38–39.

    PubMed  CAS  Google Scholar 

  • Forton DM, Karayiannis P, Mahmud N, Taylor-Robinson SD, Thomas HC. (2004a). J Virol. 78: 5170–5183.

    PubMed  CAS  Google Scholar 

  • Forton DM, Taylor-Robinson SD, Thomas HC. (2002a). J Hepatol. 36: 435–438.

    PubMed  Google Scholar 

  • Forton DM, Taylor-Robinson SD, Thomas HC. (2003). J Viral Hepat. 10: 81–86.

    PubMed  CAS  Google Scholar 

  • Forton DM, Taylor-Robinson SD, Thomas HC. (2006). Eur J Gastroenterol Hepatol. 18: 333–338.

    PubMed  Google Scholar 

  • Forton DM, Thomas HC, Murphy CA, Allsop JM, Foster GR, Main J, Wesnes KA, Taylor-Robinson SD. (2002b). Hepatology. 35: 433–439.

    PubMed  Google Scholar 

  • Forton DM, Thomas HC, Taylor-Robinson SD. (2004b). Metab Brain Dis. 19: 383–391.

    PubMed  Google Scholar 

  • Foster GR, Goldin RD, Thomas HC. (1998). Hepatology. 27: 209–212.

    PubMed  CAS  Google Scholar 

  • Gallegos-Orozco JF, Fuentes AP, Gerardo Argueta J, Perez-Pruna C, Hinojosa-Becerril C, Sixtos-Alonso MS, Cruz-Castellanos S, Gutierrez-Reyes G, Olivera-Martinez MA, Gutierrez-Ruiz MC, Kershenobich D. (2003). Arch Med Res. 34: 124–129.

    PubMed  Google Scholar 

  • Gifford SM, O’Brien ML, Bammer G, Banwell C, Stoove M. (2003). J Gastroenterol Hepatol. 18: 841–850.

    PubMed  Google Scholar 

  • Goh J, Coughlan B, Quinn J, O’Keane JC, Crowe J. (1999). Eur J Gastroenterol Hepatol. 11: 833–838.

    PubMed  CAS  Google Scholar 

  • Goulding C, O’Connell P, Murray FE. (2001). Eur J Gastroenterol Hepatol. 13: 507–511.

    PubMed  CAS  Google Scholar 

  • Grant I. (1987). J Consult Clin Psychol. 55: 310–324.

    PubMed  CAS  Google Scholar 

  • Gualtieri CT, Johnson LG, Benedict KB. (2006). J Neuropsychiatry Clin Neurosci. 18: 217–225.

    PubMed  Google Scholar 

  • Hassanein T, Cooksley G, Sulkowski M, Smith C, Marinos G, Lai MY, Pastore G, Trejo-Estrada R, Horta EVA, Wintfeld N, Green J. (2004). J Hepatol. 40: 675–681.

    PubMed  CAS  Google Scholar 

  • Hassanein TI, Hilsabeck RC, Hwang S, Medley K, Ziegler BA. (2001). Hepatology. AB1712 [Abstract].

    Google Scholar 

  • Hauser W, Zimmer C, Schiedermaier P, Grandt D. (2004). Psychosom Med. 66: 954–958.

    PubMed  Google Scholar 

  • Heaton RK, Grant I, Butters N, White DA, Kirson D, Atkinson JH, McCutchan JA, Taylor MJ, Kelly MD, Ellis RJ, et al. (1995). J Int Neuropsychol Soc. 1: 231–251.

    PubMed  CAS  Google Scholar 

  • Hilsabeck RC, Hassanein TI, Carlson MD, Ziegler EA, Perry W. (2003). J Int Neuropsychol Soc. 9: 847–854.

    PubMed  Google Scholar 

  • Hilsabeck RC, Hassanein TI, Ziegler EA, Carlson MD, Perry W. (2005). J Int Neuropsychol Soc. 11: 16–22.

    PubMed  CAS  Google Scholar 

  • Hilsabeck RC, Perry W, Hassanein TI (2002). Hepatology. 35: 440–446.

