Skip to main content

Laparoscopic Surgery for Pancreatic Neoplasms

  • Reference work entry
Pancreatic Cancer
  • 1769 Accesses

Abstract:

Laparoscopic pancreatic resection has not been widely accepted, because it is regarded as a complicated procedure with a steep learning curve.

However, favorable postoperative results in terms of less pain, less analgesia requirement, early return of bowel function, and shorter hospital stay, in patients who underwent laparoscopic pancreatic resection (Lap PR) for left-sided benign pancreatic lesions have been consistently reported. In addition, in patients with pancreatic tumors localized in the body-tail of the pancreas laparoscopic spleen-preserving distal pancreatectomy with or without splenic vessels preservation is feasible and can be achieved in most cases. The reduced incidence of wound infection after Lap DPR is one of the recognized advantages of the laparoscopic approach. Furthermore, another clinical advantage of the Lap DPR is the reduced incidence of a late incisional hernia. Recovery is a very important outcome and can be measured by the patients’ time to return to activities of daily living. However, in oncologic surgery, while these outcomes are important, survival rates are of utmost importance. Laparoscopic en bloc splenopancreatectomy using a modified radical antegrade modular pancretosplenectomy procedure can achieve negative tangential margins in a high percent of patients with resectable malignant tumors of the body and tail of the pancreas.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 649.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Gagner M, Pomp A: Laparoscopic pylorus-preserving pancreatoduodenectomy. Surg Endosc 1994;8:408–410.

    Article  CAS  PubMed  Google Scholar 

  2. Cushieri A: Laparoscopic surgery of the pancreas. JR Coll Surg Edinb 1994;39:187–194.

    Google Scholar 

  3. Cuschieri A, Jakimowicz J: Laparoscopic pancreatic resections. Semin Laparosc Surg 1998; 5:168–179.

    CAS  PubMed  Google Scholar 

  4. Fabre JM, Dulucq JL, Vacher C, Lemoine MC, Wintringer P, Nocca D: Is laparoscopic left pancreatic resection justified? Surg Endosc 2002;19:507–510.

    Google Scholar 

  5. Patterson, EJ, Gagner, M, Salky, B, Inabnet, W.B, Brower, S, Edye, M, Gurland, B, Reiner, M, Pertsemlides, D: Laparoscopic pancreatic resection: single-institution experience with 19 patients. J Am Coll surg 2001;193:281–287.

    Article  CAS  PubMed  Google Scholar 

  6. Shimizu, S, Tanaka, M, Mizumoto, K, Yamaguchi, K: Laparoscopic pancreatic surgery: current indications and surgical results. Surg Endosc 2004;18:402–406.

    Article  CAS  PubMed  Google Scholar 

  7. Fernández-Cruz L, Sáenz A, Astudillo E, et al.: Outcome of laparoscopic pancreatic surgery: endocrine and nonendocrine tumors. World J Surg 2002;26:1057–1065.

    Article  PubMed  Google Scholar 

  8. Edwin B, Mala T, Mathisen O, Gladhayg I, Buanes T, lunde OC, Soreide O, Bergan A, Fosse E: Laparoscopic resection of the pancreas: a feasibility study of the short-term outcome. Surg Endosc 2004;18:407–411.

    Article  CAS  PubMed  Google Scholar 

  9. Velanovich V: Case-control comparison of laparoscopic versus open distal pancreatectomy. J Gastrointest Surg 2006;10:95–98.

    Article  PubMed  Google Scholar 

  10. Park AE, Heniford BT: Therapeutic laparoscopy of the pancreas. Ann Surg 2002;236:149–158.

    Article  PubMed  Google Scholar 

  11. Melotti G, Butturini G, Piccoli M, et al.: Laparoscopic distal pancreatectomy: results on a consecutive series of 58 patients. Ann Surg 2007;246(1):77–82.

    Article  PubMed  Google Scholar 

  12. Fernández-Cruz L, Cosa R, Blanco L, Levi S, López-Boado MA, Navarro S: Curative laparoscopic resection for pancreatic neoplasms: a critical analysis from a single institution. J Gastrointest Surg 2007 Dec;11(12):1607–1621.

    Article  PubMed  Google Scholar 

  13. Fernández-Cruz L, Blanco L, Cosa R, Rendón H: Is laparoscopic resection adequate in patients with neuroendocrine pancreatic tumors? World J Surg 2008 May;32(5):904–917.

    Article  PubMed  Google Scholar 

  14. Velanovich V: Case-control comparison of laparoscopic versus open distal pancreatectomy. J Gastrointest Surg 2006;10(1):95–98

    Article  PubMed  Google Scholar 

  15. Kooby D, Gillespie T, Bentrem DJ, et al.: Left-sided pancreatectomy: a multicenter comparison of laparoscopic and open approaches. Ann Surgery 2008;284:438–446.

