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Intrauterine Growth Restriction and Later Quality of Life

  • D. Spence
Reference work entry

Abstract:

 Intrauterine growth restriction (IUGR) remains a major clinical problem in modern obstetrics. While technology has yet to aid significant prevention of IUGR, the past few decades has seen the introduction of some of the most innovative therapies in the history of  neonatal intensive care. This has resulted in an increased survival rate of a heterogeneous group of babies, including those with intrauterine growth restriction. It is therefore important to assess if the associated problems with these babies, impact on health related  quality of life long-term. Subtle psychological and social differences have been reported in childhood and early adult life and higher incidence of coronary heart disease, high blood pressure, and diabetes have also been reported in later life. However, it is unclear how this impacts on overall quality of life. Quality of life is considered an important outcome measure for healthcare interventions in adults and health status measures are key determinants of health service use. Despite the extensive cohort studies undertaken to date, there is a dearth of literature on the relationship between IUGR and quality of life, particularly in later life. A recent study addressed this gap in the literature, comparing subjects born with IUGR and a control group with normal birth weight for  gestation. Quality of life in adulthood was assessed using the Short Form-36 health survey (SF-36). The two groups reported similar quality of life on each of the eight dimensions of the SF-36 and there were no significant differences between them. Adjusting for potential confounding variables did not alter this conclusion. This chapter summarizes the impact of IUGR on later quality of life.

Keywords

Fetal Growth Fetal Alcohol Syndrome Intrauterine Growth Restriction Health Status Measure Normal Birth Weight 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:

