Quality of Life in Crohn’s Disease

  • S. D. Wexner
  • J. C. Frattini


 Crohn’s disease is a chronic, relapsing disease with an often early age of onset that can affect the entire gastrointestinal tract. Crohn’s disease can have a debilitating effect on a patient’s social, educational, professional, and familial activities; thus having a profound effect on their  health related quality of life (HRQOL). Only recently has an effort been made to determine the impact Crohn’s disease has on health related quality of life. Health related quality of life is a patient’s understanding of and relating to their illness within the scope of their lifestyle and in the process of doing so uses physical, psychological, cultural, educational, professional, and disease associated factors. Two types of instruments can be used to measure health related quality of life, general and disease specific, both of which look at various domains of a person’s life and must be validated,  reproducible, and reliable. The health related quality of life of Crohn’s patients has been found to be significantly worse when compared to the healthy population. It is affected by various factors like  disease activity, gender, medical and surgical treatment. It significantly affects the health related quality of life of adolescents in addition to the educational, familial, and professional aspirations of patients. Data on health related quality of life could provide valuable information on how to develop research protocols and alter treatment algorithms with the resolve of not only improving patient outcomes but also possibly improving utilization of resources.


Mucosal Healing Inflammatory Bowel Disease Questionnaire Entire Gastrointestinal Tract Professional Aspiration Decrease Disease Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:


Health related quality of life


 Inflammatory bowel disease


  1. Afzal N, Van Der Zaag-Loonen H, Arnaud-Battandier F, Davies S, Murch S, Derkx B, Heuschkel R, Fell J. (2004). Aliment Pharmacol Ther. 20: 167–172.PubMedCrossRefGoogle Scholar
  2. Andersson P, Olaison G, Bendtsen P, Myrelid P, Sjodahl R. (2003). Colorectal Dis. 5: 56–62.PubMedCrossRefGoogle Scholar
  3. Bernkley T, Jahnsen J, Schulz T, Sauar J, Lygren I, Henriksen M, Stray N, Kjellevold O, Aadland E, Vatn M, Moum B. (2005). Eur J Gastroenterol Hepatol. 17: 1037–1045.CrossRefGoogle Scholar
  4. Binder V, Hendriksen C, Kreiner S. (1985). Gut. 26: 146–150.PubMedCrossRefGoogle Scholar
  5. Blondel-Kucharski F, Chircop C, Marquis P, Cortot A, Baron F, Gendre JP, Colombel JF. (2001). Am J Gastroenterol. 96: 2915–2920.PubMedCrossRefGoogle Scholar
  6. Calvet X, Gallardo O, Coronas R, Casellas F, Montserrat A, Torrejon A, Vergara M, Campo R, Brullet E. (2006). Inflamm Bowel Dis. 12: 692–696.PubMedCrossRefGoogle Scholar
  7. Campieri M, Ferguson A, Doe W, Persson T, Nilsson LG. (1997). Gut. 41: 209–214.PubMedCrossRefGoogle Scholar
  8. Canavan C, Abrams KR, Hawthorne B, Drossman D, Mayberry JF. (2006). Aliment Pharmacol Ther. 23: 377–385.PubMedCrossRefGoogle Scholar
  9. Casellas F, Lopez-Vivancos J, Badia X, Vilaseca J, Malagelada JR. (2000). Am J Gastroenterol. 95: 177–182.PubMedCrossRefGoogle Scholar
  10. Clemett D, Markham A. (2000). Drugs. 59: 929–956.PubMedCrossRefGoogle Scholar
  11. Cohen RD. (2002). Aliment Pharmacol Ther. 16: 1603–1609.PubMedCrossRefGoogle Scholar
  12. Delaney C, Kiran R, Senagore A, O’brien-Ermlich B, Church J, Hull T, Remzi F, Fazio V. (2003). J Am Coll Surg. 196: 714–721.PubMedCrossRefGoogle Scholar
  13. Drossman D. (1993). In: Sleisenger MH, Fordtran JS (eds.) Gastrointestinal Disease: Pathophysiology, Diagnosis, and Management. WB Saunders, New York.Google Scholar
  14. Drossman DA, Patrick DL, Mitchell CM, Zagami EA, Appelbaum MI. (1989). Dig Dis Sci. 34: 1379–1386.PubMedCrossRefGoogle Scholar
  15. Drossman DA, Leserman J, Li ZM, Mitchell CM, Zagami EA, Patrick DL. (1991). Psychosom Med. 53: 701–712.PubMedGoogle Scholar
  16. Farmer RG, Easley KA, Farmer JM. (1992). Cleve Clini J Med. 59: 35–42.Google Scholar
  17. Feagan BG. (1999). Aliment Pharmacol Ther. 13(suppl. 4): 29–37.PubMedCrossRefGoogle Scholar
  18. Ferguson A, Sedgwick DM, Drummond J. (1994). Gut. 35: 665–668.PubMedCrossRefGoogle Scholar
  19. Griffiths AM, Nicholas D, Smith C, Munk M, Stephens D, Dumo C, Sherman PM. (1999). J Pediatr Gastroenterol Nutr. 28: S46–S52.PubMedCrossRefGoogle Scholar
  20. Guthrie E, Jackson J, Shaffer J, Thompson D, Tomenson B, Creed F. (2002). Am J Gastroenterol. 97: 1994–1999.PubMedCrossRefGoogle Scholar
  21. Guyatt G, Mitchell A, Irvine EJ, Singer J, Williams N, Goodacre R, Tompkins C. (1989). Gastroenterology. 96: 804–810.PubMedGoogle Scholar
  22. Hay AR, Hay JW. (1992). J Clin Gastroenterol. 14: 318–327.PubMedCrossRefGoogle Scholar
  23. Koelewijn C, Schrijvers A, Oldenburg B. (2006). Netherlands J Med. 64: 212–218.Google Scholar
  24. Lichtenstein GR, Yan S, Bala M, Hanauer S. (2004). Am J Gastroenterol. 99: 91–96.PubMedCrossRefGoogle Scholar
  25. Lopez Blanco B, Moreno-Jimenez B, Devesa Mugica JM, Rodriguez Munoz A. (2005). Rev Esp Enferm Dig. 97: 887–898.PubMedCrossRefGoogle Scholar
  26. Love JR, Irvine EJ, Fedorak RN. (1992). J Clini Gastroenterol. 14: 15–19.CrossRefGoogle Scholar
  27. Maunder RG, Cohen Z, McLeod RS, Greenberg GR. (1995). Dis. Colon Rectum. 38: 1147–1161.PubMedCrossRefGoogle Scholar
  28. Mittermaier C, Dejaco C, Waldhoer T, Oefferlbauer-Ernst A, Miehsler W, Beier M, Tillinger W, Gangi A, Moser G. (2004). Psychosom Med. 66: 79–84.PubMedCrossRefGoogle Scholar
  29. Moskovitz DN, Maunder RG, Cohen Z, McLeod RS, MacRae H. (2000). Dis Colon Rectum. 43: 517–521.PubMedCrossRefGoogle Scholar
  30. Nicholas D, Otley A, Smith C, Avolio J, Munk M, Griffiths A. (2007). Health Qual Life Outcomes. 5L: 28.CrossRefGoogle Scholar
  31. Otley A, Smith C, Nicholas D, Munk M, Avolio J, Sherman PM, Griffiths AM. (2002). J Pediatr Gastroenterol Nutr. 35: 557–563.PubMedCrossRefGoogle Scholar
  32. Otley A, Griffiths A, Hale S, Kugathasan S, Pfefferkorn M, Mezoff A, Rosh J, Tolia V, Markowitz J, Mack D, Oliva-Hemker M Wyllie R, Rothbaum R, Bousvaros A, Fernando Del Rosario J, Evans J, Blanchard W, Hyams J. (2006). Inflamm Bowel Dis. 12: 684–691.PubMedCrossRefGoogle Scholar
  33. Prantera C, Cottone M, Pallone F, Annese V, Franze A, Cerutti R, Bianchi Porro G. (1999). Gastroenterol. 116: 521–526.CrossRefGoogle Scholar
  34. Rutgeerts P, Lofberg R, Malchow H, Lamers C, Olaison G, Jewell D, Danielsson A, Goebell H, Thomsen OO, Lorenz-Meyer H. (1994). N Engl J Med. 331: 842–845.PubMedCrossRefGoogle Scholar
  35. Shorb PE. (1989). Gastroenerol Clin North Am. 18: 111–128.Google Scholar
  36. Sorensen VZ, Olsen BG, Binder V. (1987). Gut. 28: 382–385.PubMedCrossRefGoogle Scholar
  37. Thirlby R, Land J, Fenster F, Lonborg R. (1998). Arch Surg. 133: 826–832.PubMedCrossRefGoogle Scholar
  38. Thomsen OO, Cortot A, Jewell D, Wright JP, Winter T, Veloso FT, Vatn M, Persson T, Pettersson E. (1998). N Engl J Med. 339: 370–374.PubMedCrossRefGoogle Scholar
  39. Thomsen OO, Cortot A, Jewell D, Wright JP, Winter T, Veloso FT, Vatn M, Persson T, Pettersson E. (2002). Am J Gastroenterol. 97: 649–653.PubMedCrossRefGoogle Scholar
  40. Tillinger W, Mittermaier C, Lochs H, Moser G. (1999). Dig Dis Sci. 44: 932–938.PubMedCrossRefGoogle Scholar
  41. WHO. (1998). WHOQOL User Manual. Geneva: World Health Organization.Google Scholar
  42. Yazdanpanah Y, Klein O, Gambiez L, Baron P, Desreumaux P, Marquis P, Cortot A, Quandalle P, Colombel JF. (1997). Am J Gastroenterol. 92: 1897–1900.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media LLC 2010

Authors and Affiliations

  • S. D. Wexner
    • 1
  • J. C. Frattini
    • 1
  1. 1.Department of Colorectal SurgeryCleveland Clinic FloridaUSAUK

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