    Google Scholar 

  16. Mabrut JY, Fernandez-Cruz L, Azagra JS, et al.: Laparoscopic pancreatic resection: results of a multicenter European study of 127 patients. Surgery 2005;137(6):597–605.

    Article  PubMed  Google Scholar 

  17. Sarr MG, Carpenter, HA, Prabhakar LP, Orchard TF, Hughes S, van Heerden JA, DiMagno EP: Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas: can one reliably differentiate benign from malignant (or premalignant) neoplasms? Ann Surg 2000;231:205–212.

    Article  CAS  PubMed  Google Scholar 

  18. Fabre JM, Houry S, Manderscheid JC, Huguier M, Baumel H: Surgery for left-sided pancreatic cancer. Br J Surg 1996;83:1065–1070.

    Article  CAS  PubMed  Google Scholar 

  19. Howard TJ, Krug JE, Yu J, Zyromski NJ, Schmidt CM, Jacobson LF, Madura JA, Wiebke EA, Lillemoe KD: A margin negative Ro resection accomplished with minimal postoperative complications. Is the surgeon’s contribution to long-term survival in pancreatic cancer. J Gastrointest Surg 2006;10:1338–1346.

    Article  PubMed  Google Scholar 

  20. Strasberg SM, Drebin JA, Linehan D: Radical antegrade modular pancreatosplenectomy. Surgery 2003;133:521–527.

    Article  PubMed  Google Scholar 

  21. Shoup M, Conlon KC, Klimstra D, Brennan MF: Is extendet resection for adenocarcinoma of the body or tail of the pancreas justified? J Gastrointest Surg 2003;7:946–952.

    Article  PubMed  Google Scholar 

  22. Christein JD, Kendrick ML, Iqbal CW, et al.: Distal pancreatectomy for resectable adenocarcinoma of the body and tail of the pancreas. J Gastrointest Surg 2005;9:922–927.

    Article  PubMed  Google Scholar 

  23. Shimada K, Sakamoto Y, Sano T, Kosuge T: Prognostic factors after distal pancreatectomy with extended lymphadenectomy for invasive pancreatic adenocarcinoma of the body and tail. Surgery 2006;139:288–295.

    Article  PubMed  Google Scholar 

  24. Lebedyev A, Zmora O, Kuriansky J, et al.: Laparoscopic distal pancreatectomy. Surg Endosc 2004; 18(10), 1427–1430.

    Article  CAS  PubMed  Google Scholar 

  25. Taylor C, O’Rourke N, Nathanson L, et al.: Laparoscopic distal pancreatectomy: the Brisbane experience of forthy-six cases. HPB 2008;10:38–42.

    Article  CAS  PubMed  Google Scholar 

  26. Laxa BU, Carbonell AM, Cobb WS, et al.: Laparoscopic and hand-assisted distal pancreatectomy. Am Surg 2008;74(6):481–487.

    PubMed  Google Scholar 

  27. Dulucq JL, Wintringer P, Mahajna A: Laparoscopic pancreaticoduodenectomy for benign and malignant diseases. Surg Endosc 2006;20(7):1045–1050.

    Article  CAS  PubMed  Google Scholar 

  28. Palanivelu C, Jani K, Senthilnathan P, Parthasarathi R, Rajapandian S, Madhankumar MV: Laparoscopic pancreaticoduodenectomy: technique and outcomes. J Am Coll Surg 2007;205(2):222–230.

    Article  PubMed  Google Scholar 

  29. Pugliese R, Scandroglio I, Sansonna F, et al.: Laparoscopic pancreaticoduodenectomy: a retrospective review of 19 cases. Surg Laparosc Endosc Percutan Tech 2008;18(1):13–18.

    Article  PubMed  Google Scholar 

  30. Eggermon AM, Steller EP, Sugarbaker PH: Laparotomy enhances intraperitoneal tumour growth and abrogates the antitumour effects of interleukin-2 and lymphokine activated killer cells. Surgery 1997;102:71–78.

    Google Scholar 

  31. Carter JJ, Feingold DL, Kirman I, et al.: Laparoscopic-assisted cecectomy is associated with decreased formation of postoperative pulmonary metastases compared with open cecectomy in a murine model. Surgery 2003;134:432–436.

    Article  PubMed  Google Scholar 

  32. Pera M, Nelson H, Rajkumar SV, et al.: Influence of postoperative acute-phase response on angiogenesis and tumor growth: open vs laparoscopic-assisted surgery in mice. J Gastrointest Surg 2003;7:783–790.

    Article  PubMed  Google Scholar 

  33. Misawa T, Shiba H, Usuba T, et al.: Systemic inflammatory response syndrome after hand-assisted laparoscopic distal pancreatectomy. Surg Endosc 2007;21(8):1446–1449.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Laureano Fernández-Cruz .

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this entry

Cite this entry

Fernández-Cruz, L. (2010). Laparoscopic Surgery for Pancreatic Neoplasms. In: Pancreatic Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77498-5_48

Download citation

Publish with us

Policies and ethics