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Inflammatory Bowel Disease: Diagnosis and Evaluation

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The ASCRS Textbook of Colon and Rectal Surgery

Abstract

In 1932 Crohn, Ginzburg, and Oppenheimer1 described 13 patients with “regional ileitis” included in a total of 52 cases of nonspecific granulomatous inflammation of the intestine. Before their publication, numerous others had reported various cases of what were in retrospect, probably Crohn’s disease (CD), as early as 1813,2 but it was their published description that established the formal classification of the disease syndrome and association with noncaseating granulomas. The surgeon involved in the care of the majority of the patients, Dr. A.A. Berg, did not want his name included in the article. Because of the variable clinical and anatomic manifestations of the illness, “Crohn’s disease” has subsequently become as common a descriptor of this disease entity as the term “regional enteritis.”

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References

  1. Crohn BB, Ginzburg L, Oppenheimer GD. Regional ileitis. Jour AMA 1932;99:1323–1329.

    Google Scholar 

  2. Combe C, Saunders W. A singular case of stricture and thickening of the ileum. Med Trans R Soc Med 1806:16–18.

    Google Scholar 

  3. Brooke BN. Granulomatous diseases of the intestine. Lancet 1959;II:745–749.

    Article  Google Scholar 

  4. Lockhart‐Mummery HE, Morson BC. Crohn's disease (regional enteritis) of the large intestine and its distinction from ulcerative colitis. Gut 1960;1:87–105.

    Article  PubMed  Google Scholar 

  5. Brooke BN. The management of an ileostomy including its complications. Dis Colon Rectum 1993;36:512–516.

    Article  CAS  PubMed  Google Scholar 

  6. Truelove SC, Witts LJ, Bourne WA, et al. Cortisone and corticotropin in ulcerative colitis. Br Med J 1959:387–394.

    Google Scholar 

  7. Sutherland L, Singleton J, Sesslons J. Double blind, placebo controlled trial of metronidazole in Crohn's disease. Gut 1991;32: 1071–1075.

    Article  CAS  PubMed  Google Scholar 

  8. Korelitz BI. Immunosuppressive therapy of inflammatory bowel disease: a historical perspective. Gastroenterologist 1995;3(2): 141–152.

    CAS  PubMed  Google Scholar 

  9. Targan SR, Hanauer SB, van Deventer SJ, et al. A short‐term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 1997;337(15):1029–1035.

    Article  CAS  PubMed  Google Scholar 

  10. Dennis C. Ileostomy and colectomy in chronic ulcerative colitis. Surgery 1945;18:435–452.

    Google Scholar 

  11. Strauss AA, Strauss SF. Surgical treatment of ulcerative colitis. Surg Clin North Am 1944;24:211–224.

    Google Scholar 

  12. Kock NG. Intra‐abdominal reservoir in patients with permanent ileostomy. Arch Surg 1969;99:223–231.

    CAS  PubMed  Google Scholar 

  13. Parks AG, Nicholls RJ. Proctocolectomy without ileostomy for ulcerative colitis. Br Med J 1978;2:85–88.

    Article  CAS  PubMed  Google Scholar 

  14. Utsunomiya J. Restorative proctocolectomy for ileal reservoir. Int J Colorectal Dis 1986;1:2–19.

    Article  PubMed  Google Scholar 

  15. Ekbom A, Helmick C, Zack M, et al. The epidemiology of inflammatory bowel disease: a large, population‐based study in Sweden. Gastroenterology 1991;100:350–358.

    CAS  PubMed  Google Scholar 

  16. Yang SK, Hong WS, Min YI, et al. Incidence and prevalence of ulcerative colitis in the Songpa‐Kangdong district, Seoul, Korea. J Gastroenterol Hepatol 2000;15:1037–1042.

    Article  CAS  PubMed  Google Scholar 

  17. Sonnenberg A, McCarty DJ, Jacobsen SJ. Geographic variation of inflammatory bowel disease within the United States. Gastroenterology 1991;100:143–149.

    CAS  PubMed  Google Scholar 

  18. Loftus EV Jr, Schoenfeld P, Sandborn WJ. The epidemiology and natural history of Crohn's disease in population‐based patient cohorts from North America: a systemic review. Aliment Pharmacol Ther 2002;16:51–60.

    Article  PubMed  Google Scholar 

  19. Blanchard JF, Bernstein CN, Wajda A, et al. Small‐area variations and sociodemographic correlates for the incidence of Crohn's disease and ulcerative colitis. Am J Epidemiol 2001; 154:328–335.

    Article  CAS  PubMed  Google Scholar 

  20. Munkholm P, Langholz E, Nielsen OH, et al. Incidence and prevalence of Crohn's disease in the country of Copenhagen 1962–87: a sixfold increase in incidence. Scand J Gastroenterol 1992;27:609–614.

