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Encyclopedic Reference of Cancer pp 1–6Cite as

AAV

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Definition

Adeno-associated viruses (AAV) are small DNA-containing viruses that belong to the family of Parvoviridae. So far six serotypes of adeno-associated viruses (AAV-1 to AAV-6) have been isolated from humans and primates. According to current knowledge, none of these serotypes are pathogenic in humans. AAV type 2 (AAV-2) has been studied for over 30 years and is thus the best characterized AAV serotype. All AAV serotypes are currently being developed and evaluated as gene transfer vectors for the human gene therapy of various inherited or acquired diseases, including different types of cancer.

Characteristics

As with all other members of the Parvovirusfamily, AAV are non-enveloped, icosahedral capsids of about 18-24 nm in diameter. These capsids carry linear, single-stranded DNA genomes of approximately 4.6-4.8 kilobases. The genomes of all known AAV serotypes have been cloned and sequenced. With the exception of AAV-5, which is distinct from the other serotypes at both the...

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References

  1. Schlehofer, JR (1993) The tumor suppressive properties of adeno-associated viruses. Mutation Research 305:303–313

    Google Scholar 

  2. Berns KI, Giraud C (1996) Biology of adeno-associated virus. Current Topics in Microbiology and Immunology 218:1–23

    PubMed  CAS  Google Scholar 

  3. Shaughnessy E, Lu D, Chatterjee S, Wong KK (1996) Parvoviral vectors for the gene therapy of cancer. Seminars in Oncology 23:159–171

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  4. Grimm D, Kern A, Rittner K, Kleinschmidt JA (1998) Novel tools for production and purification of recombinant adeno-associated virus vectors. Human Gene Therapy 9:2745–2760

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  5. Grimm D, Kleinschmidt JA (1999) Progress in adeno-associated virus type 2 vector production: promises and prospects for clinical use. Human Gene Therapy 10:2445–2450

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Author information

Authors and Affiliations

  1. DKFZ, Heidelberg, Germany

    Dirk Grimm

Authors
  1. Dirk Grimm
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Editor information

Editors and Affiliations

  1. Division Cytogenetics - H-0400, German Cancer Research Center, Im Neuenheimer Feld, 69120, Heidelberg, Germany

    Manfred Schwab (Professor for Genetics, Director) (Professor for Genetics, Director)

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© 2001 Springer-Verlag

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Cite this entry

Grimm, D. (2001). AAV. In: Schwab, M. (eds) Encyclopedic Reference of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30683-8_2

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  • DOI: https://doi.org/10.1007/3-540-30683-8_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-66527-4

  • Online ISBN: 978-3-540-30683-2

  • eBook Packages: Springer Book Archive

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