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Handbook of Neurochemistry and Molecular Neurobiology pp 123–150Cite as

Neuro-Immune Associative Learning

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Abstract:

Neuroimmune associative learning constitutes the concomitant presentation of a neutral stimulus (conditioned stimulus, CS) and an immunomodulating agent (unconditioned stimulus, US). Representation of the CS alone is able to activate the centrally stored engram often resulting in changes in immune parameters that mimic those formed by the US (conditioned immune response). This experimental model enables to study and dissect the afferent (at association) as well as efferent (at recall) pathway of brain–immune communication. In this chapter, we will introduce this behavioral conditioning paradigm, review the available literature focusing on features of the conditioned and unconditioned stimuli, and the conditioned responses, the so far known mechanisms steering the conditioned response, and the underlying learning principles. Moreover, a theoretical framework modeling the pathways as well as the guidelines how to design neuroimmune associative learning experiments will be provided. Finally, the clinical feasibility of this behavioral approach will be discussed as a supplement to standard therapies with the aim of optimizing individual healing conditions.

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Abbreviations

CRs:

conditioned responses

CTA:

conditioned taste avoidance

SRBCs:

sheep red blood cells

6-OHDA:

6-hydroxydopamine

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Authors
  1. M.-B. Niemi
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  2. G. Pacheco-López
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  3. H. Engler
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  4. C. Riether
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  5. R. Doenlen
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  6. M. Schedlowski
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Editor information

Editors and Affiliations

  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, 10962, New York, Orangeburg, USA

    Abel Lajtha (Director) (Director)

  2. The Buniatian Institute of Biochemistry the National Academy of Sciences, 5/1 Sevag str., 375014, Yerevan, Republic of Armenia

    Armen Galoyan

  3. Dept. Immunophysiology Medical Faculty, Inst. of Normal and Pathological Physiology, Deutschhausstrase 2, D–35037, Marburg, Germany

    Hugo O. Besedovsky

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Niemi, MB., Pacheco-López, G., Engler, H., Riether, C., Doenlen, R., Schedlowski, M. (2008). Neuro-Immune Associative Learning. In: Lajtha, A., Galoyan, A., Besedovsky, H.O. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30398-7_6

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