AGA

Appropriate for gestational age

CI

Confidence intervals

CMV

Cytomegalovirus

g

Grams

GP

General Practitioner

IUGR

Intrauterine growth restriction

LMP

Last menstrual period

SD

Standard deviation

SF-36

Short Form 36 health survey

SGA

Small for gestational age

SPSS

Statistical package for social sciences

UK

United Kingdom

References

  1. Ariyuki Y, Hata T, Kitao M. (1995). Pediatrics. 96: 36–42.PubMedGoogle Scholar
  2. Bakketeig LS. (1998). Eur J Clin Nutr. 52: Suppl 1.CrossRefGoogle Scholar
  3. Barker DJP (ed.). (1992). Fetal and Infant Origins of Adult Disease. BMJ Publishing Group, London.Google Scholar
  4. Clausson B, Gardosi J, Francis A, Cnattingius S. (2001). Br J Obstet Gynaecol. 108: 830–834.CrossRefGoogle Scholar
  5. Cooke RWI. (2004). Arch Dis Child. 89: 201–206.PubMedCrossRefGoogle Scholar
  6. Crosse VM. (1949). The premature baby, 2nd ed. J & A Churchill Ltd, London.Google Scholar
  7. Drossou V, Diamanti E, Noutsia H, Konstantinidis T, Katsougiannopoulos V. (1995). Acta Paediatr. 84: 1–5.PubMedCrossRefGoogle Scholar
  8. Eiser C, Morse R. (2001). Arch Dis Child. 84: 205–211.PubMedCrossRefGoogle Scholar
  9. Ergaz M, Avgil M, Ornoy A. (2005). Reprod Toxic. 20: 301–322.CrossRefGoogle Scholar
  10. Fanaroff AA, Hack M, Kliegman RM. (1989). In: Gross TL, Sokol RJ (eds.) Intrauterine Growth Restriction a Practical Approach. Year Book Medical Publishers Inc, London.Google Scholar
  11. Garratt AM, Ruta DA, Abdalla MI, Buckingham JK, Russell IT. (1993). Br Med J. 306: 1440–1444.CrossRefGoogle Scholar
  12. Gross TL. (1989). In: Gross TL, Sokol RJ (eds.) Intrauterine Growth Restriction a Practical Approach. Year Book Medical Publishers Inc, London.Google Scholar
  13. Hack M, Taylor G, Klein N, Eiben R, Schatschneider C, Mercuri-Minich N. (1994). N Engl J Med. 331: 753–759.PubMedCrossRefGoogle Scholar
  14. Hayes V, Morris J, Wolfe C, Morgan M. (1995). Age Ageing. 24: 120–125.PubMedCrossRefGoogle Scholar
  15. Henriksen T. (1999). Acta Paediatr Suppl. 88: 4–8.PubMedCrossRefGoogle Scholar
  16. Hofman A, Jaddoe VWV, MacKenbach JP, Moll HA, Snijders RFM, Steegers EAP, Verhulst FC, Witteman JCM, Buller HA. (2004). Paediatr Perinat Epidemiol. 18: 61–72.PubMedCrossRefGoogle Scholar
  17. Hyppönen E, Power C, Davey Smith G. (2003). Diabetes Care. 26: 2515–2517.CrossRefGoogle Scholar
  18. Jenkinson C, Coulter A, Wright L. (1993). Br Med J. 306: 1437–1440.CrossRefGoogle Scholar
  19. Kilby M, Hodgett S. (2000). In: Kingdom J, Baker P (eds.) Intrauterine Growth Restriction a Practical Approach. Year Book Medical Publishers Inc, London.Google Scholar
  20. Kingdom J, Baker P (eds.). Intrauterine Growth Restriction Aetiology and Management. Springer-Verlag, London.Google Scholar
  21. Kiserud T, Maršál K. (2000). In: Kingdom J, Baker P (eds.) Intrauterine Growth Restriction a Practical Approach. Year Book Medical Publishers Inc, London.Google Scholar
  22. McCormick MC, Brooks-Gunn J, Workman-Daniels K, Turner J, Peckham GJ. (1992). JAMA. 267: 2204–2208.PubMedCrossRefGoogle Scholar
  23. Neerhof MG. (1995). Clin Perinatol. 22: 375–385.PubMedGoogle Scholar
  24. Paz I, Gale R, Laor A, Danon YL, Stevenson DK, Seidman DS. (1995). Obstet Gynecol. 85: 452–456.PubMedCrossRefGoogle Scholar
  25. Robinson JS, Owens JA, McMillen IC, Erwich JJ, Owens PC. (1997). In: Cockburn F (ed.) Advances in Perinatal Medical. The Parthenon Publishing Group, London.Google Scholar
  26. Saigal S, Rosenbaum P. (1996). Semin Neonatol. 1: 305–312.CrossRefGoogle Scholar
  27. Saigal S, Szatmari P, Rosenbaum P, King S, Campbell D. (1991). J Pediatr. 118: 751–760.PubMedCrossRefGoogle Scholar
  28. Sanders C, Egger M, Donovan J, Tallon D, Frankel S. (1998). Br Med J. 317: 1191–1194.Google Scholar
  29. Spence D, Alderdice FA, Stewart MC, Halliday HL, Bell AH. (2007). Arch Dis Child. 92: 700–703.PubMedCrossRefGoogle Scholar
  30. Strauss RS. (2000). JAMA. 283: 625–632.PubMedCrossRefGoogle Scholar
  31. Vandenbosche RC, Kirchner DO. (1998). Am Fam Physician. 15: 1384–1393.Google Scholar
  32. Ware JE, Snow KK, Kosinski M, Gandek B. (1993). The Health Institute, New England Medical Center, Boston, MA.Google Scholar
  33. Whittle MJ. (1999). In: Rodeck CH, Whittle MJ (ed.) Fetal Medicine Basic Science and Clinical Practice. Churchill Livingstone, London.Google Scholar
  34. Yanney M, Marlow N. (2004). Semin Fetal Neonatal Med. 9: 411–418.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media LLC 2010

Authors and Affiliations

  • D. Spence
    • 1
  1. 1.Nursing and Midwifery Research UnitQueen’s University BelfastBelfastUK

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