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Pancreatic Cancer pp 1173-1201 | Cite as

Development of Novel Pancreatic Tumor Biomarkers

  • Michael Goggins
Reference work entry

Abstract:

Pancreatic adenocarcinoma is the fourth leading cause of death due to cancer, with the lowest survival rate of any cancer. There is great interest in identifying and developing useful markers of pancreatic cancer to help detect early stage pancreatic cancer and its precursors. Markers are also needed that could predict response to emerging novel therapies for pancreatic cancer. However, the development of such markers requires well-designed studies that evaluating marker performance in the appropriate clinical settings where the marker would be required. This review discusses commonly used approaches to discover new cancer markers and how to design and evaluate studies of pancreatic cancer markers.

Keywords

Pancreatic Cancer Chronic Pancreatitis Pancreatic Adenocarcinoma Pancreatic Juice Obstructive Jaundice 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:

BEAMing

Beads, Emulsion, Amplification and Magnetics

ERCP

endoscopic retrograde cholangiopancreatography

EUS

endoscopic ultrasound

FNA

fine needle aspiration

IPMN

Intraductal papillary mucinous neoplasm

MCNs

mucinous cystic neoplasms

miRNAs

microRNAs

MSP

methylation-specific PCR

PanIN

Pancreatic intraepithelial neoplasia

RT-PCR

reverse transcriptase-polymerase chain reaction

Notes

Acknowledgment

This work was supported by the National Cancer Institute grant (CA120432, CA62924), the V foundation, the Lustgarten Foundation for Pancreatic Cancer Research and the Michael Rolfe Foundation.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Michael Goggins
    • 1
    • 2
  1. 1.Departments of Medicine, Pathology and OncologyThe Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical InstitutionsBaltimoreUSA
  2. 2.Director of the Pancreatic Cancer Early Detection LaboratoryCancer Research BuildingBaltimoreUSA

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