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Endocrinology1

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Drug Discovery and Evaluation

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1 N.1 Endocrine survey

1.1 PURPOSE AND RATIONALE

The effect of steroid and peptide hormones as well as the influence of drugs on the endocrine system are detected by repeated administration of the test substances. After administration during a period of 1–4 weeks, the endocrine glands and the organs depending on hormonal influences are weighed. Furthermore, the hormonal content of the endocrine glands and blood levels of hormones determined.

1.2 PROCEDURE

Separate groups of 5–10 male and female Sprague-Dawley rats weighing 55–65 g are used. For some compounds, groups of 200 or 300 g body weight may be required. They are treated daily over a period of 6–12 days with the test compound by the intended route of orally) or by subcutaneous injections. For toxicological studies, a treatment period of 4 weeks is preferable. A similar protocol is applied in chronic toxicity studies in rats and dogs. On the day after the last application, the animals are sacrificed, weighed, and the following...

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  1. Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    Prof. Dr. Dr. H. Gerhard Vogel

  2. Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, USA

    Prof. Dr. Wolfgang H. Vogel

  3. Aventis Deutschland GmbH, Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt, Germany

    Prof. Dr. Bernward A. Schölkens & Prof. Dr. Jürgen Sandow

  4. Institut für Genetik, Avenfis Deutschland GmbH, Ludwig Maximilian-Universität München, München, Germany

    PD Dr. Günter Müller

  5. Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada

    Dr. Wolfgang F. Vogel (Assistant Professor)

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  1. Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    H. Gerhard Vogel

  2. Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, USA

    Wolfgang H. Vogel

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    Bernward A. Schölkens  & Jürgen Sandow  & 

  4. Institut für Genetik, Avenfis Deutschland GmbH, Ludwig Maximilian-Universität München, München, Germany

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    Wolfgang F. Vogel (Assistant Professor) (Assistant Professor)

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Vogel, H.G., Vogel, W.H., Schölkens, B.A., Sandow, J., Müller, G., Vogel, W.F. (2002). Endocrinology1 . In: Vogel, H.G., Vogel, W.H., Schölkens, B.A., Sandow, J., Müller, G., Vogel, W.F. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29837-1_15

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  • Print ISBN: 978-3-540-42396-6

  • Online ISBN: 978-3-540-29837-3

  • eBook Packages: Springer Book Archive

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