Diagnostic and Therapeutic Response Markers

  • Anne Marie Lennon
  • Michael Goggins


Pancreatic adenocarcinoma is the fourth leading cause of death due to cancer, with the lowest survival rate of any cancer. One of the major obstacles for improving the outcome in pancreatic adenocarcinoma arises from the difficulty in diagnosing the disease at an early stage. Current methods for diagnosing pancreatic cancer are ineffective and/or impractical for identifying smaller, potentially curable lesions in the general population. Therefore the identification of tumor markers for the early detection of pancreatic cancer would be of invaluable clinical benefit. This review discusses the most important molecular markers which have been evaluated in pancreatic cancer either as diagnosis or therapeutic response markers.


Pancreatic Cancer Chronic Pancreatitis Pancreatic Adenocarcinoma KRAS Mutation Pancreatic Juice 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:


anti-epidermal growth factor receptor


Beads, Emulsion, Amplification and Magnetics.


carcinoembryonic antigen


endoscopic retrograde cholangiopancreatograph


endoscopic ultrasound


fine needle aspiration


Intraductal papillary mucinous neoplasm


mucinous cystic neoplasms


methylation-specific PCR


Pancreatic intraepithelial neoplasia


reverse transcriptase-polymerase chain reaction


serial analysis of gene expression


tissue polypeptide specific antigen


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Anne Marie Lennon
    • 1
  • Michael Goggins
    • 1
    • 2
    • 3
  1. 1.Department of MedicineThe Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical InstitutionsBaltimoreUSA
  2. 2.Department of PathologyThe Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical InstitutionsBaltimoreUSA
  3. 3.Department of OncologyThe Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical InstitutionsBaltimoreUSA

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