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In Vivo Imaging of Neurotransmitter Systems with PET

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Handbook of Neurochemistry and Molecular Neurobiology

Abstract:

The advent of functional neuroimaging techniques has significantly widened the methodological repertoire of neurochemistry. Using positron emission tomography PET, the human and non-human primate brain's neurotransmitter and neuroreceptor systems can be studied in vivo. With the help of PET the distribution of the various neurotransmitter and neuroreceptor systems can be localized in precise anatomical context and several parameters of these systems can be measured in a quantitative manner. The basics of the technique, development of radiolabelled ligands, modeling and measuring radioligand effects in the brain are, among others, those key issues that are discussed concisely in the present chapter.

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Abbreviations

CT:

Computed tomography

FDG:

fluoro-deoxy-glucose

HPLC:

high performance liquid chromatography

MRI:

magnetic resonance imaging

NMSP:

N-methylspiperone

PBBS:

peripheral benzodiazepine-binding site

PET:

positron emission tomography

SA:

specific activity

SPECT:

single-photon-emission computed tomography

SR:

specific radioactivity

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Authors
  1. B. Gulyás
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  2. C. Halldin
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  3. B. Mazière
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Editor information

Editors and Affiliations

  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 10962, 140 Old Orangeburg Road, Orangeburg, New York, USA

    Abel Lajtha (Director) (Director)

  2. Institute of Experimental Medicine, Hungarian Academy of Sciences, 43, H-1083 Budapest, Szigony, Hungary

    E. Sylvester Vizi

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Gulyás, B., Halldin, C., Mazière, B. (2008). In Vivo Imaging of Neurotransmitter Systems with PET. In: Lajtha, A., Vizi, E.S. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30382-6_3

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