Principles and Applications of Microarray Gene Expression in Pancreatic Cancer

  • Malte Buchholz
  • Thomas M. Gress
Reference work entry


Like most other malignancies, pancreatic cancer is a polygenic disease arising from the accumulation of multiple genetic and epigenetic defects in the affected cells. DNA arrays offer the possibility to monitor the expression levels of thousands of mRNA transcripts simultaneously in a single assay, making them ideal tools to study the complex network of transcriptional changes that are associated with the malignant transformation of normal cells. Expression profiling analyses are rapidly expanding our knowledge of pancreatic cancer biology, laying the basis for the development of more sophisticated diagnostic procedures and more effective treatment modalities. Moreover, microarrays can directly be employed as highly sophisticated diagnostic tools in the clinic, enabling the extraction of much more detailed and differentiated diagnostic information from biopsy samples than single molecular markers or conventional diagnostic procedures can provide.


Pancreatic Cancer Class Prediction Expression Profile Analysis Mucinous Cystadenocarcinomas Clostridium Perfringens Enterotoxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Malte Buchholz
    • 1
  • Thomas M. Gress
    • 2
  1. 1.University Hospital MarburgMarburgGermany
  2. 2.Philipps-University of MarburgMarburgGermany

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