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EGFR Signaling Pathways in Pancreatic Cancer Pathogenesis

  • Caroline R. Sussman
  • Gwen Lomberk
  • Raul Urrutia
Reference work entry

Abstract:

The Epidermal Growth Factor Receptor (EGFR/ErbB) signaling axis influences the development, maintenance, and disease of tissues throughout the body. Effects have been demonstrated on normal cell proliferation, migration, differentiation, adhesion, and apoptosis in the pancreas as well as the heart, muscle, nervous system and a wide variety of organ epithelia. In addition, alterations in the EGF pathway, including overexpression of ErbBs, mutations in downstream mediators (e.g., Ras), as well as aberrant signaling, are present in the vast majority of pancreatic and other solid tissue tumors. The importance of the ErbB signaling axis to cancer is illustrated by the number of articles and reviews published on this topic to date (>20,000 and >3,000, respectively). In line with the importance of ErbB signaling to cancer, several anti-cancer therapies have been developed targeting various parts of the ErbB signaling axis. Three are currently in use, and more are undergoing intense development and investigation. Presently, the NIH lists 165 clinical studies of ErbB signaling in cancer.

Keywords

Pancreatic Cancer Pleckstrin Homology Domain Dimerization Domain ErbB Signaling Juxtamembrane Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Work in the authors’ laboratories is supported by AHA SDG 06-30137N (to CRS), NIH DK-52913 (to RU) and Mayo Clinic Pancreatic SPORE P50 CA102701 (to RU).

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Caroline R. Sussman
    • 1
    • 2
  • Gwen Lomberk
    • 2
    • 3
  • Raul Urrutia
    • 2
    • 3
  1. 1.Physiology and Biomedical EngineeringMayo ClinicRochesterUSA
  2. 2.Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Department of MedicineMayo ClinicRochesterUSA
  3. 3.Mayo Clinic Cancer Center, Mayo ClinicRochesterUSA

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