    Article  CAS  PubMed  Google Scholar 

  21. Hellers G. Crohn's disease in Stockholm County 1955–1974. A study of epidemiology, results of surgical treatment and long term prognosis. Scand J Gastroenterol 1979;490(suppl):580.

    Google Scholar 

  22. Gilat T, Grossman A, Fireman Z, et al. Inflammatory bowel disease in Jews. Front Gastrointest Res 1986;11:135–140.

    Google Scholar 

  23. Sonnenberg A. Occupational distribution of inflammatory bowel disease among German employees. Gut 1990;31:1037–1040.

    Article  CAS  PubMed  Google Scholar 

  24. Reif S, Klein I, Lubin F, et al. Pre‐illness dietary factors in inflammatory bowel disease. Gut 1997;40:754–760.

    Article  CAS  PubMed  Google Scholar 

  25. Boyko EJ, Perera DR, Koepsell TD, et al. Coffee and alcohol use and the risk of ulcerative colitis. Am J Gastroenterol 1989;84:530–534.

    CAS  PubMed  Google Scholar 

  26. Tanner AR, Raghunath AS. Colonic inflammation and nonsteroidal anti‐inflammatory drug administration. An assessment of the frequency of the problem. Digestion 1988;41:116–120.

    Article  CAS  PubMed  Google Scholar 

  27. Vessey M, Jewell D, Smith A, et al. Chronic inflammatory bowel disease, cigarette smoking, and use of oral contraceptives: findings in a large cohort study of women of childbearing age. Br Med J (Clin Res Ed) 1986;292:1101–1103.

    Article  CAS  Google Scholar 

  28. Calkins BM. A meta‐analysis of the role of smoking in inflammatory bowel disease. Dig Dis Sci 1989;34:1841–1854.

    Article  CAS  PubMed  Google Scholar 

  29. Ahmad T, Armuzzi A, Bunce M, et al. The molecular classification of the clinical manifestations of Crohn's disease. Gastroenterology 2002;122:854–866.

    Article  CAS  PubMed  Google Scholar 

  30. Satsangi J, Grootscholten C, Holt H, et al. Clinical patterns of familial inflammatory bowel disease. Gut 1996;38:738–741.

    Article  CAS  PubMed  Google Scholar 

  31. Bayless TM, Tokayer AZ, Polito JM II, et al. Crohn's disease: concordance for site and clinical type in affected family members—potential hereditary influences. Gastroenterology 1996;111:573–579.

    Article  CAS  PubMed  Google Scholar 

  32. Zhang WJ, Koltun WA. Genetic factors in the etiology and potential management of inflammatory bowel disease. Semin Colon Rectal Surg 2001;12(1):2–8.

    Google Scholar 

  33. Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine‐rich repeat variants with susceptibility to Crohn's disease. Nature 2001;411:559–603.

    Article  Google Scholar 

  34. Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001;411:603–606.

    Article  CAS  PubMed  Google Scholar 

  35. Gasche C, Scholmerich J, Brynskov J, et al. A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology Vienna 1998. Inflamm Bowel Dis 2000;6:8–15.

    Article  CAS  PubMed  Google Scholar 

  36. Louis E, Collard A, Oger AF, et al. Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease. Gut 2001;49:777–782.

    Article  CAS  PubMed  Google Scholar 

  37. Bernstein CN, Blanchard JF, Rawsthorne P, et al. The prevalence of extraintestinal diseases in inflammatory bowel disease: a population‐based study. Am J Gastroenterol 2001;96:1116–1122.

    Article  CAS  PubMed  Google Scholar 

  38. Generini S, Giacomelli R, Fedi R, et al. Infliximab in spondyloarthropathy associated with Crohn's disease: an open study on the efficacy of inducing and maintaining remission of musculoskeletal and gut manifestations. Ann Rheum Dis 2004;63(12):1664–1669.

    Article  CAS  PubMed  Google Scholar 

  39. Nahar IK, Shojania K, Marra CA, et al. Infliximab treatment of rheumatoid arthritis and Crohn's disease. Ann Pharmacother 2003;37(9):1256–1265.

    Article  CAS  PubMed  Google Scholar 

  40. Sheldon DG, Sawchuk LL, Kozarek RA, et al. Twenty cases of peristomal pyoderma gangrenosum: diagnostic implications and management. Arch Surg 2000;135(5):564–568.

    Article  CAS  PubMed  Google Scholar 

  41. Powell FC, Schroeter AL, Su WPD, et al. Pyoderma gangrenosum: a review of 86 patients. Q J Med 1985;217:173–186.

    Google Scholar 

  42. Poritz LS, Koltun WA. Surgical management of ulcerative colitis in the presence of primary sclerosing cholangitis. Dis Colon Rectum 2003;46(2):173–178.