    PubMed  Google Scholar 

  • Hinkin CH, van Gorp WG, Mandelkern MA, Gee M, Satz P, Holston S, Marcotte TD, Evans G, Paz DH, Ropchan JR. (1995). J Neuropsychol Clin Neurosci. 7: 180–187.

    CAS  Google Scholar 

  • Hoofnagle JH. (1997). Hepatology. 26: 15S–20S.

    PubMed  CAS  Google Scholar 

  • Hui CK, Belaye T, Montegrande K, Wright TL. (2003). J Hepatol. 38: 511–517.

    PubMed  CAS  Google Scholar 

  • Hunt CM, Dominitz JA, Bute BP, Waters B, Blasi U, Williams DM. (1997). Dig Dis Sci. 42: 2482–2486.

    PubMed  CAS  Google Scholar 

  • Hussain KB, Fontana RJ, Moyer CA, Su GL, Sneed-Pee N, Lok AS. (2001). Am J Gastroenterol. 96: 2737–2744.

    PubMed  CAS  Google Scholar 

  • Ingraham LJ, Aiken CB. (1996). Neuropsychology. 10: 120–124.

    Google Scholar 

  • Jamal MM, Soni A, Quinn PG, Wheeler DE, Arora S, Johnston DE. (1999). Hepatology. 30: 1307–1311.

    PubMed  CAS  Google Scholar 

  • Johnson ME, Fisher DG, Fenaughty A, Theno SA. (1998). Am J Gastroenterol. 93: 785–789.

    PubMed  CAS  Google Scholar 

  • Juengling FD, Ebert D, Gut O, Engelbrecht MA, Rasenack J, Nitzsche EU, Bauer J, Lieb K. (2000). Psychopharmacology. 152: 383–389.

    PubMed  CAS  Google Scholar 

  • Kallman J, O’Neil MM, Larive B, Boparai N, Calabrese L, Younossi ZM. (2007). Dig Dis Sci. 52: 2531–2539.

    PubMed  Google Scholar 

  • Kamei S, Oga K. Matsuura M, Tanaka N, Kojima T, Arakawa Y, Matsukawa Y, Mizutani T, Sakai T, Ohkubo H, Matsumura H, Moriyama M, Hirayanagi K. (2005). J Clin Neurophysiol. 22: 49–52.

    PubMed  Google Scholar 

  • Kamei S, Sakai T, Matsuura M, Tanaka N, Kojima T, Arakawa Y, Matsukawa Y, Mizutani T, Oga K, Ohkubo H, Matsumura H, Hirayanagi K. (2002). Eur Neurol. 48: 102–107.

    PubMed  CAS  Google Scholar 

  • Kamei S, Tanaka N, Mastuura M, Arakawa Y, Kojima T, Matsukawa Y, Takasu T, Moriyama M. (1999). Acta Neurol Scand. 100: 25–33.

    PubMed  CAS  Google Scholar 

  • Kramer L, Bauer E, Funk G, Hofer H, Jessner W, Steindl-Munda P, Wrba F, Madl C, Gangl A, Ferenci P. (2002). J Hepatol. 37: 349–354.

    PubMed  Google Scholar 

  • Kramer L, Hofer H, Bauer E, Funk G, Formann E, Steindl-Munda P, Ferenci P. (2005). AIDS. 19(Suppl 3): S85–S92.

    PubMed  Google Scholar 

  • Kraus MR, Schafer A, Csef H, Scheurlen M, Faller H. (2000). Psychosomatics. 41: 377–384.

    PubMed  CAS  Google Scholar 

  • Kraus MR, Schafer A, Wissmann S, Reimer P, Scheurlen M. (2005). Clin Pharmacol Ther. 77: 90–100.

    PubMed  CAS  Google Scholar 

  • Kronfol Z, Remick DG. (2000). Am J Psychiatry. 157: 683–694.

    PubMed  CAS  Google Scholar 

  • Kyrlagkitsis I, Portmann B, Smith H, O’Grady J, Cramp ME. (2003). Am J Gastroenterol. 98: 1588–1593.

