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IP3 Receptor and Ca2+ Signaling

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Book cover Handbook of Neurochemistry and Molecular Neurobiology

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Abstract

Calcium ions (Ca2+) are ubiquitous second messengers that play an important role in many physiological events including secretion, development, fertilization, and gene expression. However, the proper spatio-temporal regulation of the intracellular Ca2+ concentration is necessary to fulfill the function, and disturbed Ca2+ signaling is known to cause cell death and pathological disease. Inositol 1, 4, 5-trisphosphate receptor (IP3R) is a Ca2+ channel localized on the endoplasmic reticulum (ER) in the many types of cells including neurons, and is a key player to generate the proper intracellular Ca2+ dynamics for cell function. Disruption of IP3Rs leads to various physiological defects including neural development and neural plasticity. Moreover, several lines of evidence indicate that the altered IP3R activity causes supranormal Ca2+ homeostasis leading to various pathological diseases. In this review, we describe how IP3R activity is properly regulated by myriads of associated proteins, and discuss the physiological role of IP3Rs especially in neurons.

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Abbreviations

CTD:

C-terminal domain

HAP1A:

Htt-associated protein-1A

Htt:

Huntingtin

IP3R:

Inositol 1, 4, 5-trisphosphate receptor

LFS:

low-frequency stimulation

LTD:

long-term depression

LTP:

long-term potentiation

MSNs:

medium spiny neurons

NMDA:

N-methyl-d-aspartate

PTP:

permeability transient pore

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Acknowledgement

We thank Dr. Akihiro Mizutani and Dr. Yukiko Kuroda for fruitful comments on the manuscript. Supported by grants from the Ministry of Education, Science, and Culture of Japan (K. M. and Y. N.), Grant-in-Aid for Young Scientists (C. H.), and the Japan Science and Technology Agency.

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  1. C. Hisatsune
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  2. K. Mikoshiba
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Editor information

Editors and Affiliations

  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 10962, 140 Old Orangeburg Road, Orangeburg, New York, USA

    Abel Lajtha (Director) (Director)

  2. Group Director of Neuro-Developmental Disorder Research Group, RIKEN Brain Science Institute, 351-0198, 2-1 Hirosawa Wako-shi, Saitama, Japan

    Katsuhiko Mikoshiba

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© 2009 Springer Science+Business Media, LLC

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Hisatsune, C., Mikoshiba, K. (2009). IP3 Receptor and Ca2+ Signaling. In: Lajtha, A., Mikoshiba, K. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30370-3_31

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