    Article  PubMed  Google Scholar 

  43. Cohen S. Liver disease and gallstones in regional enteritis. Gastroenterology 1971;60:237–245.

    CAS  PubMed  Google Scholar 

  44. Talbot RW, Heppel J, Dozois RR, et al. Vascular complications of inflammatory bowel disease. Mayo Clin Proc 1986;61:140–145.

    CAS  PubMed  Google Scholar 

  45. Fichera A, Cicchiello LA, Mendelson DS, et al. Superior mesenteric vein thrombosis after colectomy for inflammatory bowel disease: a not uncommon cause of postoperative acute abdominal pain. Dis Colon Rectum 2003;46(5):643–648.

    Article  PubMed  Google Scholar 

  46. Remzi RH, Fazio VW, Oncel M, et al. Portal vein thrombi after restorative proctocolectomy. Surgery 2002;132(4):655–661.

    Article  PubMed  Google Scholar 

  47. Best WR, Becktel JM, Singleton JW, et al. Development of a Crohn's disease activity index, national cooperative Crohn's disease study. Gastroenterology 1976;70:439–444.

    CAS  PubMed  Google Scholar 

  48. Poritz LS, Koltun WA. Techniques of disease activity assessment in Crohn's disease. Semin Colon Rectal Surg 2001;12(1):16–21.

    Google Scholar 

  49. Powell‐Tuck J, Day DW, Buckell NA, et al. Correlations between defined sigmoidoscopic appearances and other measures of disease activity in ulcerative colitis. Dig Dis Sci 1982;27:533–537.

    Article  PubMed  Google Scholar 

  50. Rutegard I, Ahsgren L, Stenling R, et al. A simple index for assessment of disease activity in patients with ulcerative colitis. Hepatogastroenterology 1990;37:110–112.

    PubMed  Google Scholar 

  51. Carucci LR, Levine MS. Radiographic imaging of inflammatory bowel disease. Gastroenterol Clin North Am 2002;31(1):93–117.

    Article  PubMed  Google Scholar 

  52. Maccioni F, Viscido A, Broglia L, et al. Evaluation of Crohn's disease activity with magnetic resonance imaging. Abdom Imaging 2000;25:219–228.

    Article  CAS  PubMed  Google Scholar 

  53. Schreyer AG, Golder S, Seitz J, et al. New diagnostic avenues in inflammatory bowel diseases. Capsule endoscopy, magnetic resonance imaging and virtual enteroscopy. Dig Dis 2003;21(2): 129–137.

    Article  PubMed  Google Scholar 

  54. Koelbel G, Schmiedl U, Majer MC, et al. Diagnosis of fistulae and sinus tracts in patients with Crohn disease: value of MR imaging. AJR Am J Roentgenol 1989;152:999–1003.

    CAS  PubMed  Google Scholar 

  55. O'Donovan AN, Somers S, Farrow R, et al. MR imaging of anorectal Crohn disease: a pictorial essay. Radiographics 1997;17(1):101–107.

    PubMed  Google Scholar 

  56. Borley NR, Mortensen NJ, Jewell DP. MRI scanning in perianal Crohn's disease: an important diagnostic adjunct. Inflamm Bowel Dis 1999;5(3):231–233.

    Article  CAS  PubMed  Google Scholar 

  57. Bell SJ, Halligan S, Windsor AC, et al. Response of fistulating Crohn's disease to infliximab treatment assessed by magnetic resonance imaging. Aliment Pharmacol Ther 2003;17(3):387–393.

    Article  CAS  PubMed  Google Scholar 

  58. Van Assche G, Vanbeckevoort D, Bielen D, et al. Magnetic resonance imaging of the effects of infliximab on perianal fistulizing Crohn's disease. Am J Gastroenterol 2003;98(2):332–339.

    Article  PubMed  Google Scholar 

  59. Gasche C, Moser G, Turetschek K, et al. Transabdominal bowel sonography for detection of intestinal complication in Crohn's disease. Gut 1999;44:112–117.

    Article  CAS  PubMed  Google Scholar 

  60. Arndt JW, Grootscholten MI, van Hogezand RA, et al. Inflammatory bowel disease activity assessment using technetium‐99m‐HMPAO leukocytes. Dig Dis Sci 1997;42:387–393.

    Article  CAS  PubMed  Google Scholar 

  61. Gevers AM, Couckuyt H, CoremansG, et al. Efficacy and safety of hydrostatic balloon dilation of ileocolonic Crohn's strictures: a prospective long‐term analysis. Acta Gastroenterol Belg 1994;57:320–322.