    PubMed  Google Scholar 

  • Lang CA, Battistutta D, Garrett LE, Cooksley WGE, Dunne MP, Macdonald GA. (2003). J Gastroenterol Hepatol. 18: B85 [Abstract].

    Google Scholar 

  • Laskus T, Radkowski M, Adair DM, Wilkinson J, Scheck AC, Rakela J. (2005). AIDS. 19(Suppl 3): S140–S144.

    PubMed  Google Scholar 

  • Laskus T, Radkowski M, Bednarska A, Wilkinson J, Adair D, Nowicki M, Nikolopoulou GB, Vargas H, Rakela J. (2002). J Virol. 76: 10064–10068.

    PubMed  CAS  Google Scholar 

  • Lawson LJ, Perry VH, Gordon S. (1992). Neuroscience. 48: 405–415.

    PubMed  CAS  Google Scholar 

  • Letendre SL, Cherner M, Ellis RJ, Marquie-Beck J, Gragg B, Marcotte T, Heaton RK, McCutchan JA, Grant I. (2005). AIDS. 19(Suppl 3): S72–S78.

    PubMed  CAS  Google Scholar 

  • Lieb K, Engelbrecht MA, Gut O, Fiebich BL, Bauer J, Janssen G, Schaefer M. (2006). Eur Psychiatry. 21: 204–210.

    PubMed  Google Scholar 

  • Lim JK, Cronkite R, Goldstein MK, Cheung RC. (2006). J Clin Gastroenterol. 40: 528–534.

    PubMed  Google Scholar 

  • Macdonald GA, Garrett LE, Cook MD, Cooksley WG, Dunne MP. (2002). Proceedings of the Third Australasian Conference on Hepatitis C. Melbourne, VIC, [Abstract 50].

    Google Scholar 

  • Martin EM, Novak RM, Fendrich M, Vassileva J, Gonzalez R, Grbesic S, Nunnally G, Sworowski L. (2004). J Int Neuropsychol Soc. 10: 298–300.

    PubMed  Google Scholar 

  • McAndrews MP, Farcnik K, Carlen P, Damyanovich A, Mrkonjic M, Jones S, Heathcote EJ. (2005). Hepatology. 41: 801–808.

    PubMed  Google Scholar 

  • McDonald J, Jayasuriya J, Bindley P, Gonsalvez C, Gluseska S. (2002). J Gastroenterol Hepatol. 17: 171–176.

    PubMed  Google Scholar 

  • McHutchison JG, Ware JE Jr., Bayliss MS, Pianko S, Albrecht JK, Cort S, Yang I, Neary MP. (2001). J Hepatol. 34: 140–147.

    PubMed  CAS  Google Scholar 

  • McSweeny AJ, Grant I, Heaton RK, Prigatano GP, Adams KM. (1985). J Clin Exp Neuropsychol. 7: 281–291.

    PubMed  CAS  Google Scholar 

  • Miller ER, Hiller JE, Shaw DR. (2001). Aust N Z J Public Health. 25: 355–361.

    PubMed  CAS  Google Scholar 

  • Neary MP, Cort S, Bayliss MS, Ware JE Jr. (1999). Semin Liver Dis. 19(Suppl 1): 77–85.

    PubMed  Google Scholar 

  • Obhrai J, Hall Y, Anand BS. (2001). J Clin Gastroenterol. 32: 413–417.

    PubMed  CAS  Google Scholar 

  • Paterson DL, Gayowski T, Wannstedt CF, Wagener MM, Marino IR, Vargas H, Laskus T, Rakela J, Singh N. (2000). Clin Transplant. 14: 48–54.

    PubMed  CAS  Google Scholar 

  • Perry W, Carlson MD, Barakat F, Hilsabeck RC, Schiehser DM, Mathews C, Hassanein TI. (2005). AIDS. 19(Suppl 3): S79–S84.

    PubMed  Google Scholar 

  • Perry W, Hilsabeck RC, Hassanein TI. (2008). Dig Dis Sci. 53: 307–321.

    PubMed  Google Scholar 

  • Picton TW. (1992). J Clin Neurophysiol. 9: 456–479.

