Health-Related Quality of Life in Adults with Systemic Lupus Erythematosus

  • L-S. Teh
  • K. McElhone
  • J. Abbott
Reference work entry


 Systemic lupus erythematosus (SLE) is an uncommon autoimmune multi-system disease that tends to affect young women of child-bearing age. Nevertheless, it can have a significant impact on the  health-related quality of life (HRQOL) of patients comparable to that of more common rheumatological and medical illnesses. It is essential to measure HRQOL which captures the patients’ perspective of the impact of SLE on their lives in addition to disease activity and damage when assessing the outcomes of the patients. The most popular questionnaires for assessing HRQOL in SLE are the generic measures (Generic HRQOL measures), in particular the SF-36. However, major strides recently have seen the development and evaluation of SLE-specific measures which have the added quality that they assess issues more pertinent to patients with SLE and thus may be more sensitive to the changes in HRQOL. If this is so, SLE-specific HRQOL measures may be more useful for assessing outcomes in clinical trials of new interventions for SLE.


Systemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Damage Index Poor HRQOL Good Internal Reliability 

List of Abbreviations:


American College of Rheumatology


arthritis impact measurement scale


anti complement 1q


anti double-stranded deoxyribonucleic acid


anti ribonucleic acid


anti Sjogren’s syndrome A/B


British Isles Lupus Assessment Group


European Consensus lupus activity measure


European quality of life


health-related quality of life


lupus quality of life


quality of life


quality of life scale


short form-20


short form-36


sickness impact profile


SLE index score


systemic lupus activity measure


systemic lupus erythematosus


systemic lupus erythematosus disease activity index


systemic lupus international collaborating clinics, American college of rheumatology damage index


systemic lupus erythematosus quality of life


SLE symptom checklist


systemic lupus erythematosus quality of life


visual analogue scale


World Health Organisation quality of life – abbreviated version


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© Springer Science+Business Media LLC 2010

Authors and Affiliations

  • L-S. Teh
  • K. McElhone
  • J. Abbott

There are no affiliations available

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