    CAS  PubMed  Google Scholar 

  62. Iddan G, Meron G, Glukhovsky A, et al. Wireless capsule endoscopy. Nature 2000;405:417.

    Article  CAS  PubMed  Google Scholar 

  63. Fireman Z, Mahajna E, Broide E, et al. Diagnosing small bowel Crohn's disease with wireless capsule endoscopy. Gut 2003;52: 390–392.

    Article  CAS  PubMed  Google Scholar 

  64. Guindi M, Riddell RH. Indeterminate colitis. J Clin Pathol 2004;57:1233–1244.

    Article  CAS  PubMed  Google Scholar 

  65. Camilleri M, Proano M. Advances in the assessment of diseases activity in inflammatory bowel disease. Mayo Clin Proc 1989;64:800–807.

    CAS  PubMed  Google Scholar 

  66. Brignola D, Lanfarnchi GA, Campieri M, et al. Importance of laboratory parameters in the evaluation of Crohn's disease activity. J Clin Gastroenterol 1986;8:245–248.

    Article  CAS  PubMed  Google Scholar 

  67. Louis E, Belaich J, Kemseke CV, et al. Soluble interleukin‐2 receptor in Crohn's disease: assessment of disease activity and prediction of relapse. Dig Dis Sci 1995;40:1750–1756.

    Article  CAS  PubMed  Google Scholar 

  68. Cambridge G, Rampton DS, Stevens TR, et al. Anti‐neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut 1992;33:668–674.

    Article  CAS  PubMed  Google Scholar 

  69. Sandborn WJ, Landers CJ, Tremain WJ, et al. Association of antineutrophil cytoplasmic antibodies with resistance to treatment of left‐sided ulcerative colitis: results of a pilot study. Mayo Clin Proc 1996;71:431–436.

    Article  CAS  PubMed  Google Scholar 

  70. Sanborn WJ, Landers CJ, Tremain WJ, et al. Antineutrophil cytoplasmic antibody correlates with chronic pouchitis after ileal pouch anal anastomosis. Am J Gastroenterol 1995;90:740–747.

    Google Scholar 

  71. Lesage S, Zouali H, Cezard JP, et al. CARD 15/NOD2 mutational analysis and genotype‐phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet 2002;70:845–857.

    Article  CAS  PubMed  Google Scholar 

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Authors
  1. Walter A. Koltun
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Editor information

Editors and Affiliations

  1. Professor of Surgery, Mayo Clinic College of Medicine, Chairman, Division of Colon and Rectal Surgery, Mayo Clinic Foundation, Rochester, MN, USA

    Bruce G. Wolff MD, FASCRS (Senior Editors) (Senior Editors)

  2. Professor of Surgery, Chief, Section of Colorectal Surgery, Washington University School of Medicine, St. Louis, MO, USA

    James W. Fleshman MD, FASCRS (Senior Editors) (Senior Editors)

  3. Chairman, Department of Colon and Rectal Surgery, Ochsner Clinic Foundation, New Orleans, LA, USA

    David E. Beck MD, FASCRS (Senior Editors) (Senior Editors)

  4. Professor of Surgery, Mayo Clinic College of Medicine, Consultant, Colon and Rectal Surgery, Mayo Clinic and Mayo Foundation, Rochester, MN, USA

    John H. Pemberton MD, FASCRS (Senior Editors) (Senior Editors)

  5. Chief of Staff, Cleveland Clinic Florida, Weston, FL, USA

    Steven D. Wexner MD, FASCRS (Senior Editors) (Senior Editors)

  6. Victor W. Fazio Chair of Colorectal Surgery, Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA

    James M. Church BSc, MBChB, MMed Sci, FASCRS (Associate Editors) (Associate Editors)

  7. Professor of Surgery, Chief, Section of Colon and Rectal Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA

    Julio Garcia-Aguilar MD, PhD, FASCRS (Associate Editors) (Associate Editors)

  8. Department of Colon and Rectal Surgery, Lahey Clinic, Burlington, MA, USA

    Patricia L. Roberts MD, FASCRS (Associate Editors) (Associate Editors)

  9. Professor of Surgery, Head, Section of Colon and Rectal Surgery, Rush University Medical Center, Chicago, IL, USA

    Theodore J. Saclarides MD, FASCRS (Associate Editors) (Associate Editors)

  10. Division of Colon and Rectal Surgery, Department of Surgery, University of California, Irvine Medical Center, Orange, CA, USA

    Michael J. Stamos MD, FASCRS (Associate Editors) (Associate Editors)

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Koltun, W.A. (2007). Inflammatory Bowel Disease: Diagnosis and Evaluation. In: Wolff, B.G., et al. The ASCRS Textbook of Colon and Rectal Surgery. Springer, New York, NY. https://doi.org/10.1007/978-0-387-36374-5_39

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  • DOI: https://doi.org/10.1007/978-0-387-36374-5_39

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-24846-2

  • Online ISBN: 978-0-387-36374-5

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