    PubMed  CAS  Google Scholar 

  • Pojoga C, Dumitrascu DL, Pascu O, Grigorescu M, Radu C, Damian D. (2004). Eur J Gastroenterol Hepatol. 16: 27–31.

    PubMed  Google Scholar 

  • Poutiainen E, Hokkanen L, Niemi ML, Farkkila M. (1994). Pharmacol Biochem Behav. 47: 901–905.

    PubMed  CAS  Google Scholar 

  • Poynard T, Cacoub P, Ratziu V, Myers RP, Dezailles MH, Mercadier A, Ghillani P, Charlotte F, Piette JC, Moussalli J. (2002). J Viral Hepat. 9: 295–303.

    PubMed  CAS  Google Scholar 

  • Radkowski M, Wilkinson J, Nowicki M, Adair D, Vargas H, Ingui C, Rakela J, Laskus T. (2002). J Virol. 76: 600–608.

    PubMed  CAS  Google Scholar 

  • Rasenack J, Zeuzem S, Feinman SV, Heathcote EJ, Manns M, Yoshida EM, Swain MG, Gane E, Diago M, Revicki DA, Lin A, Wintfeld N, Green J. (2003). Pharmacoeconomics. 21: 341–349.

    PubMed  CAS  Google Scholar 

  • Reichenberg A, Gorman JM, Dieterich DT. (2005). AIDS. 19(Suppl 3): S174–S178.

    PubMed  CAS  Google Scholar 

  • Richardson JL, Nowicki M, Danley K, Martin EM, Cohen MH, Gonzalez R, Vassileva J, Levine AM. (2005). AIDS. 19: 1659–1667.

    PubMed  Google Scholar 

  • Riedel WJ, Klaassen T, Schmitt JA. (2002). Brain Behav Immun. 16: 581–589.

    PubMed  CAS  Google Scholar 

  • Rodger AJ, Jolley D, Thompson SC, Lanigan A, Crofts N. (1999). Hepatology. 30: 1299–1301.

    PubMed  CAS  Google Scholar 

  • Rogers RD, Robbins TW. (2001). Curr Opin Neurobiol. 11: 250–257.

    PubMed  CAS  Google Scholar 

  • Rowan PJ, Al-Jurdi R, Tavakoli-Tabasi S, Kunik ME, Satrom SL, El-Serag HB. (2005). J Clin Gastroenterol. 39: 731–736.

    PubMed  Google Scholar 

  • Ryan EL, Morgello S, Isaacs K, Naseer M, Gerits P. (2004). Neurology. 62: 957–962.

    PubMed  CAS  Google Scholar 

  • Sansonno D, Iacobelli AR, Cornacchiulo V, Iodice G, Dammacco F. (1996). Clin Exp Immunol. 103: 414–421.

    PubMed  CAS  Google Scholar 

  • Schwarzinger M, Dewedar S, Rekacewicz C, Abd Elaziz KM, Fontanet A, Carrat F, Mohamed MK. (2004). Hepatology. 40: 1434–1441.

    PubMed  Google Scholar 

  • Selnes OA, McArthur JC, Royal W 3rd, Updike ML, Nance-Sproson T, Concha M, Gordon B, Solomon L, Vlahov D. (1992). Neurology. 42: 1924–1930.

    PubMed  CAS  Google Scholar 

  • Shawcross DL, Davies NA, Williams R, Jalan R. (2004). J Hepatol. 40: 247–254.

    PubMed  CAS  Google Scholar 

  • Sherman KE, Rouster SD, Chung RT, Rajicic N. (2002). Clin Infect Dis. 34: 831–837.

    PubMed  Google Scholar 

  • Shibata M, Blatteis CM. (1991). Brain Res. 562: 323–326.

    PubMed  CAS  Google Scholar 

  • Spiegel BM, Younossi ZM, Hays RD, Revicki D, Robbins S, Kanwal F. (2005). Hepatology. 41: 790–800.

    PubMed  Google Scholar 

  • Sulkowski MS, Thomas DL. (2003). Ann Intern Med. 138: 197–207.

    PubMed  Google Scholar 

  • Tarter RE, Hegedus AM, Van Thiel DH, Schade RR, Gavaler JS, Starzl TE. (1984). Gastroenterology. 86: 1421–1427.

    PubMed  CAS  Google Scholar 

  • Tassopoulos NC. (1999). J Hepatol. 31: 193–196.

    PubMed  Google Scholar 

  • Taylor MJ, Letendre SL, Schweinsburg BC, Alhassoon OM, Brown GG, Gongvatana A, Grant I. (2004). J Int Neuropsychol Soc. 10: 110–113.

    PubMed  CAS  Google Scholar 

  • Thein HH, Butler T, Krahn M, Rawlinson W, Levy MH, Kaldor JM, Dore GJ. (2006). J Urban Health. 83: 275–288.

    PubMed  Google Scholar 

  • Thein HH, Maruff P, Krahn MD, Kaldor JM, Koorey DJ, Brew BJ, Dore GJ. (2007). HIV Med. 8: 520–528.

    PubMed  CAS  Google Scholar 

  • Thomas HC, Torok ME, Forton DM, Taylor-Robinson SD. (1999). J Hepatol. 31(Suppl 1): 152–159.

    PubMed  Google Scholar 

  • von Giesen HJ, Heintges T, Abbasi-Boroudjeni N, Kucukkoylu S, Koller H, Haslinger BA, Oette M, Arendt G. (2004). J Acquir Immune Defic Syndr. 35: 131–137.

    PubMed  Google Scholar 

  • von Wagner M, Lee JH, Kronenberger B, Friedl R, Sarrazin C, Teuber G, Herrmann E, Zeuzem S. (2006). J Viral Hepat. 13: 828–834.

    PubMed  CAS  Google Scholar 

  • Ware JE Jr., Bayliss MS, Mannocchia M, Davis GL. (1999). Hepatology. 30: 550–555.

    PubMed  Google Scholar 

  • Weissenborn K, Krause J, Bokemeyer M, Hecker H, Schuler A, Ennen JC, Ahl B, Manns MP, Boker KW. (2004). J Hepatol. 41: 845–851.

    PubMed  Google Scholar 

  • Yates WR, Gleason O. (1998). Depress Anxiety. 7: 188–193.

    PubMed  CAS  Google Scholar 

  • Younossi ZM, Boparai N, McCormick M, Price LL, Guyatt G. (2001a). Am J Gastroenterol. 96: 579–583.

    PubMed  CAS  Google Scholar 

  • Younossi ZM, Boparai N, Price LL, Kiwi ML, McCormick M, Guyatt G. (2001b). Am J Gastroenterol. 96: 2199–2205.

    PubMed  CAS  Google Scholar 

  • Younossi ZM, Guyatt G, Kiwi M, Boparai N, King D. (1999). Gut. 45: 295–300.

    PubMed  CAS  Google Scholar 

  • Zdilar D, Franco-Bronson K, Buchler N, Locala JA, Younossi ZM. (2000). Hepatology. 31: 1207–1211.

    PubMed  CAS  Google Scholar 

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  1. Hla-Hla Thein
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  2. G. J. Dore
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Editors and Affiliations

  1. Dept. Nutrition and Dietetics Nutritional Sciences Research Division School of Biomedical & Health Sciences, King's College London, Franklin‐Wilkins Building 150 Stamford Street, SE1 9NH, London, UK

    Victor R. Preedy (Prof.) (Prof.)

  2. Mel and Enid Zuckerman College of Public Health, University of Arizona, Health Science Center 1295 N. Martin, P.O. Box 245155, 85724-5155, Tucson, AZ

    Ronald R. Watson (Prof.) (Prof.)

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Thein, HH., Dore, G.J. (2010). Cognitive Function, Mood and Health-Related Quality of Life in Hepatitis C Virus-Infected Individuals. In: Preedy, V.R., Watson, R.R. (eds) Handbook of Disease Burdens and Quality of Life Measures. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78665-0_191

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  • DOI: https://doi.org/10.1007/978-0-387-78665-0_191

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-78664-3

  • Online ISBN: 978-0-387-78665-0

  • eBook Packages: MedicineReference Module Medicine

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